Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$95K - $115K *

Bring your expertise to develop and maintain payer customer implementations, focusing on backend and frontend development. Collaborate with senior engineers to enhance healthcare applications impactin...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$113K - $170K *

Lead the charge in transforming customer integrations by driving technical discovery, scoping complex implementations, and ensuring successful onboarding for high-stakes accounts. Collaborate closely...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $160K *

Drive the development of critical enterprise applications for DoD personnel, enhancing program and financial management capabilities. Collaborate within a product team to modernize technology and deli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$131K - $200K *

Join a team that's shaping the future of data platforms by developing scalable solutions for analytics and AI workloads. Collaborate on impactful projects using cutting-edge tools to enhance data reli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $110K *

Drive innovation as a Software Engineer III, enhancing full-stack capabilities and mentoring junior developers while collaborating with stakeholders to improve engineering processes and deliver impact...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate team performance by leading a Scrum team in developing and modernizing enterprise SaaS applications. Guide technical decisions, mentor engineers, and foster collaboration across departments to...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$275K - $325K *

Join a team that's redefining financing products through innovative engineering. Lead complex initiatives, modernize systems, and leverage AI tools to enhance software development while ensuring data...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$140K - $160K *

Accelerate innovation by merging creative technology with AI capabilities, driving impactful solutions that enhance workflows and empower teams. Collaborate across disciplines to transform emerging te...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$185K - $312K *

Transform the Agentic Platform as a Principal PM, leading AI agent development across teams. Shape technical direction, enhance developer experience, and ensure seamless integration for impactful cust...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Real Estate & Construction

$105K - $130K *

Unlock potential by leading a dynamic DevOps team to enhance continuous delivery infrastructure, ensuring operational efficiency and security while fostering collaboration and innovation in a fast-pac...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Support manufacturers by implementing solutions that enhance operational performance. Collaborate with teams to drive adoption and deliver measurable improvements, ensuring lasting value from the plat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Empower your software engineering career by directing AI to deliver full-stack solutions. You'll manage end-to-end feature development, leveraging AWS and AI tools to enhance productivity and quality...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $187K *

Transform energy efficiency initiatives by leading a skilled engineering team. Drive project execution, mentor talent, and enhance program delivery across multiple states, ensuring impactful cost savi...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$133K - $209K *

Join a dynamic IT team as you safeguard cloud infrastructure, enhance security measures, and lead incident response efforts. Your expertise will drive continuous improvement and ensure robust protecti...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$154K - $278K *

Drive innovation in advanced maritime technologies, leading multidisciplinary teams to deliver cutting-edge solutions for critical defense missions. Oversee program execution, business development, an...

United StatesRemote

Today

  •   15+ years exp.  •   Technical Services

$120K - $145K *

Champion quality assurance initiatives by leveraging Python and AI-assisted practices. Drive automation improvements, enhance testing efficiency, and collaborate with cross-functional teams to elevate...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$104K - $166K *

Unlock your potential as you build and enhance a cutting-edge data platform, driving innovation in federal background investigations. Collaborate in a high-trust, remote environment while ensuring dat...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$200K - $250K *

Innovate and shape the technical strategy for a cutting-edge exchange platform. Lead high-impact initiatives, mentor engineers, and drive architectural decisions in a regulated environment to enhance...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $225K *

Join a team that's driving innovation in AI by developing scalable backend systems in Go, Python, and Java. Tackle complex challenges while enhancing distributed architectures to empower high-performa...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $163K *

Drive the evolution of software solutions for healthcare quality reporting, leading engineering teams to deliver innovative, high-quality products while fostering a culture of collaboration and contin...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$145K - $175K *

Lead the charge in architecting scalable Azure solutions across multi-team programs, aligning client goals with innovative designs. Mentor teams, drive modernization efforts, and ensure high-quality d...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$175K - $250K *

Shape the cloud infrastructure for AI agents, ensuring secure, scalable solutions that enhance customer workflows. Lead architectural decisions, establish standards, and drive innovation in a dynamic...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$250K - $250K+*

Pioneer the future of developer AI by architecting scalable backend systems that enhance real-world product experiences through developer-centric cloud infrastructure...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Engage in designing and optimizing AI solutions to enhance automation and analytics, collaborating across teams to integrate advanced AI capabilities into core products, while ensuring ethical standar...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.