Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$157K - $232K *

Lead the charge in building scalable data infrastructure for analytics. Collaborate with cross-functional teams to enhance data architecture, drive AI/ML initiatives, and establish governance across t...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Finance & Insurance

$70K - $110K *

Deliver exceptional service by installing, maintaining, and troubleshooting analytical instruments. Collaborate with customers to optimize performance and ensure satisfaction while supporting business...

Pennsylvania, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$173K - $233K *

Lead the design and scaling of large-scale distributed SQL databases, enhancing infrastructure reliability and performance. Collaborate with cross-functional teams to drive innovative solutions and en...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$198K - $233K *

Empower a team of engineers by architecting a robust AI-driven development pipeline, enhancing workflows across mobile and backend systems, and ensuring reliable, efficient software delivery for milli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$100K - $120K *

Drive the development and integration of advanced nuclear energy systems by applying systems engineering methods to translate objectives into clear, verifiable requirements and solutions, while collab...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$225K - $281K *

Lead detection and response strategy, building systems and automations to enhance security. Collaborate with teams to set standards, mentor engineers, and manage complex incidents, ensuring effective...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Empower engineering teams by building robust test automation solutions that enhance productivity. Design and own comprehensive frameworks that streamline workflows, and collaborate with product teams...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $125K *

Deliver impactful project management by leading multi-disciplinary teams, ensuring timely and budget-compliant execution of industrial projects while fostering strong client relationships and maintain...

6 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Champion modernization initiatives by designing and overseeing transformation solutions, integrating cutting-edge GenAI technology, and ensuring alignment with business objectives to drive impactful m...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Grow your career with a role focused on enhancing our external and cloud security by managing penetration testing and vulnerability assessments, ensuring the protection of vital assets against emergin...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$90K - $110K *

Shape user experiences by designing intuitive interfaces for a cutting-edge security platform. Collaborate with engineers to create impactful visual workflows, leveraging modern technologies to enhanc...

Devault, PARemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Join a dynamic team as a Project Engineer, driving innovative medical device projects from concept to commercialization while collaborating with cross-functional teams and engaging with customers to e...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a team that's transforming healthcare automation by leading the design and delivery of intelligent solutions in Revenue Cycle Management, specializing in computer vision-driven RPA to enhance ope...

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$118K - $180K *

Unlock potential by leading structural engineering reviews for renewable energy projects. Collaborate with multi-discipline teams to optimize design, support financing, and deliver actionable insights...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Technical Services

$140K - $200K *

Shape the future of mixed-signal IC design by leading EDA/CAD efforts. Collaborate with a skilled team to drive innovative solutions from concept to production, ensuring high-performance layouts and t...

Yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Shape the future of cloud security solutions by leading technical sales pursuits, collaborating with clients and internal teams to deliver tailored compliance strategies and drive successful implement...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$212K - $265K *

Advance your career by leading the design of scalable insurance systems, collaborating with cross-functional teams to enhance product offerings and drive technical excellence in a dynamic environment...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$110K - $130K *

Lead the charge in optimizing cloud environments as a DevOps Engineer. Collaborate across teams to enhance AWS infrastructure, automate processes, and ensure high availability and security for Java ap...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Transform your career by leading the technical direction for data visualization. Collaborate with a skilled team to design and build innovative visualization components, enhancing customer interaction...

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Transform data services by developing and modernizing ETL processes, data integration, and warehousing solutions. Collaborate with cross-functional teams to enhance data quality and performance in a h...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$140K - $160K *

Drive the development of critical enterprise applications for defense personnel, utilizing Java, Spring Boot, and Angular. Collaborate in an agile team to enhance program and financial management tool...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$220K - $290K *

Accelerate the development of autonomous systems by leading systems engineering strategies, aligning cross-functional teams, and ensuring rigorous safety and performance standards throughout the produ...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$118K - $219K *

Transform your career by leading the integration and testing of advanced satellite systems. Collaborate with diverse teams to ensure robust solutions, driving technical planning and validation for nex...

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$113K - $140K *

Champion the reliability and performance of critical systems, driving architecture evolution and incident response. Collaborate with a skilled team across AWS and Azure, ensuring security and scalabil...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $135K *

Shape the future of IoT solutions by leading backend cloud services development. Drive technical design, mentor engineers, and ensure scalable architecture for AWS-based applications while enhancing u...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.