Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$150K - $180K *

Drive the technical design and delivery of innovative AI agent solutions, leading a team to ensure operational readiness and quality. Collaborate with stakeholders to define requirements and guide eng...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $135K *

Engineer robust Kubernetes/OpenShift solutions, collaborating across teams to enhance container platform operations. Drive onboarding, maintain clusters, and optimize CI/CD pipelines for seamless appl...

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$99K - $167K *

Develop and maintain robust data pipelines using SparkSQL and Pyspark, ensuring high-quality data for analytics. Collaborate with cross-functional teams to enhance data analysis efficiency and support...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Join a dynamic team to drive technical vision and operational excellence in cloud-native platforms. Lead engineering efforts, champion security practices, and empower talent while ensuring system stab...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$222K - $314K *

Drive innovation by designing and implementing LLM-based systems that tackle complex problems in data processing, empowering the team with your technical direction and expertise while overseeing impac...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$170K - $205K *

Unlock the potential of our Pro offering by leading product strategy and roadmap. Collaborate across teams to enhance customer experiences for short-term rental operators and HOAs, ensuring scalable s...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$110K - $130K *

Optimize enterprise solutions by developing and integrating AI-powered agents using Microsoft Power Platform. Ensure secure, maintainable, and production-ready applications that enhance business proce...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Engage in the design and management of enterprise endpoint technologies, ensuring security and efficiency across over 1,000 devices. Collaborate with cross-functional teams to enhance endpoint perform...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$133K - $156K *

Drive the development and modernization of core banking applications, leading a team of engineers to ensure system stability, operational efficiency, and alignment with business objectives while foste...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Join a team that's building and scaling a data and analytics platform to enhance clinical AI performance. Collaborate with cross-functional teams to create actionable insights and drive improvements i...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$96K - $120K *

Accelerate progress at the forefront of digital banking by leading complex client implementations, resolving advanced technical issues, and ensuring successful delivery of innovative solutions that al...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $175K *

Lead the charge in engineering management, guiding a cross-functional team of 4-7 engineers. Drive execution, foster growth, and ensure quality while collaborating closely with product management to d...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Elevate your career by managing technical programs across global engineering teams. Drive alignment, enhance decision-making, and leverage AI to optimize workflows while supporting senior leadership i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$202K - $253K *

Drive the development of AI-driven coaching solutions, overseeing multiple squads from prototype to production. Ensure quality delivery, manage resources effectively, and foster team growth while main...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$102K - $209K *

Empower your career by leading end-to-end data center programs, ensuring seamless delivery from site selection to operational handover. Collaborate with diverse teams and manage complex projects to dr...

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $145K *

Optimize software development by owning complex features, leveraging AI tools, and collaborating with cross-functional teams to deliver high-quality, scalable solutions that meet business needs and te...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$144K - $165K *

Unlock potential by owning data architecture and reliability across domains. Collaborate with an AI-first team to design robust data pipelines, enhance analytics, and drive impactful solutions in a dy...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive operational excellence by enhancing system reliability and automation. Collaborate with teams to minimize downtime, optimize performance, and implement innovative solutions that ensure high avai...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Join a dynamic team to enhance system reliability and performance through automation, ensuring minimal downtime and optimal user experience while driving continuous improvements in a cutting-edge tech...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$143K - $194K *

Pioneer innovative strategies for a Virtual First work stream, enhancing employee effectiveness through technology and research. Lead cross-functional initiatives, manage complex programs, and drive m...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Consumer Technology

$120K - $160K *

Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$138K - $165K *

Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $193K *

Engage in architecting and designing digital products, leading teams to implement innovative software solutions while ensuring accountability for product success and performance metrics...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $200K *

Lead the charge in modernizing backend capabilities and AWS infrastructure, ensuring secure, reliable software development at scale. Collaborate with teams to enhance platform usability and drive prod...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Staffing

$101K - $112K *

Lead the charge in managing complex projects within the Education portfolio, ensuring effective coordination across teams and stakeholders while driving impactful outcomes in higher education and appl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.