Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$150K - $180K *
Drive the technical design and delivery of innovative AI agent solutions, leading a team to ensure operational readiness and quality. Collaborate with stakeholders to define requirements and guide eng...
Reposted 4 weeks ago
$90K - $135K *
Engineer robust Kubernetes/OpenShift solutions, collaborating across teams to enhance container platform operations. Drive onboarding, maintain clusters, and optimize CI/CD pipelines for seamless appl...
2 weeks ago
$99K - $167K *
Develop and maintain robust data pipelines using SparkSQL and Pyspark, ensuring high-quality data for analytics. Collaborate with cross-functional teams to enhance data analysis efficiency and support...
4 weeks ago
Senior Engineering Manager, Containers
$150K - $180K *
Join a dynamic team to drive technical vision and operational excellence in cloud-native platforms. Lead engineering efforts, champion security practices, and empower talent while ensuring system stab...
3 weeks ago
Staff Backend Engineer - Submission Processing
$222K - $314K *
Drive innovation by designing and implementing LLM-based systems that tackle complex problems in data processing, empowering the team with your technical direction and expertise while overseeing impac...
Reposted 4 days ago
Principal Product Manager, Pro
$170K - $205K *
Unlock the potential of our Pro offering by leading product strategy and roadmap. Collaborate across teams to enhance customer experiences for short-term rental operators and HOAs, ensuring scalable s...
6 days ago
Senior Power Platform Developer/AI Automation Engineer
$110K - $130K *
Optimize enterprise solutions by developing and integrating AI-powered agents using Microsoft Power Platform. Ensure secure, maintainable, and production-ready applications that enhance business proce...
Yesterday
$110K - $130K *
Engage in the design and management of enterprise endpoint technologies, ensuring security and efficiency across over 1,000 devices. Collaborate with cross-functional teams to enhance endpoint perform...
3 weeks ago
Software Engineering Manager 3 (Hogan Banking Platform)
$133K - $156K *
Drive the development and modernization of core banking applications, leading a team of engineers to ensure system stability, operational efficiency, and alignment with business objectives while foste...
Reposted 2 days ago
Software Engineer, Data & Analytics Platform
$120K - $145K *
Join a team that's building and scaling a data and analytics platform to enhance clinical AI performance. Collaborate with cross-functional teams to create actionable insights and drive improvements i...
6 days ago
Sr. Implementation Engineer (MANTL)
$96K - $120K *
Accelerate progress at the forefront of digital banking by leading complex client implementations, resolving advanced technical issues, and ensuring successful delivery of innovative solutions that al...
3 weeks ago
$145K - $175K *
Lead the charge in engineering management, guiding a cross-functional team of 4-7 engineers. Drive execution, foster growth, and ensure quality while collaborating closely with product management to d...
6 days ago
Software Engineering Program Manager
$120K - $145K *
Elevate your career by managing technical programs across global engineering teams. Drive alignment, enhance decision-making, and leverage AI to optimize workflows while supporting senior leadership i...
1 week ago
Senior Engineering Manager, Co-Intelligent Coaching
$202K - $253K *
Drive the development of AI-driven coaching solutions, overseeing multiple squads from prototype to production. Ensure quality delivery, manage resources effectively, and foster team growth while main...
Today
Principal Technical Program Manager, Data Centers
$102K - $209K *
Empower your career by leading end-to-end data center programs, ensuring seamless delivery from site selection to operational handover. Collaborate with diverse teams and manage complex projects to dr...
6 days ago
$115K - $145K *
Optimize software development by owning complex features, leveraging AI tools, and collaborating with cross-functional teams to deliver high-quality, scalable solutions that meet business needs and te...
2 weeks ago
Senior Engineer, Data Engineering
$144K - $165K *
Unlock potential by owning data architecture and reliability across domains. Collaborate with an AI-first team to design robust data pipelines, enhance analytics, and drive impactful solutions in a dy...
6 days ago
$110K - $130K *
Drive operational excellence by enhancing system reliability and automation. Collaborate with teams to minimize downtime, optimize performance, and implement innovative solutions that ensure high avai...
1 week ago
$110K - $130K *
Join a dynamic team to enhance system reliability and performance through automation, ensuring minimal downtime and optimal user experience while driving continuous improvements in a cutting-edge tech...
1 week ago
Senior Program Manager, Employee Experience
$143K - $194K *
Pioneer innovative strategies for a Virtual First work stream, enhancing employee effectiveness through technology and research. Lead cross-functional initiatives, manage complex programs, and drive m...
Reposted yesterday
$120K - $160K *
Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...
4 days ago
Senior AI Engineer with RAG and Agentic architectures
$138K - $165K *
Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...
Reposted 4 days ago
Managing Engineer, Software Engineering -Remote
$120K - $193K *
Engage in architecting and designing digital products, leading teams to implement innovative software solutions while ensuring accountability for product success and performance metrics...
4 weeks ago
Senior Platform Software Engineer
$150K - $200K *
Lead the charge in modernizing backend capabilities and AWS infrastructure, ensuring secure, reliable software development at scale. Collaborate with teams to enhance platform usability and drive prod...
5 days ago
$101K - $112K *
Lead the charge in managing complex projects within the Education portfolio, ensuring effective coordination across teams and stakeholders while driving impactful outcomes in higher education and appl...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.