Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Developer - AI Native Engineering
$82K - $123K *
Champion AI innovation by driving tool adoption, engineering practices, and workforce enablement across the enterprise. Collaborate with cross-functional teams, influencing leaders and building future...
Reposted 1 week ago
Senior Manager, Data Engineering
$135K - $160K *
Lead the charge in transforming data accessibility for product teams and AI agents. Oversee a team of data engineers to build a robust platform that ensures secure, reliable data usage across the orga...
6 days ago
Principal AI Security Engineer
$172K - $240K *
Join a team that's redefining AI security! As a Principal AI Security Engineer, you'll lead assessments, design controls, and partner with teams to ensure safe AI adoption across the enterprise, drivi...
3 weeks ago
Learning & Development Senior Program Manager
$145K - $199K *
Lead the charge in shaping innovative learning programs that drive organizational growth. Collaborate with stakeholders to enhance professional development and ensure the strategic execution of initia...
Reposted 2 weeks ago
$120K - $150K *
Drive your career with a dynamic team focused on building innovative products that delight users. As a Product Manager, you'll lead impactful projects, collaborate closely with engineers, and shape th...
1 week ago
Senior Platform Engineer (Infrastructure)
$120K - $145K *
Partner with us to optimize and scale our Ruby on Rails applications, ensuring high availability and performance. Leverage your expertise in cloud infrastructure and Site Reliability Engineering to dr...
Today
$110K - $130K *
Elevate your career by joining a dynamic team focused on validating and optimizing Azure developer desktops. You'll design automated tests, ensure security compliance, and enhance performance metrics...
2 weeks ago
$120K - $140K *
Drive the development and optimization of GTM strategies, leveraging automation and campaign execution across multiple platforms to enhance pipeline generation and account prioritization in a dynamic...
Reposted 1 week ago
Senior Infrastructure Engineer- Secure Developer Platforms (Azure/VDI)
$125K - $150K *
Lead the charge in building a secure, self-service developer sandbox on Azure, delivering non-persistent desktops and managing the entire stack from landing zone to golden image while ensuring complia...
1 week ago
Senior/Lead Forward Deployed AI Engineer/Architect-Copilot/Azure
$135K - $160K *
Unlock innovative AI solutions by deploying and scaling advanced workflows. Collaborate with clients to transform business challenges into reliable, AI-driven applications, leveraging cutting-edge tec...
6 days ago
Security Engineer Lead, Security Foundations
$160K - $190K *
Transform security solutions across multiple domains, driving technical direction and collaboration to address high-risk items and enhance Meta's security posture company-wide. Lead cross-functional t...
1 week ago
Senior Backend Engineer (Integrations & Platform)
$150K - $185K *
Unlock potential by designing and maintaining scalable backend systems for complex data integrations. Collaborate with partners to enhance operational efficiency and reliability, ensuring seamless dat...
1 week ago
Senior Product Manager, Device Experience
$130K - $219K *
Drive the vision for Samsara device installations, enhancing user experiences and ensuring rapid, accurate setups. Collaborate with cross-functional teams to optimize the install process, making impac...
Reposted 2 weeks ago
$120K - $145K *
Lead the charge in developing innovative AI software solutions, enhancing system performance, and collaborating with teams to align with IT roadmaps. Drive improvements through analysis and ensure sea...
Today
$90K - $110K *
Transform project delivery by leading software implementations, ensuring timely and budget-friendly outcomes while fostering strong stakeholder relationships and navigating complex environments with c...
Yesterday
AI First iOS Software Engineer (Remote)
$85K - $125K *
Accelerate progress at the forefront of mobile development by leveraging AI tools to enhance iOS applications. Collaborate with cross-functional teams to deliver high-quality, customer-centric marketp...
3 weeks ago
Senior Site Reliability Engineer
$160K - $208K *
Transform our technology infrastructure by enhancing automation, troubleshooting issues, and fostering collaboration. Bring your expertise to support a scalable infrastructure platform that manages di...
Reposted today
Team Lead, Engineering - Time & Attendance
$160K - $187K *
Transform the Time & Attendance engineering team by leading technical delivery, fostering collaboration, and driving platform modernization to enhance healthcare workforce solutions and ensure data ac...
1 week ago
$170K - $190K *
Shape the future of data engineering by leading architectural improvements, enhancing data quality, and driving technical initiatives across diverse business domains. Collaborate with stakeholders to...
6 days ago
Software Development Engineer II - Back-End (Mission-Focused | ArcGIS)
$97K - $162K *
Unlock your potential by designing scalable backend systems for mission-critical geospatial applications. Collaborate with cross-functional teams to enhance data processing and real-time analytics in...
Today
Director of Customer Experience Operations
$110K - $130K *
Partner with us to transform customer experience operations into a seamless, data-driven journey. Your leadership will unify departments for consistency, enabling effective strategies that enhance cus...
Reposted 2 weeks ago
$199K - $230K *
Drive innovation by deploying and optimizing cloud infrastructure across federal environments. Leverage your expertise in AWS, Kubernetes, and automation tools to enhance platform scalability and secu...
1 week ago
$100K - $120K *
Drive innovation in digital experiences by building and optimizing high-performing web applications. Collaborate with creative teams to enhance customer engagement across platforms while managing the...
3 weeks ago
Staff Engineer, Identity & Access Management (IAM)
$180K - $212K *
Pioneer innovative IAM strategies to enhance security across cloud and on-premise infrastructures. Collaborate with cross-functional teams to implement robust identity governance and access management...
3 weeks ago
$110K - $130K *
Optimize system reliability and performance by leveraging your expertise in cloud SRE. Collaborate with diverse teams to enhance service availability, automate processes, and drive continuous improvem...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.