Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Clinical Development Medical Director, Early Development - Cardiometabolic
$274K - $371K *
Lead the early phase clinical development of innovative therapeutics, collaborating across teams to design and execute trials. Your expertise will directly influence strategy, protocol development, an...
Reposted 2 weeks ago
Director, Global EPM COE, Application Management
$165K - $237K *
Lead the charge in managing and optimizing global financial systems, ensuring seamless integration and governance across applications. Drive strategic initiatives and collaborate with cross-functional...
Today
Associate Director, Site Monitoring
$154K - $242K *
Elevate your career by leading site monitoring activities across clinical studies, ensuring compliance, quality, and timely delivery while developing high-performing teams and driving innovative monit...
Reposted today
$140K - $165K *
Drive innovative fraud risk management solutions by leveraging advanced machine learning and data analytics. Collaborate with stakeholders to enhance model development and mentor junior data scientist...
3 weeks ago
Principal Technical Consultant-Federal
$165K - $289K *
Transform customer engagement by leading integration strategies and solutions, leveraging AI technologies to enhance business outcomes and drive satisfaction on the ServiceNow platform through expert...
2 days ago
Product Manager, New Content Initiatives and Analysis
$140K - $175K *
Transform investment research by evaluating and integrating diverse datasets, enhancing AI-driven workflows, and driving strategic content initiatives to elevate platform value and user experience...
2 weeks ago
$130K - $163K *
Shape the future of AI in our organization as a strategic leader driving enterprise-wide adoption and integration of AI technologies, enhancing productivity and delivering measurable results through i...
Reposted 1 month ago
Senior Project Manager, PDS Projects
$120K - $132K *
Take ownership of multiple projects across various phases in financial services, ensuring timely delivery, budget adherence, and stakeholder satisfaction while leading cross-functional teams and drivi...
3 weeks ago
$110K - $130K *
Elevate product execution by translating client needs into actionable requirements, collaborating with engineering and data science teams to deliver standardized measurement solutions across various c...
1 week ago
Principal Security Compliance Specialist
$132K - $237K *
Join a dynamic team to architect and implement global security compliance frameworks, driving enterprise-wide initiatives and ensuring adherence to regulatory standards across complex cloud environmen...
3 weeks ago
Senior Director / Executive Director, Forecasting & New Product Planning
$285K - $320K *
Transform your career by leading commercial forecasting and strategic market analytics. Collaborate with executives to drive insights, shape narratives, and influence decisions that impact the company...
6 days ago
$197K - $240K *
Join us to define and own the product strategy for Wallets, shaping the future of stablecoin and payment solutions. Collaborate across teams to drive customer adoption and business impact through inno...
3 weeks ago
Oracle EPM Senior Project Manager
$120K - $145K *
Lead Oracle Cloud EPM projects, ensuring timely delivery and high quality. Collaborate with stakeholders and manage resources to achieve project objectives, fostering team success and effective commun...
Reposted 3 weeks ago
Account Executive, Life Sciences & Medtech
$147K - $220K *
Champion transformative health solutions by managing key client relationships, driving sales, and collaborating across teams to enhance Verily's impact in Life Sciences. Leverage expertise to unlock n...
4 weeks ago
$108K - $130K *
Lead product security and compliance initiatives, ensuring clients meet regulatory standards across diverse sectors. Drive client engagement, deliver assessments, and enhance cybersecurity resilience...
Reposted yesterday
Associate Director, Regulatory Affairs - In Vitro Diagnostics and Digital Health
$179K - $293K *
Drive regulatory strategies for In Vitro Diagnostics and Digital Health, overseeing development, submissions, and commercialization. Collaborate with stakeholders and lead health authority meetings to...
3 days ago
$150K - $180K *
Transform compensation and rewards at scale, ensuring fairness and clarity across global teams. Collaborate with leadership to design and implement effective pay structures, cycles, and equity guideli...
Reposted today
Lead Electrical and Controls Engineer - Paper Industry
$110K - $140K *
Provide technical leadership in electrical and controls engineering for industrial projects, ensuring high-quality design and integration of systems while collaborating with clients and teams to drive...
6 days ago
Sr Program Manager, Client Delivery
$155K - $180K *
Drive successful delivery of complex, multi-year programs in a dynamic environment. Collaborate with cross-functional teams to manage scope, budget, and timelines while ensuring client satisfaction an...
Reposted 2 days ago
Senior Software Engineer, Behavior Planning
$135K - $160K *
Join a team that's shaping the future of autonomous driving by designing and implementing advanced behavior planning systems. Collaborate with experts to tackle complex challenges in dynamic environme...
1 week ago
Founding Talent Partner, Salesforce Expert Network
$100K - $120K *
Engage with top Salesforce talent to build a robust expert network. Collaborate with delivery teams to match consultants with projects, ensuring optimal fit and timely staffing. Drive community growth...
2 weeks ago
Procurement Initiatives and Compliance Lead
$143K - $196K *
Lead the charge in driving procurement compliance and strategic initiatives, collaborating across functions to optimize processes and ensure adherence to regulations while supporting business goals an...
3 weeks ago
Protective Intelligence and Investigations Lead
$125K - $150K *
Shape the future of protective intelligence by building and owning a comprehensive program that integrates threat assessments, investigations, and operational processes, ensuring security while enabli...
6 days ago
Senior Software Engineer (Python / AI Insurance SaaS)
$200K - $225K *
Drive the design and delivery of innovative AI-driven applications. Oversee the full development lifecycle, ensuring scalability and reliability in multi-tenant enterprise solutions while collaboratin...
Reposted 5 days ago
Substation Engineering: Principal Engineer
$125K - $150K *
Unlock your potential as a senior technical leader in utility substation engineering, driving quality standards and innovative solutions for complex projects while mentoring a growing team and collabo...
3 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.