Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$148K - $215K *

Unlock your potential by leading the design and optimization of enterprise load balancing solutions. Collaborate with cross-functional teams to enhance application delivery and ensure high availabilit...

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$150K - $200K *

Manage advanced product development programs for data center infrastructure, collaborating with cross-functional teams to drive comprehensive manufacturing strategies, optimize operations, and ensure...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$119K - $140K *

Shape the future of technology in healthcare by leading development efforts, leveraging AI tools, and ensuring high-quality digital deliverables across multiple platforms. Collaborate with creative te...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $151K *

Advance your career by leading financial reporting and forecasting efforts. Collaborate across departments to analyze data, streamline processes, and support strategic planning in a dynamic, high-grow...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Transform quality management practices by driving supplier improvement initiatives and ensuring compliance. Leverage your analytical skills to resolve quality issues and foster collaboration across te...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$84K - $187K *

Join the AI Automation team to innovate and implement AI solutions that enhance efficiency and security. Collaborate with experts to build automations, connect systems, and experiment with cutting-edg...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$132K - $176K *

Shape the future of cybersecurity by leading big data solutions to identify and disrupt malicious threats. Collaborate with cross-functional teams, innovate with cutting-edge technologies, and drive t...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$135K - $159K *

Optimize client partnerships by driving strategic outreach and proposals. Leverage AI tools to enhance sales cycles, mentor peers, and contribute to revenue growth through long-term relationships and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$240K - $330K *

Unlock potential by leading a global enablement team to develop and implement a comprehensive strategy that enhances sales effectiveness and drives revenue growth across all customer-facing roles...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $115K *

Innovate testing strategies and enhance software quality through automated and manual verification. Collaborate across teams to ensure compliance and optimize processes while leveraging AWS and full-s...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Elevate customer experiences by driving the integrations roadmap, enhancing capabilities, and collaborating across teams to deliver impactful solutions that meet compliance needs and improve product o...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that develops innovative HVAC&R solutions for commercial and defense sectors. Drive product design, support legacy systems, manage projects, and ensure compliance in engineering practices...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $145K *

Architect and enhance scalable infrastructure and CI/CD pipelines, collaborating across engineering teams to implement innovative cloud technologies and open-source solutions for optimal product deliv...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$217K - $303K *

Lead the charge in redefining moderation on a global scale, transforming community enforcement through innovative AI/ML solutions. Shape user experiences and drive impactful product strategies to supp...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$183K - $216K *

Take ownership of the scientific and product roadmap for monetization, leading audience creation and measurement methodologies. Collaborate with cross-functional teams to drive product strategy and in...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $95K *

Engineer automated systems to enhance production efficiency and quality. Lead projects from design to implementation, optimizing processes through data analysis and collaboration with cross-functional...

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$360K - $495K *

Lead the charge in product management, driving strategy and execution across multiple product pillars. Build a high-performing team, establish operational excellence, and ensure customer-centric outco...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $180K *

Champion the security strategy for a cutting-edge platform, focusing on supply chain security, code scanning, and threat modeling. Collaborate with teams to enhance security practices and drive innova...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $135K *

Analyze supplier capabilities and integrate quality into engineering processes. Contribute to continuous improvement initiatives, ensuring compliance with specifications and regulations while fosterin...

Reposted yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $135K *

Drive supplier quality assurance by integrating engineering processes, assessing capabilities, and mitigating risks. Collaborate cross-functionally to enhance supplier performance and ensure complianc...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Transform application deployment by collaborating with teams to streamline processes, enhance automation, and ensure high-quality releases across environments while mentoring junior members and drivin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$84K - $87K *

Join us as a Data Operations Engineer, where you'll develop and manage data systems for healthcare claims processing. Collaborate with teams to ensure data accuracy and optimize ETL/ELT pipelines whil...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Grow your career with a dynamic frontend engineering team focused on building robust platforms. Collaborate across teams to enhance product features, ensure high-quality deliverables, and drive innova...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$89K - $139K *

Drive the transformation of employee experiences by leading a multi-year Digital Employee Experience (DEX) program. Oversee analytics, enhance productivity, and implement AI-driven solutions to optimi...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$132K - $165K *

Accelerate progress at multi-site data center and AI programs valued over $25M. Lead diverse teams to ensure successful delivery, budget management, and customer satisfaction while driving executive c...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.