Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$150K - $180K *

Shape the future of semantic technologies by guiding teams in architecting scalable data solutions. Collaborate across functions to define ontologies and drive enterprise-wide data strategy while ment...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Unlock potential by leading our Site Reliability Engineering team, ensuring the reliability and performance of our cloud-native platform. Drive technical excellence, cultivate a high-performance cultu...

RemoteRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Accelerate progress at the forefront of embedded software development, driving innovation in optical networking. Collaborate with cross-functional teams to enhance product performance and deliver cutt...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$75K - $100K *

Drive operational excellence by managing maintenance and field service projects, ensuring timely delivery and compliance with safety standards while collaborating with cross-functional teams to enhanc...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$217K - $303K *

Innovate the future of iOS development by architecting scalable solutions for Reddit's mobile app. Lead technical direction, mentor engineers, and enhance developer efficiency to support 100M+ DAUs wh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$120K - $145K *

Lead the Validation and Process Engineering teams to ensure compliance and efficiency in pharmaceutical manufacturing. Oversee equipment validation, project management, and cross-department collaborat...

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$145K - $175K *

Elevate security initiatives by leading IAM and cloud security efforts in a dynamic, remote environment. Collaborate with engineering teams to enhance application security and drive modernization acro...

Reposted today

  •   8 - 10 years exp.  •   Staffing

$106K - $284K *

Reimagine healthcare technology by leading the development of secure, scalable microservices. Collaborate with cross-functional teams to enhance digital solutions that transform patient experiences an...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$106K - $284K *

Join a team that’s redefining pharmacy and healthcare through innovative digital solutions. As a Staff Software Development Engineer, you'll lead in creating next-generation platforms, ensuring qualit...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$106K - $284K *

Champion the design and development of scalable applications, integrating AI and data systems. Lead technical strategy, mentor teams, and ensure operational excellence across the technology stack whil...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$106K - $284K *

Reimagine application development by leading architecture and scaling core systems. Drive AI integration, mentor teams, and ensure operational excellence across full-stack technologies while deliverin...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$165K - $185K *

Accelerate progress at the forefront of test automation, driving quality and performance through innovative strategies and frameworks. Collaborate within an agile team to enhance product scalability a...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$128K - $252K *

Lead the charge in building and managing high-performing software engineering teams. Drive innovation, optimize processes, and deliver high-quality applications while fostering a culture of excellence...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$114K - $252K *

Unlock potential by leading software development initiatives, ensuring system integration, and guiding teams through agile methodologies to deliver high-quality solutions that meet customer requiremen...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Lead cutting-edge AI research in video analysis and game analytics, transforming sports experiences for fans. Collaborate with academic experts to innovate, publish, and bridge the gap between researc...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$95K - $115K *

Elevate your career by driving innovative application development in engineered materials. Collaborate across teams to lead R&D projects, enhance product capabilities, and support market growth in bui...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Business Services

$160K *

Drive enterprise-level implementations of phishing-resistant authentication solutions, leading technical deployments and integrations across various identity platforms while ensuring customer success...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Elevate enterprise solutions by leading the design and development of scalable applications using Microsoft Dynamics 365 and Power Platform. Drive engineering excellence while mentoring a team to ensu...

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $275K *

Lead the development of off-board AI evaluation frameworks to optimize safety and performance for autonomous vehicles. Collaborate with cross-functional teams to design scalable systems and enhance di...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Transportation

$120K - $145K *

Join a dynamic team to build and automate security controls across our infrastructure. You'll manage host hardening, vulnerability assessments, and compliance, leveraging AI tools to enhance security...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$186K - $242K *

Empower innovation at a rapidly growing team, leading API architecture and integrations. Collaborate across teams to enhance platform capabilities while mentoring engineers and ensuring system reliabi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$109K - $141K *

Lead the charge in delivering innovative ServiceNow SPM solutions, collaborating with cross-functional teams to enhance product capabilities and drive operational excellence while ensuring adherence t...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Partner with us to bridge technical solutions and customer needs in a dynamic, cross-functional role. Utilize your expertise to drive adoption of AI agents, influencing product roadmaps and enhancing...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $144K *

Lead the charge in designing and implementing advanced building automation systems for critical infrastructure projects, ensuring seamless integration and optimal performance while managing teams and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Transform cloud services by providing expert guidance on secure architecture, risk management, and agile workflows. Mentor teams and enhance collaboration while ensuring compliance with federal standa...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.