Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$95K - $115K *
Bring your expertise to develop and maintain payer customer implementations, focusing on backend and frontend development. Collaborate with senior engineers to enhance healthcare applications impactin...
Reposted today
$113K - $170K *
Lead the charge in transforming customer integrations by driving technical discovery, scoping complex implementations, and ensuring successful onboarding for high-stakes accounts. Collaborate closely...
2 weeks ago
CCaR - Senior Software Engineer (Remote)
$140K - $160K *
Drive the development of critical enterprise applications for DoD personnel, enhancing program and financial management capabilities. Collaborate within a product team to modernize technology and deli...
1 week ago
$131K - $200K *
Join a team that's shaping the future of data platforms by developing scalable solutions for analytics and AI workloads. Collaborate on impactful projects using cutting-edge tools to enhance data reli...
1 week ago
Software Engineer III - Full Stack (Drupal)
$105K - $110K *
Drive innovation as a Software Engineer III, enhancing full-stack capabilities and mentoring junior developers while collaborating with stakeholders to improve engineering processes and deliver impact...
Reposted 6 days ago
Team Lead, Software Development
$110K - $130K *
Elevate team performance by leading a Scrum team in developing and modernizing enterprise SaaS applications. Guide technical decisions, mentor engineers, and foster collaboration across departments to...
4 weeks ago
$275K - $325K *
Join a team that's redefining financing products through innovative engineering. Lead complex initiatives, modernize systems, and leverage AI tools to enhance software development while ensuring data...
4 days ago
$110K - $130K *
Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...
5 days ago
$140K - $160K *
Accelerate innovation by merging creative technology with AI capabilities, driving impactful solutions that enhance workflows and empower teams. Collaborate across disciplines to transform emerging te...
2 weeks ago
Principal Product Manager, Agentic AI Platform
$185K - $312K *
Transform the Agentic Platform as a Principal PM, leading AI agent development across teams. Shape technical direction, enhance developer experience, and ensure seamless integration for impactful cust...
Today
$105K - $130K *
Unlock potential by leading a dynamic DevOps team to enhance continuous delivery infrastructure, ensuring operational efficiency and security while fostering collaboration and innovation in a fast-pac...
Today
Manufacturing Solutions Engineer
$80K - $95K *
Support manufacturers by implementing solutions that enhance operational performance. Collaborate with teams to drive adoption and deliver measurable improvements, ensuring lasting value from the plat...
2 weeks ago
$120K - $145K *
Empower your software engineering career by directing AI to deliver full-stack solutions. You'll manage end-to-end feature development, leveraging AWS and AI tools to enhance productivity and quality...
3 weeks ago
$125K - $187K *
Transform energy efficiency initiatives by leading a skilled engineering team. Drive project execution, mentor talent, and enhance program delivery across multiple states, ensuring impactful cost savi...
1 week ago
Senior Security Operations Engineer
$133K - $209K *
Join a dynamic IT team as you safeguard cloud infrastructure, enhance security measures, and lead incident response efforts. Your expertise will drive continuous improvement and ensure robust protecti...
3 weeks ago
$154K - $278K *
Drive innovation in advanced maritime technologies, leading multidisciplinary teams to deliver cutting-edge solutions for critical defense missions. Oversee program execution, business development, an...
Today
Lead Python Test Automation Engineer
$120K - $145K *
Champion quality assurance initiatives by leveraging Python and AI-assisted practices. Drive automation improvements, enhance testing efficiency, and collaborate with cross-functional teams to elevate...
Reposted today
$104K - $166K *
Unlock your potential as you build and enhance a cutting-edge data platform, driving innovation in federal background investigations. Collaborate in a high-trust, remote environment while ensuring dat...
Yesterday
Principal / Senior Staff Backend Engineer
$200K - $250K *
Innovate and shape the technical strategy for a cutting-edge exchange platform. Lead high-impact initiatives, mentor engineers, and drive architectural decisions in a regulated environment to enhance...
1 week ago
Senior AI Product Engineer, Backend
$125K - $225K *
Join a team that's driving innovation in AI by developing scalable backend systems in Go, Python, and Java. Tackle complex challenges while enhancing distributed architectures to empower high-performa...
Reposted 4 days ago
$138K - $163K *
Drive the evolution of software solutions for healthcare quality reporting, leading engineering teams to deliver innovative, high-quality products while fostering a culture of collaboration and contin...
Reposted today
Senior Architect - Data Platforms & Architecture
$145K - $175K *
Lead the charge in architecting scalable Azure solutions across multi-team programs, aligning client goals with innovative designs. Mentor teams, drive modernization efforts, and ensure high-quality d...
3 days ago
Principal Cloud Engineer - AI Platform
$175K - $250K *
Shape the cloud infrastructure for AI agents, ensuring secure, scalable solutions that enhance customer workflows. Lead architectural decisions, establish standards, and drive innovation in a dynamic...
Reposted 3 days ago
Member of Engineering, Backend - AI
$250K - $250K+*
Pioneer the future of developer AI by architecting scalable backend systems that enhance real-world product experiences through developer-centric cloud infrastructure...
Reposted 3 days ago
$135K - $160K *
Engage in designing and optimizing AI solutions to enhance automation and analytics, collaborating across teams to integrate advanced AI capabilities into core products, while ensuring ethical standar...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.