Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$180K *

Empower clients through expert claims management, ensuring fair coverage interpretation and efficient resolutions while fostering strong relationships and strategic advocacy throughout the property an...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K *

Unlock growth by leading sales initiatives with financial intermediaries, developing strategies to enhance client relationships, and driving MFS Investment products across diverse channels to achieve...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Champion new business development by identifying and converting revenue opportunities across enterprise customers and technology partners, driving growth and establishing long-term relationships in a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Help us shape the future of information security and AI governance by supporting strategic initiatives, managing cybersecurity policies, and conducting digital forensics to ensure compliance and risk...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$65K - $96K *

Join our team to manage complex compliance filings, ensuring accuracy and quality standards. You'll mentor others, review peer work, and develop processes to enhance service delivery within compliance...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$65K - $96K *

Empower compliance processes by preparing complex government filings, mentoring team members, and ensuring accuracy, while maintaining high service standards and developing knowledge of intricate comp...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$156K - $195K *

Champion the global eDiscovery Technology practice, leading a diverse team to innovate AI-assisted workflows, ensuring defensibility and quality across jurisdictions while driving growth and operation...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$106K - $197K *

Join a team that's dedicated to empowering customers in global trade. As a Customer Success Manager, you'll leverage your expertise to drive client success, foster relationships, and ensure optimal va...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$110K - $145K *

Grow your career with a dynamic role managing trust accounts, ensuring compliance, and delivering exceptional client service while collaborating with financial professionals to enhance trust relations...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$61K - $129K *

Lead legal research and support for AUSAs, analyzing complex cases and drafting documents. Collaborate with attorneys to ensure compliance with laws and procedures while managing habeas corpus and imm...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$126K - $188K *

Accelerate progress at the forefront of operational risk enablement, leading regional teams to implement enterprise standards, build capabilities, and foster relationships across diverse stakeholders...

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $140K *

Drive impactful financial due diligence for M&A activities, collaborating with clients and executives to assess enterprise value and risks. Join a high-performing team dedicated to excellence in deal...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$125K - $150K *

Accelerate progress at building a world-class AI Receptionist partner ecosystem, driving revenue and customer success through strategic enablement programs. Collaborate cross-functionally to enhance p...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$119K - $149K *

Lead full-cycle recruiting for technical and analytical roles, partnering with teams to define success and build diverse talent pipelines. Utilize creative sourcing and data-driven insights to enhance...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K *

Tackle complex sales challenges by driving revenue growth through strategic account management and new business development. Collaborate with internal teams to deliver exceptional client service and l...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$160K - $190K *

Shape the future of commercial law by leading negotiations and advising on product launches. Collaborate with cross-functional teams to enhance legal processes and support strategic growth initiatives...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$126K - $188K *

Drive operational risk enablement across regions by translating enterprise frameworks, building practitioner capabilities, and ensuring compliance with local regulations while fostering strong stakeho...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$89K - $142K *

Unlock potential by providing expert audit and advisory services to enhance risk management and internal controls across subsidiaries, ensuring effective governance and operational efficiency in a dyn...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Lead the end-to-end recruiting process, enhancing strategies and partnerships across departments. Drive high-volume hiring with autonomy, ensuring a seamless candidate experience while collaborating c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$197K - $328K *

Shape the future of pharmacy network operations by leading a team of attorneys, providing strategic legal counsel on regulatory, operational, and transactional matters within the PBM landscape, while...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $100K *

Grow your career with a dynamic team focused on residential mortgage origination. Lead initiatives to develop talent, manage loan processes, and ensure exceptional customer experiences while achieving...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $132K *

Join a team that's dedicated to enhancing cybersecurity measures across cloud environments. Lead initiatives in data protection, compliance, and security awareness while mentoring peers and implementi...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$140K - $160K *

Join a team that's dedicated to managing complex general liability claims, focusing on Construction and specialty lines. Drive strategic claim resolutions, ensure compliance, and enhance customer sati...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$110K - $145K *

Strategize initiatives to enhance workforce alignment and Agile practices, driving high performance in IT services for federal clients while fostering a collaborative culture and supporting strategic...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $450K *

Inspire innovation in global therapeutic strategies, leading scientific expertise and operational execution across a diverse therapeutic landscape, while ensuring high-quality delivery and compliance...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.