Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Web Developer (UI, Training Content & Adoption Tools)
$80K - $128K *
Develop engaging web-based training content and tools, ensuring accessibility and compliance. Collaborate on UI enhancements and create metrics dashboards to track user adoption for a federal data int...
1 week ago
Senior Security Engineer - Threat Detection
$157K - $238K *
Pioneer innovative threat detection engineering solutions that protect our infrastructure. Collaborate across teams to enhance our detection platform through advanced telemetry, improve pipeline relia...
Reposted 2 days ago
Senior Manager, AWS Full Stack AI Engineering
$124K - $280K *
Drive innovation by leading multidisciplinary teams in AWS Full Stack AI Engineering, shaping cloud-native solutions, and guiding strategic client conversations throughout the software development lif...
2 weeks ago
Senior Manager, AWS Full Stack AI Engineering
$124K - $280K *
Transform multidisciplinary teams by leading AWS full stack AI engineering projects, guiding technical delivery, and shaping cloud-native solutions to meet client needs across the software development...
2 weeks ago
Cloud Architect, Product Management
$164K - $246K *
Collaborate with cross-functional teams to translate cloud requirements into actionable product strategies, ensuring technical excellence and successful implementations in complex environments...
1 week ago
Senior Product Manager - Inference Platform
$228K - $285K *
Pioneer advancements in AI inference platforms, driving strategy and execution across cross-functional teams to enhance scalability and reliability for enterprise customers. Lead product initiatives f...
6 days ago
Senior Product Manager, Resident Onboarding
$120K - $145K *
Pioneer the Resident Onboarding Lift product, driving strategy and execution in partnership with AppFolio. Own the roadmap, influence product outcomes, and enhance customer experiences while collabora...
4 days ago
$120K - $150K *
Unlock potential by embedding with customers to drive technical adoption and outcomes. Leverage your enterprise experience to build, deploy, and troubleshoot solutions while fostering trust with execu...
2 weeks ago
Staff Backend Engineer - Prompt Security (Node.js / TypeScript)
$156K - $215K *
Innovate backend infrastructure for AI security, ensuring compliance and risk assessment. Collaborate in a dynamic environment, enhancing scalability and security while shaping the future of cybersecu...
3 weeks ago
Data Fusion Systems Software Engineer/Analyst (Associate, Experienced or Senior)
$94K - $200K *
Drive innovation in data fusion systems by developing advanced algorithms and collaborating with cross-functional teams to enhance tactical operations. Contribute to a dynamic environment focused on c...
Reposted 1 week ago
Data Fusion Systems Software Engineer/Analyst (Associate, Experienced or Senior)
$94K - $200K *
Drive innovation in data fusion systems by developing advanced algorithms and collaborating with cross-functional teams to enhance tactical operations. Contribute to cutting-edge software solutions th...
2 weeks ago
$240K - $330K *
Champion strategic initiatives and drive execution as a trusted advisor to the CEO and Executive Leadership Team, ensuring alignment and informed decision-making across the organization while navigati...
Yesterday
Forward Deployed Engineer - AI, Dedicated Staffing
$120K - $145K *
Play a key role in designing and deploying AI solutions for a healthcare client, collaborating with engineering and business teams to enhance operational capabilities and ensure successful implementat...
Yesterday
$80K - $95K *
Optimize energy solutions by leading technical projects, conducting site surveys, and collaborating with teams to deliver innovative, cost-effective strategies that enhance facility performance and su...
1 week ago
$110K - $130K *
Transform the security landscape by integrating security practices into CI/CD pipelines and Kubernetes environments, ensuring robust protection for cloud-native applications, AI services, and infrastr...
Reposted 1 week ago
$135K - $175K *
Shape the future of ad experiences by designing engaging offerwall units, balancing player, publisher, and advertiser needs. Collaborate with cross-functional teams to optimize formats, enhance perfor...
4 days ago
Site Reliability Engineer (SRE)
$110K - $130K *
Unlock potential by joining a dynamic Global SRE team focused on enhancing software reliability and observability. Collaborate with teams to implement best practices and innovative solutions, ensuring...
4 days ago
Senior Cybersecurity Engineer (Center of Excellence)
$131K - $219K *
Join a team that's redefining cybersecurity in the energy sector. You'll lead complex projects, develop standards, and automate processes to enhance efficiency and security across global Grid Automati...
1 week ago
Staff Backend Engineer, User Safety
$217K - $303K *
Empower your career by leading innovative solutions in a dynamic environment. Collaborate with cross-functional teams to enhance automated detection and enforcement strategies, driving impactful chang...
1 week ago
$150K - $170K *
Drive innovation as you lead AI-powered product design initiatives, collaborating with teams to create transformative user experiences. Shape the future of technology by designing functional, user-cen...
1 week ago
Director, Product Management - Infrastructure Automation
$200K - $220K *
Lead product management for an innovative infrastructure automation platform, driving strategy and vision while managing a team of senior product managers. Collaborate cross-functionally to enhance cu...
6 days ago
$125K - $150K *
Transform enterprise data architecture through expert Azure platform engineering, enhancing reliability, governance, and cost-efficiency while collaborating with cross-functional teams to optimize dat...
Reposted 6 days ago
Program Manager, Onsite Data Collection
$110K - $130K *
Explore the dynamic role of a Program Manager, overseeing end-to-end data collection programs. Drive operational excellence, client satisfaction, and strategic execution in a fast-paced environment, e...
1 week ago
Process Engineer - Life Sciences
$110K - $130K *
Join a dynamic team to define and design life sciences manufacturing processes, ensuring compliance and efficiency in facility layouts. Collaborate with multidisciplinary teams to translate complex re...
1 week ago
$150K - $180K *
Shape the future of product management by leading complex engagements, defining vision, and ensuring seamless collaboration across teams to deliver exceptional results and drive product success...
4 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.