Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$150K - $180K *
Elevate your career by providing technical leadership on high-impact cloud projects. Collaborate with a distributed team to enhance our cloud platform's efficiency and drive strategic initiatives acro...
1 week ago
Lead Product Manager, AI Platform
$139K - $176K *
Unlock potential by leading the development of a transformative AI platform. Drive product strategy, enhance user experience, and ensure alignment across teams to deliver impactful solutions that empo...
4 weeks ago
$125K - $145K *
Shape government funding strategies by partnering with sector leaders to identify and secure opportunities that align with research priorities, enhancing organizational impact through effective captur...
2 weeks ago
Program Manager, Supply Chain Analytics
$190K - $240K *
Champion the modernization of global supply chain analytics by transforming data into actionable insights, driving AI-assisted workflows, and collaborating across teams to enhance decision-making and...
1 week ago
$110K - $130K *
Deliver impactful clinical study management by leading global trials, ensuring timely, budget-compliant execution while maintaining the highest quality standards and fostering collaboration with cross...
1 week ago
Senior Product Transformation Lead
$120K - $160K *
Drive strategic product transformation by connecting customer needs with engineering insights. Leverage data to design impactful programs, enhance platform adoption, and facilitate cross-functional co...
Yesterday
$150K - $180K *
Lead and architect innovative AI-driven financial solutions, collaborating with elite engineers to design, implement, and optimize cutting-edge tools for global clients in a dynamic, startup environme...
3 weeks ago
$150K - $180K *
Innovate cutting-edge AI financial solutions by architecting and deploying advanced chat interfaces and reporting systems. Collaborate with elite engineers to enhance investment workflows for global c...
3 weeks ago
$150K - $180K *
Elevate software solutions by architecting AI-driven financial tools, collaborating with elite engineers to enhance investment workflows, and ensuring high standards in quality and security within a d...
3 weeks ago
$150K - $180K *
Join our team to design and implement production-grade workflows that enhance software engineering processes while collaborating with customers. Own the entire project lifecycle from discovery through...
Reposted yesterday
$120K - $145K *
Drive your career with impactful Terafina implementation projects, collaborating with cross-functional teams to customize solutions, manage integrations, and support clients through all project phases...
Reposted 1 week ago
Technical Applications Scientist - East Coast
$84K - $95K *
Join a dynamic team to provide technical support for Nanopore sequencing, guiding customers through experimental design, troubleshooting, and data analysis. Collaborate cross-functionally to enhance c...
3 days ago
$110K - $130K *
Elevate project documentation and technical reporting for large-scale mining initiatives. Collaborate across departments to ensure operational readiness and compliance with industry standards while ma...
1 week ago
Program Manager, EPD Operations
$152K - $191K *
Lead operational health initiatives by optimizing processes and driving efficiency within Engineering, Product, and Design teams. Collaborate across functions to enhance productivity and implement dat...
2 weeks ago
Program Manager, EPD Operations
$114K - $143K *
Drive operational excellence as a Program Manager, enhancing EPD processes and collaboration. Leverage data insights to identify trends, improve efficiency, and support cross-functional teams in a dyn...
2 weeks ago
$164K - $226K *
Lead the charge in designing and evolving a robust entity data platform, ensuring accurate and timely data delivery while enhancing system reliability and reducing manual validation through innovative...
4 weeks ago
Sr. Staff Applied AI Engineer, GTM
$180K - $225K *
Lead the charge in transforming AI strategies into impactful solutions for revenue teams, collaborating closely with GTM leaders to drive innovation and measurable outcomes while enhancing engineering...
1 week ago
$94K - $120K *
Lead the charge in delivering impactful IT projects by managing all phases from initiation to closeout. Collaborate with diverse teams to ensure timely and successful project execution while aligning...
2 days ago
$200K - $250K *
Innovate AI solutions by collaborating with business teams to design, build, and launch impactful products. Own the entire product lifecycle, from discovery to production, ensuring measurable improvem...
1 week ago
Senior Operational Strategy Director
$203K - $304K *
Champion innovative operational strategies in clinical research, driving excellence in bid defense meetings and proposal development. Collaborate with cross-functional teams to enhance study execution...
3 weeks ago
$180K - $248K *
Advance our product strategy by leading the integration of data center operations into Prism, enhancing diagnostics and decision-making for operators and executives alike. Collaborate with cross-funct...
Reposted 3 days ago
Enterprise Sales, Commercial Practice
$140K - $160K *
Drive new business development and revenue growth by leveraging professional networks and sales expertise to secure major client engagements and enhance executive relationships within Fortune 500 comp...
Reposted 2 weeks ago
Senior Software Engineer, Search & AI
$95K - $110K *
Discover a dynamic role where you'll enhance customer search experiences and backend systems. Collaborate across teams to deliver intuitive, AI-powered solutions while ensuring performance and reliabi...
2 days ago
Senior Product Designer, Mobile
$110K - $130K *
Unlock potential by designing intuitive AI experiences for diverse construction teams, blending interaction and visual design. You'll create mobile-first solutions for Superintendents and DCOs, ensuri...
Reposted 3 days ago
Senior Regulatory Affairs Associate - Regulatory Intelligence
$95K - $115K *
Drive regulatory intelligence initiatives to ensure compliance and support clinical research. Collaborate with experts to assess regulatory changes, track global guidelines, and enhance impact assessm...
2 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.