Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$85K - $130K *

Champion innovative control systems for industrial solutions, leading design and development projects. Collaborate with teams to ensure products meet market demands while transitioning designs to manu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$177K - $290K *

Transform UX operations by unifying decision-making and enhancing workflows across disciplines. Drive continuous improvement through automation and strategic partnerships, ensuring a cohesive UX organ...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Consumer Technology

$104K - $166K *

Accelerate automation initiatives by developing end-to-end solutions using Ansible, Python, and RESTful APIs. Collaborate with cross-functional teams to enhance operational efficiency and ensure compl...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$95K - $115K *

Empower your career by bridging sales and engineering as a key technical resource. You'll scope, quote, and support customer needs for low and medium-voltage switchgear solutions, ensuring alignment w...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $170K *

Advance your career by leading a dynamic team in developing secure access solutions. Drive technical direction, manage project delivery, and mentor engineers while balancing customer reliability with...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Lead client interactions and drive technology solutions by leveraging AI and best practices. Collaborate with teams to enhance efficiency, mentor developers, and ensure alignment with business goals w...

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$186K *

Unlock potential by leading the design and delivery of innovative risk systems, optimizing fraud detection and mitigation processes, and mentoring engineers to enhance operational excellence in a dyna...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Join a transformative team as an Engineering Manager to lead engineering initiatives, inspire innovation, and drive technical excellence in revolutionizing healthcare technology while fostering profes...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by building and maintaining CI/CD pipelines, administering servers, and leading DevOps initiatives. Collaborate with teams to enhance application performance and security while men...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $230K *

Join a team that's redefining SoC design by owning subsystem development, integrating third-party IP, and optimizing PPA for next-gen architectures. Contribute across all design stages and drive impac...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$200K - $335K *

Drive strategy and execution for Ads Delivery & Optimization, enhancing advertiser outcomes through advanced bidding, ranking, and measurement systems. Collaborate with cross-functional teams to innov...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Consumer Technology

$183K - $230K *

Lead the charge in shaping our platform strategy, overseeing integrations, pricing, and customer experience. Collaborate with cross-functional teams to enhance product offerings and drive growth in a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$170K - $250K *

Lead the charge in building high-throughput systems as you manage a team of engineers. Drive technical excellence and team growth while collaborating across functions to deliver innovative solutions i...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $215K *

Elevate our cloud infrastructure by developing robust tools for deployment, monitoring, and maintenance. Join a dynamic team of engineers focused on enhancing CI/CD processes and driving developer pro...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Elevate cloud security and reliability by leading DevOps practices across teams. You'll optimize AWS and GCP environments, enhance CI/CD pipelines, and ensure cost-effective engineering tools, driving...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$87K - $209K *

Join a dynamic team to design and implement backend services, enhancing developer tooling and integration frameworks. Drive improvements in performance and resilience while collaborating with cross-fu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$205K - $255K *

Join a team that's shaping the future of data protection by leading the Computer Backup engineering team. Drive technical direction, manage budgets, and enhance collaboration across desktop and backen...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$138K - $165K *

Shape the future of consumer applications by leading machine learning and Generative AI initiatives. Build robust data pipelines, develop and deploy models, and drive business impact through experimen...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Accelerate progress at the intersection of engineering and AI, embedding with enterprise teams to architect and deliver robust AI solutions that meet real-world demands in regulated industries...

Jefferson City, MORemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform the quality landscape of data center equipment by overseeing supplier audits, inspections, and continuous improvement initiatives. Collaborate with cross-functional teams to ensure complianc...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Empower innovation as you design complex electrical systems, lead projects, mentor teams, and ensure high-quality deliverables. Collaborate closely with multi-disciplinary teams, utilizing advanced BI...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Oversee complex electrical design projects and deliver fully constructible BIM models. Collaborate with cross-functional teams, mentor peers, and ensure compliance with safety standards while developi...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Join a team that's shaping the future of consumer payments by designing and building scalable Angular applications. Collaborate across disciplines to create intuitive user experiences while maintainin...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$79K - $133K *

Elevate progress at the forefront of ArcGIS Hub by transforming customer workflows, communicating priorities, and enhancing geospatial collaboration through innovative product management...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Transform AI pilots into secure, reliable production systems by designing innovative solutions and collaborating with cross-functional teams to ensure responsible enterprise adoption of AI technologie...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.