Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$195K - $225K *
Drive security innovation by shaping technical strategies and frameworks that protect sensitive data and systems. Collaborate across teams to embed security practices, mentor engineers, and ensure com...
1 week ago
$130K - $160K *
Drive the development of autonomous AI systems that enhance decision-making across platforms. Shape AI architecture, integrate tools, and lead the creation of impactful AI solutions from concept to pr...
3 weeks ago
Staff Solutions Engineer, MSSP Partner
$224K - $308K *
Transform the MSSP partner landscape by driving adoption, building relationships, and integrating cutting-edge solutions. Collaborate with partners to enhance technical offerings and ensure success ac...
2 weeks ago
Data Engineering Manager - AI & Data Modernization
$94K - $293K *
Transform data engineering practices by leading modernization efforts, focusing on batch and streaming pipelines, AI-ready data, and governance frameworks to ensure trust and quality in data consumpti...
1 week ago
Security Engineer, Nation State
$150K - $180K *
Shape the future of security by leading cross-functional initiatives to enhance incident detection and response capabilities. Collaborate with diverse teams to identify risks, develop automation, and...
4 weeks ago
Director, Software Engineering
$150K - $180K *
Lead and inspire a blended team of developers to enhance AI-driven legal automation platforms, ensuring technical excellence, delivery, and collaboration across functions while managing architecture...
4 weeks ago
Principal Cloud Security Engineer
$159K - $210K *
Unlock potential by leading cloud security architecture and posture management across multi-subscription environments. Drive automation, establish guardrails, and collaborate with teams to ensure secu...
Yesterday
Lead Product Manager, Engagement
$179K - $220K *
Empower HR leaders by shaping the future of employee listening. Lead product strategy from discovery to launch, creating impactful solutions that enhance engagement and drive actionable insights for o...
Reposted 1 week ago
Frontend Engineer, Underwriting
$115K - $168K *
Engineer innovative web interfaces as part of a dynamic team, enhancing underwriting workflows. Collaborate across disciplines to deliver a user-centric platform that scales, integrating AI for effici...
Reposted 3 days ago
Lead DevOps Engineer St. Louis, USA
$112K - $135K *
Transform the future of cloud solutions by leading DevOps initiatives, enhancing automation, and collaborating across teams to streamline application onboarding and deployment processes in a dynamic...
Today
Senior Solutions Architect Operations Manager
$115K - $194K *
Empower our Solutions Architects by enhancing operational tools and workflows. Drive efficiency and effectiveness in customer engagement processes, ensuring data quality and reporting standards are me...
Reposted today
$153K - $166K *
Elevate your career as a Senior Engineer, driving governance and compliance in identity management. Collaborate across teams to enhance security and user experience while managing access for human and...
Today
$110K - $130K *
Drive your career forward by enhancing security systems that protect our workforce and cloud services. Own identity controls, endpoint security, and incident response while building automation for sca...
6 days ago
$120K - $150K *
Empower a cross-functional team by owning the end-to-end design experience for a key product area, enhancing communication for families and educators while mentoring fellow designers and leveraging AI...
1 week ago
Staff Backend Engineer - Mimir Query, Databases | USA | Remote
$174K - $209K *
Lead the charge in optimizing distributed systems, ensuring performance and reliability for Mimir, a key telemetry database. Collaborate with a remote team to design, maintain, and enhance scalable so...
Reposted 2 weeks ago
$137K - $231K *
Empower your career by shaping design systems that enhance user experience. Collaborate with teams to build high-quality, interactive UI across platforms, ensuring accessibility and performance while...
2 weeks ago
Application Engineer - Seattle, WA
$95K - $120K *
Unlock potential by serving as a technical partner to sales, providing expertise in automation solutions. Manage application opportunities, engage with customers, and recommend improvements to align t...
1 week ago
REMOTE - Principal Platform Software Engineer- Oracle Health
$105K - $234K *
Lead the design and delivery of complex platform capabilities, enhancing reliability and security while mentoring engineers. Collaborate across teams to drive technical excellence and implement AI-ass...
1 week ago
$125K - $150K *
Deliver innovative engineering solutions across a luxury property portfolio, ensuring optimal maintenance, compliance, and operational excellence. Lead teams, manage vendor relationships, and drive ca...
3 weeks ago
$150K - $200K *
Develop and maintain robust data pipelines and models, collaborating with cross-functional teams to enhance data practices and ensure quality. Drive modernization efforts in data engineering, optimizi...
1 week ago
Senior Solutions Engineer, Acquisition | West Coast | Remote
$204K - $254K *
Drive customer success by leveraging technical expertise to engage, educate, and empower clients. Collaborate with sales to articulate value propositions and enhance product offerings in a dynamic, re...
6 days ago
$130K - $155K *
Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...
5 days ago
Senior Product Development Leader
$110K - $130K *
Unlock potential by leading commercialization and scale-up of innovative food products. Utilize your expertise in meat science and hands-on leadership to transform product designs into reliable manufa...
2 weeks ago
$115K - $154K *
Elevate your career with a dynamic role in full-stack Java development, focusing on scalable applications and cloud solutions. Collaborate in an Agile environment to drive innovation and modernization...
2 days ago
$181K - $226K *
Join our dynamic team as a Software Engineer, where you'll enhance internal tools, collaborate with stakeholders, and drive improvements in cloud infrastructure and observability, all while working in...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.