Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$164K - $222K *
Lead the charge in crafting advanced game engine systems, ensuring optimal performance and player experience while collaborating with diverse teams to enhance gameplay and develop innovative solutions...
Reposted 2 weeks ago
Senior Developer Marketing Manager, Lifecycle & Growth
$133K - $186K *
Optimize developer engagement by managing the user journey from first touch to activation. Collaborate with teams to enhance the Developer Hub and drive measurable growth through effective lifecycle m...
1 week ago
Senior Product Manager, AI Evaluation & Quality| Level 18| US: Remote
$150K - $159K *
Analyze and build evaluation frameworks for AI agents, ensuring quality and performance meet client and business standards. Collaborate with cross-functional teams to establish testing methodologies a...
6 days ago
Senior Product Designer, Developer Foundations
$180K - $212K *
Lead the design of a comprehensive Developer Portal, enhancing the developer experience through intuitive interfaces and impactful improvements. Collaborate with cross-functional teams to drive user-c...
2 weeks ago
Senior Partner Manager, Data & AI Security
$175K - $326K *
Grow your career with a strategic role driving Data & AI Security channel sales. Collaborate with partners to develop scalable practices, enhance revenue, and shape go-to-market strategies while engag...
1 week ago
Senior Business Systems Analyst
$107K - $180K *
Lead the resolution of complex integration issues, collaborating with cross-functional teams to enhance reliability and support. Develop documentation and tools that empower partners and improve opera...
2 weeks ago
Senior Director, Software Engineering
$290K - $436K *
Elevate our mobile engineering organization by leading teams, driving modernization, and ensuring app performance and quality. Collaborate with cross-functional partners to innovate and mentor future...
4 days ago
Senior Developer- Python Full Stack
$120K - $145K *
Drive the design and implementation of innovative pricing tools, enhancing market readiness and efficiency. Collaborate across teams to establish technical standards and mentor junior developers while...
1 week ago
Principal Applied Scientist (User Modeling)
$195K - $312K *
Advance user modeling by driving complex AI projects end-to-end, collaborating with cross-functional teams to translate cutting-edge research into impactful solutions for home shopping experiences...
2 weeks ago
$165K - $215K *
Champion the evolution of Android features, driving product impact through collaboration and innovation. Own the development process from concept to deployment, ensuring high-quality user experiences...
1 week ago
Senior Data Scientist I, Growth & Engagement
$159K - $188K *
Unlock potential by leveraging data to drive product decisions and enhance user engagement. Collaborate across teams to design experiments, develop predictive models, and influence product strategies...
1 week ago
$110K - $130K *
Champion seamless technical integrations by leading end-to-end delivery, troubleshooting, and documentation. Collaborate with customer IT teams to ensure compliance and optimize data flows in a dynami...
4 weeks ago
$122K - $183K *
Transform the aerospace certification landscape by leading process development, ensuring compliance with DO-178C standards, and collaborating with cross-functional teams to deliver high-quality softwa...
1 week ago
Senior Practice Engagement Manager
$135K - $160K *
Unlock your potential as a key player in driving Sourcing and Procurement transformation. Collaborate with diverse teams to enhance client relationships, lead proposals, and deliver innovative solutio...
Reposted 1 week ago
Senior Workforce Experience Consulting Manager
$150K - $180K *
Transform your career by leading strategic workforce enablement initiatives. As a Senior Manager, you'll collaborate with senior executives, shape learning strategies, and drive impactful change acros...
1 week ago
Automation Test Engineer - 6568322
$128K - $149K *
Unlock potential by leading test automation initiatives, developing scalable frameworks, and implementing CI/CD processes. Collaborate in Agile environments to enhance quality across web, API, and mai...
Yesterday
$192K - $240K *
Empower innovation as you lead complex AI system design and delivery, influencing architecture and engineering practices. Collaborate across teams to ensure scalable, high-quality solutions with signi...
Reposted 2 weeks ago
Senior Detection Engineer, Protective Services
$159K - $235K *
Champion advanced detection engineering to enhance threat identification capabilities. Collaborate with Protective Services to develop and optimize detection systems, integrating diverse data sources...
4 weeks ago
$95K - $105K *
Join a dynamic team to provision and manage cloud environments, automate deployments, and ensure robust cloud security. Leverage your expertise in AWS or Azure and OpenShift to drive cloud migrations...
5 days ago
$95K - $105K *
Drive cloud infrastructure excellence by managing environments, automating deployments, and ensuring security. Collaborate on cloud migrations and capacity planning while producing essential documenta...
1 week ago
Strategic Account Executive - Chicago
$114K - $172K *
Drive strategic growth by leading enterprise accounts in Chicago, guiding influential organizations through complex digital transformations with GitLab's AI-powered DevSecOps platform, and building lo...
Reposted today
Senior Solution Consultant, Cloud Platform and AI
$120K - $145K *
Transform customer experiences by delivering expert guidance on Atlassian Cloud and AI solutions. Collaborate with clients to solve complex challenges, drive value realization, and expand service oppo...
4 weeks ago
Manager II, Engineering - Kubernetes Platform
$177K - $364K *
Empower a team of engineers to enhance Kubernetes platform infrastructure, driving reliability, security, and efficiency while collaborating across departments to achieve strategic goals and operation...
1 week ago
Senior Deep Learning Software Engineer, Inference and Model Optimization
$184K - $356K *
Transform the future of AI by optimizing generative models for efficiency. Collaborate with cross-functional teams to enhance automated deployment solutions, leveraging cutting-edge technologies in de...
3 weeks ago
Principal Product Security Engineer
$229K - $258K *
Lead the charge in shaping product security strategy, driving cross-functional initiatives, and embedding security by design into engineering workflows. Collaborate with teams to enhance vulnerability...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.