Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Forward Deployed Engineer (TypeScript + AI) - Remote - USA
$120K - $145K *
Accelerate progress at the intersection of engineering and AI, embedding with enterprise teams to architect and deliver robust AI solutions that meet real-world demands in regulated industries...
1 week ago
Manufacturing Quality Engineer, Data Center Equipment
$110K - $130K *
Transform the quality landscape of data center equipment by overseeing supplier audits, inspections, and continuous improvement initiatives. Collaborate with cross-functional teams to ensure complianc...
3 days ago
$95K - $115K *
Empower innovation as you design complex electrical systems, lead projects, mentor teams, and ensure high-quality deliverables. Collaborate closely with multi-disciplinary teams, utilizing advanced BI...
Reposted 3 weeks ago
$95K - $115K *
Oversee complex electrical design projects and deliver fully constructible BIM models. Collaborate with cross-functional teams, mentor peers, and ensure compliance with safety standards while developi...
Reposted 3 weeks ago
Senior Front-End Engineer (Angular)
$120K - $145K *
Join a team that's shaping the future of consumer payments by designing and building scalable Angular applications. Collaborate across disciplines to create intuitive user experiences while maintainin...
Today
Product Engineer II - Web Services
$79K - $133K *
Elevate progress at the forefront of ArcGIS Hub by transforming customer workflows, communicating priorities, and enhancing geospatial collaboration through innovative product management...
Reposted today
Solution Architect, Forward Deployed AI
$135K - $160K *
Transform AI pilots into secure, reliable production systems by designing innovative solutions and collaborating with cross-functional teams to ensure responsible enterprise adoption of AI technologie...
Today
Director, Business Operations - Products & Platforms
$160K - $195K *
Drive operational excellence and lead a high-performing team to deliver complex digital products. Collaborate with cross-functional teams to define strategies, manage resources, and ensure profitable...
2 weeks ago
$156K - $260K *
Empower cyber defense initiatives by designing, implementing, and optimizing advanced security solutions. Lead investigations, mentor teams, and enhance detection capabilities to proactively mitigate...
3 weeks ago
Senior Project Manager, Implementation
$112K - $126K *
Join a team that's driving impactful healthcare solutions by managing complex projects from initiation to stabilization. Collaborate with cross-functional teams to ensure timely delivery and high-qual...
Reposted today
Staff Security Software Engineer
$160K - $246K *
Champion innovative IAM solutions by designing secure software and optimizing SaaS services. Collaborate across teams to embed security practices, conduct threat modeling, and enhance monitoring syste...
5 days ago
Client Security & Protocols Engineering Manager
$500K+*
Elevate security by leading a dynamic team to protect client applications across diverse platforms. Drive strategy and technical direction for foundational security capabilities, ensuring robust defen...
Yesterday
$77K - $124K *
Join a team that's dedicated to developing robust software for industrial equipment. You'll leverage C#/.NET skills to create and support Windows applications, collaborating with cross-functional team...
3 weeks ago
Director, Features System Engineering
$220K - $290K *
Accelerate the development of autonomous systems by leading systems engineering strategies, aligning cross-functional teams, and ensuring rigorous safety and performance standards throughout the produ...
2 weeks ago
Director, Onboard Core Software
$240K - $330K *
Champion the development of onboard software for autonomous vehicles, leading cross-functional teams to ensure a robust software foundation. Drive strategic vision, quality, and operational excellence...
3 weeks ago
$140K - $150K *
Join a team that's driving strategic project execution and mentoring talent. Leverage advanced data analytics to build impactful dashboards and navigate stakeholder relationships, ensuring alignment w...
3 weeks ago
Director of People Programs, Systems & Analytics
$152K - $210K *
Transform workforce data into actionable insights by leading People programs, systems, and analytics. Drive strategic initiatives, enhance operational efficiency, and foster a culture of continuous im...
2 weeks ago
$110K - $130K *
Optimize program delivery by leading complex projects from proposal to execution. Drive cross-functional collaboration, manage budgets, and ensure customer commitments are met while mentoring junior p...
2 weeks ago
Senior Manager, Deployed Engineering
$150K - $180K *
Pioneer innovative solutions as a Senior Manager in Deployed Engineering, leading hands-on deployments and building a high-performing team. Collaborate closely with customers and internal teams to dri...
3 weeks ago
Senior Systems Engineer (Remote)
$110K - $130K *
Drive innovation by leading the design and implementation of complex systems, ensuring reliability and scalability while aligning engineering solutions with business objectives in federal IT moderniza...
2 weeks ago
$250K - $500K+*
Drive innovation by collaborating with hardware teams to enhance tools, evolve compilers, and improve developer experiences, ensuring efficient and effective hardware design processes...
1 week ago
$125K - $150K *
Join a team that's shaping the future of cloud infrastructure by managing a vast AWS estate. Drive automation, maintain platform health, and deliver new features while ensuring compliance in a regulat...
2 weeks ago
Senior Software Architect, AI Systems and Networking
$224K - $431K *
Join a team that's redefining AI networking by driving innovation in performance and scalability of distributed systems, optimizing data processing for large language models and generative AI workload...
Reposted 4 days ago
Senior AI Data & Analytics Engineer II
$137K - $231K *
Accelerate your career by architecting data solutions that drive AI and analytics at scale. Collaborate with cross-functional teams to transform complex business challenges into impactful data product...
2 weeks ago
Principal Solutions Engineer, Strategic (East & Central)
$193K - $252K *
Join a team that's passionate about solving complex business challenges. As a Principal Solutions Engineer, you'll engage with enterprise clients, drive strategic relationships, and showcase the value...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.