Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Principal Consultant - Education Cloud Architect
$125K - $150K *
Drive transformative Salesforce solutions in higher education as a trusted advisor. Lead architecture design, align technology with institutional goals, and ensure successful delivery of Education Clo...
4 weeks ago
Associate Creative Director, Copy - Healthcare Advertising
$121K - $155K *
Invent compelling narratives and lead creative development across multiple brands. Collaborate with teams to ensure strategic alignment, mentor junior staff, and engage clients effectively to elevate...
Today
Engineering Manager, Federal & Regulated Infrastructure
$215K - $315K *
Lead the charge in building secure, compliant infrastructure for our DaaS platform. Drive engineering excellence while collaborating with cross-functional teams to meet the needs of regulated customer...
2 weeks ago
$120K - $145K *
Lead the charge in transforming complex revenue-cycle challenges into robust, production-ready AI models, ensuring statistical integrity and operational reliability while managing end-to-end data pipe...
Reposted 4 days ago
Senior Product Manager, Enterprise (Remote)
$200K - $250K *
Pioneer innovative solutions in enterprise healthcare by owning product development, enhancing EMR integrations, and streamlining implementations to ensure rapid adoption and customer satisfaction acr...
4 weeks ago
Senior AI Engineer - Data & MLOps (Teradyne, Remote)
$133K - $223K *
Lead the design and operationalization of ML/AI solutions, ensuring production readiness and supportability. Collaborate with IT teams to solve business challenges and drive innovation through scalabl...
Reposted 1 week ago
$69K - $101K *
Champion the reliability of automated systems by providing expert technical support, troubleshooting complex issues, and collaborating cross-functionally to ensure operational excellence and seamless...
2 weeks ago
Global Head of Customer Success Engineering
$242K - $285K *
Transform the customer success landscape by leading technical teams, driving integration health, and enhancing revenue through strategic partnerships and innovative solutions in the programmatic ecosy...
1 week ago
Principal AI Architect - Remote
$150K - $180K *
Shape the future of AI solutions by architecting innovative end-to-end systems, mentoring teams, and driving best practices in a collaborative environment focused on enterprise-level delivery and gove...
Reposted 1 week ago
$88K - $105K *
Join a team that's dedicated to enhancing client financial performance through accurate forecasting, variance analysis, and innovative automation. Collaborate with cross-functional teams to drive budg...
1 week ago
Senior Java Software Engineer (Library of Congress)
$115K - $135K *
Lead the charge in developing high-quality software solutions, mentoring engineers, and driving process improvements. Collaborate with stakeholders to enhance systems and deliver impactful results in...
Reposted 2 days ago
Environmental Services Market Sector Leader
$180K - $220K *
Lead the charge in strategic growth and operational excellence within the environmental services market, driving talent development, optimizing project delivery, and enhancing client relationships acr...
Reposted today
Journeyman Management Analyst (Modeler)
$100K - $115K *
Transform stakeholder insights into actionable solutions by gathering and analyzing business requirements. Collaborate with teams to create process models and ensure compliance, delivering high-qualit...
2 weeks ago
$140K - $160K *
Elevate financial planning and analysis as you lead consolidated forecasts, enhance reporting quality, and partner with executives to drive strategic decisions. Utilize AI and automation to optimize p...
Reposted 2 days ago
Senior/Staff Developer Experience Engineer
$199K - $270K *
Shape the future of software development by enhancing tooling, CI/CD, and operational workflows, ensuring teams can seamlessly transition code changes into production with improved speed, quality, and...
Reposted 2 days ago
Principal Consultant - AI Infrastructure Services
$188K - $244K *
Shape your career as a Principal Consultant, leading AI infrastructure transformations. Drive strategic initiatives, mentor teams, and deliver executive insights to optimize data center design and enh...
Reposted 1 week ago
Principal Consultant - AI Infrastructure Services
$177K - $229K *
Drive impactful AI transformations by leading strategic consulting initiatives. Collaborate with executives to optimize cloud architecture and deliver value-driven solutions, while mentoring teams and...
Reposted 1 week ago
Principal Consultant - AI Infrastructure Services
$197K - $255K *
Lead the charge in AI transformation by optimizing data center design and accelerating value realization. Serve as a subject-matter expert, guiding strategic implementations and mentoring teams to dri...
Reposted 1 week ago
Principal Consultant - AI Infrastructure Services
$216K - $280K *
Transform AI infrastructure by leading strategic consulting initiatives, guiding executives through architecture and value realization, and mentoring teams to optimize cloud integration and data archi...
Reposted 1 week ago
Senior Business Applications Engineer
$150K - $200K *
Lead the charge in transforming business challenges into innovative solutions by leveraging your expertise in automation and integration. Collaborate across teams to enhance operational efficiency and...
1 week ago
$150K - $180K *
Elevate your career as a Group Director, leading B2B client success and team performance. Drive client retention and growth, enhance strategic initiatives, and shape the division's vision in a dynamic...
Reposted 1 week ago
Subject Matter Expert - Remote Sensing/Nuclear Detection Activity
$150K - $180K *
Drive expertise in remote sensing and nuclear detection to analyze, evaluate, and communicate critical intelligence on nuclear proliferation. Collaborate with teams across sectors to enhance detection...
Reposted 2 weeks ago
$90K - $110K *
Advance your career by providing essential maintenance and support for cyclotrons and analytical equipment, ensuring optimal performance in a dynamic oncology environment. Collaborate on quality contr...
3 weeks ago
Field Application Specialist, dPCR (Southern California)
$100K - $120K *
Engage with customers by providing expert support for digital PCR instruments. Drive installations, training, and troubleshooting while collaborating with sales teams to enhance customer satisfaction...
1 week ago
Associate Scientific Director, Medical Communications
$110K - $140K *
Unlock potential by translating complex scientific data into clear, impactful communication. Collaborate across teams to shape strategy and elevate medical communications that enhance patient outcomes...
Reposted 6 days ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.