Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Product Security Engineer
$120K - $150K *
Contribute to securing products throughout their lifecycle by collaborating with developers, leading design reviews, and performing penetration testing to enhance security measures and compliance post...
1 week ago
$150K - $180K *
Lead the charge in delivering advanced AI-powered solutions using Python. Collaborate with cross-functional teams to tackle complex challenges and drive innovation in Generative AI across diverse proj...
Reposted today
Senior Data Scientist I, Monetization
$159K - $188K *
Transform audience and measurement products by independently owning the full lifecycle, from problem framing to delivery. Collaborate with cross-functional teams to enhance data-driven advertising sol...
Reposted today
$120K - $145K *
Shape the future of digital transformation by leading a dynamic team to deliver innovative solutions that enhance business efficiency and customer experience across multi-functional AWS programs...
1 week ago
$120K - $145K *
Unlock AI-driven engineering transformation by collaborating with clients to enhance SDLC processes. Drive measurable improvements in delivery speed and quality through innovative solutions and hands...
2 weeks ago
Senior Information Technology Manager - ServiceNow Platform Leader
$177K - $277K *
Champion the ServiceNow platform by leading enterprise product management, driving modernization, and fostering strategic relationships to enhance operational stability and performance across global t...
Yesterday
$207K - $250K *
Unlock your potential as you lead engineering teams in building innovative platforms and AI experiences. Collaborate across departments to drive technical direction and elevate team performance while...
5 days ago
Senior DevOps Engineer - SRC Logistics, Inc.
$110K - $130K *
Drive the reliability and security of enterprise SaaS platforms by managing Linux environments, automating processes, and collaborating with engineering teams to enhance operational efficiency and cus...
Today
Lead Engineer - Mechanical @ NDBS
$100K - $120K *
Lead the charge in mechanical design for mission-critical facilities, transforming owner requirements into reliable HVAC and piping systems. Collaborate with multidisciplinary teams to ensure timely...
2 weeks ago
Staff Technical Program Manager, Enterprise Transformation
$120K - $145K *
Shape complex, cross-functional programs that drive enterprise transformation, focusing on Customer Data Platform implementation and AI initiatives. Collaborate with diverse teams to ensure strategic...
1 week ago
Senior Group Product Manager, Marketing Platform
$187K - $260K *
Lead the charge in shaping our marketing technology ecosystem, driving product strategy and team development while enhancing workflows and cross-channel capabilities for data-driven marketing success...
1 week ago
$128K - $160K *
Lead the charge in delivering innovative AI and automation solutions, translating complex business needs into technical designs. Collaborate across teams to enhance productivity and drive continuous i...
1 week ago
DevOps Technical Lead / Architect - Azure & Terraform
$135K - $160K *
Innovate with us to modernize a .NET insurance platform, leading a DevOps team to enhance CI/CD practices, automate infrastructure, and drive scalable architecture for improved stability and performan...
Today
Principal / Lead Product Manager, Carrier Connectivity
$135K - $210K *
Lead the charge in solving complex carrier connectivity challenges in commercial insurance. Collaborate with cross-functional teams to streamline workflows and enhance product delivery, ensuring seaml...
Yesterday
Principal Product Manager, GRC
$150K - $180K *
Drive product strategy and execution for a critical portfolio area, leading cross-functional teams to transform user insights into impactful software solutions while mentoring others and shaping platf...
1 week ago
Principal Technical Program Manager, Data Centers
$102K - $209K *
Transform data center operations by leading end-to-end capacity delivery programs. Collaborate with diverse teams to ensure timely project execution, quality assurance, and stakeholder engagement, dri...
2 weeks ago
Technical Product Manager (Integrated Solutions)
$180K - $220K *
Lead the integration of complex defense solutions by translating tactical requirements into innovative products. Collaborate with cross-functional teams to optimize performance and drive market adopti...
2 weeks ago
Senior Engineering Manager, AI Platform
$150K - $180K *
Lead and develop a high-performing Applied AI team, driving the delivery of production AI systems while ensuring security, reliability, and operational excellence in healthcare applications...
Today
Senior Manufacturing & Automation Engineer
$100K - $120K *
Lead and develop a dynamic engineering team to enhance manufacturing processes, establish standards, and drive cross-functional collaboration, ensuring alignment with business objectives in high-preci...
3 weeks ago
Principal Engineer, System Performance Analytics
$200K - $275K *
Lead the development of off-board AI evaluation frameworks to optimize safety and performance for autonomous vehicles. Collaborate with cross-functional teams to design scalable systems and enhance di...
Reposted 1 week ago
Backend Engineer, Developer & End-user Experience Platform
$130K - $160K *
Drive the evolution of Stripe's authentication stack as a Backend Engineer, enhancing security and scalability while collaborating with teams to deliver innovative IAM solutions supporting enterprise...
Reposted 3 weeks ago
$85K - $97K *
Accelerate progress at our team by developing and deploying full-stack solutions. Collaborate on REST APIs, enhance legacy applications, and ensure secure coding practices while delivering high-qualit...
6 days ago
Senior Project Manager (City and County)
$130K - $154K *
Lead complex projects to enhance organizational efficiency, manage timelines, and coordinate cross-functional teams. Drive strategic goals while ensuring compliance and fostering strong stakeholder re...
3 weeks ago
Senior Developer (MES/Ignition)
$110K - $130K *
Accelerate the development of Manufacturing Execution Systems (MES) by collaborating with clients to solve complex manufacturing challenges through innovative automation and programming solutions, whi...
2 weeks ago
$135K - $160K *
Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.