Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$135K - $204K *

Unlock your potential by developing innovative software solutions in avionics. Collaborate with cross-functional teams to create high-quality prototypes and scalable applications, driving advancements...

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$165K - $204K *

Lead cross-functional teams to develop and enhance avionics software, ensuring compliance with safety standards while managing project quality, cost, and schedule. Engage in feature development and te...

4 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$150K - $185K *

Take ownership of our cloud and backend infrastructure, driving technical direction and improvements. Lead a team to ensure reliability and scalability of systems supporting our games and analytics, w...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$105K - $120K *

Join a team that's driving successful ERP and CRM software implementations. Lead projects, coordinate teams, and ensure timely delivery while achieving sales and profit targets. Collaborate with stake...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Media

$218K - $256K *

Drive the architectural vision for high-scale fund movement systems, enhancing reliability and scalability. Lead cross-functional initiatives that impact millions, ensuring financial integrity and ope...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Empower our team to build innovative security and governance solutions, shaping access management for both human and agent users. Lead a small, dynamic group as we define architectural foundations and...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $215K *

Transform the engineering landscape by leading Infrastructure teams focused on CI/CD and Kubernetes. Drive platform consolidation, enhance operational efficiency, and foster a customer-centric environ...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$73K - $102K *

Unlock potential by leading the development of LLM-powered applications and agentic systems. Collaborate across teams to design, implement, and maintain innovative software solutions, ensuring high qu...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Elevate your career by driving strategic programs that enhance our Extensibility platform. Collaborate across teams to shape product roadmaps and ensure successful launches while addressing complex cu...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$157K - $180K *

Join a team that's driving innovation by building AI-powered tools for a vibrant community of diverse software engineers. You'll blend hands-on engineering with community management to enhance technic...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Join a dynamic team as you lead mobile development in an AI-first environment. Drive innovation, mentor engineers, and shape user experiences across platforms while collaborating closely with product...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$132K - $251K *

Lead the charge in shaping mission-critical avionics software for the KC-46 Video Graphics System. Drive a high-performing team to deliver robust, certifiable software that enhances aircrew situationa...

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$107K - $161K *

Innovate in R&D as a Senior Systems Engineer, bridging early-stage tech and production. Drive feasibility studies, prototype emerging features, and collaborate with partners to advance next-gen archit...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$114K - $191K *

Lead the charge in shaping high-impact SaaS solutions by driving technical strategy and empowering a high-performing engineering team. Collaborate across disciplines to foster innovation in a fast-pac...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$149K - $240K *

Help us build robust data foundations by designing Postgres schemas and optimizing transactional models. Collaborate with teams to ensure reliable data systems and mentor engineers in data fluency, en...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Unlock potential by designing and delivering scalable AI-powered integrations for nonprofits. Collaborate closely with clients to understand their needs, build solutions, and productize offerings that...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $170K *

Develop and enhance Python services for pharmacy claims processing. Collaborate across teams to deliver high-quality solutions while gaining expertise in the pharmacy benefits domain. Embrace a hybrid...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $145K *

Drive innovative software solutions by developing robust, cloud-native systems that enhance provider data management capabilities and meet the evolving needs of clients in a dynamic, collaborative env...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Join a team that's at the forefront of machine learning and search innovation. Collaborate with cross-functional teams to develop scalable ML systems that enhance user experiences and drive impactful...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $155K *

Empower innovation by leading hardware engineering efforts across cloud and data center environments, ensuring optimal performance and reliability of compute, storage, and GPU platforms while collabor...

1 month ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Champion innovative AI platform architecture and drive enterprise-level integration of machine learning, ensuring security, accuracy, and reliability across systems while mentoring teams to elevate te...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$150K - $180K *

Transform the architecture of diverse security platforms, guiding teams through complex design challenges while ensuring scalable, secure, and maintainable systems across multiple product areas in a h...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$114K - $145K *

Unlock your potential as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managin...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$130K - $200K *

Drive impactful design and development of front-end features, owning the code from concept to production. Collaborate with teams to establish design systems and set direction for user-centric products...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$180K - $215K *

Lead the design and development of AI-driven acquisition systems, creating automated workflows and optimizing audience targeting to enhance customer engagement and retention in a data-rich environment...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.