Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$210K - $250K *
Lead the charge in driving strategic medical initiatives across projects, providing expert guidance and oversight on clinical trials to ensure successful development of therapies in psychiatry...
Reposted 1 week ago
$127K - $159K *
Drive statistical leadership in oncology clinical development, guiding study design, analysis, and regulatory submissions. Collaborate with cross-functional teams to ensure high-quality deliverables a...
1 week ago
Senior Director, Strategic Partnerships & Business Development (Genomics & Multiomics)
$130K - $170K *
Transform the future of genomics by driving strategic partnerships and large-scale research projects with pharmaceutical and biotech companies. Leverage your extensive network to identify opportunitie...
2 days ago
$120K - $145K *
Unlock potential by leading power systems engineering for transmission protection. Drive compliance, enhance reliability, and guide teams in innovative solutions to shape the future of energy with adv...
3 weeks ago
Account Manager, Life Science, Public Health Labs (East Coast)
$105K - $120K *
Engage with public health labs to enhance customer satisfaction and drive sales. Collaborate with cross-functional teams to execute market strategies and foster relationships with key opinion leaders...
1 week ago
Director, Integrated Marketing
$130K - $160K *
Join a dynamic team to drive integrated marketing strategies that enhance brand visibility and support business growth through innovative campaigns, digital activation, and thought leadership across m...
3 weeks ago
Technical Program Manager, Infrastructure
$130K - $155K *
Transform large-scale GPU cluster builds by leading program delivery, managing vendor dependencies, and ensuring timely execution. Collaborate with teams to streamline processes and enhance infrastruc...
2 days ago
Associate Director/Director, Asset Acquisition
$190K - $250K *
Analyze and evaluate therapeutic opportunities to drive innovation and business development. Collaborate with interdisciplinary teams to assess scientific and commercial viability, ensuring alignment...
1 week ago
$90K - $132K *
Join us to provide analytical support, troubleshoot systems, and enhance operational efficiency. Collaborate with maintenance teams, manage spare parts, and ensure compliance with safety standards whi...
Yesterday
Staff Software Engineer - Performance Advisor
$220K - $240K *
Shape the future of loyalty by leading the technical execution and innovation of AI-powered features in a rapidly evolving product landscape, driving cross-functional initiatives with a focus on archi...
Reposted 3 weeks ago
Scientific Developer for Model Optimization
$110K - $130K *
Innovate cutting-edge solutions in scientific software development, enhancing model performance and optimizing workflows. Collaborate with teams to integrate advanced technologies and improve computat...
1 week ago
Senior Director, Commercial Analytics & Decision Science
$219K - $285K *
Shape and lead a centralized commercial analytics function, transforming complex data into actionable insights. Drive performance measurement, growth identification, and strategic decision-making acro...
2 weeks ago
21GRAMS- Associate Creative Director, Copy
$160K - $180K *
Unlock potential by leading creative engagements across healthcare accounts. Drive innovative campaigns, mentor teams, and manage client relationships while delivering impactful narratives that resona...
1 week ago
Senior Software Engineer, AI Automation
$134K - $199K *
Drive innovation by leading the design and delivery of AI agents and workflows that enhance operational efficiency. Collaborate with cross-functional teams to transform complex challenges into scalabl...
2 weeks ago
Senior Software Engineer, AI Automation
$130K - $195K *
Join a dynamic AI Automation team to design and deliver production-grade AI agents and workflows, enhancing operational efficiency across the organization while solving complex business challenges wit...
2 weeks ago
$120K - $140K *
Build innovative back-end solutions in a multi-tenant SaaS environment. Collaborate with a dynamic team to design, develop, and maintain efficient systems while leveraging AI and best practices for so...
2 days ago
$175K - $200K *
Oversee integrated planning across multiple workstreams, ensuring alignment and timely execution. Collaborate cross-functionally to connect roadmaps with delivery capacity, supporting annual planning...
6 days ago
Member of Technical Staff (Site Reliability Engineer, Cloud Infrastructure)
$130K - $155K *
Join a team that's dedicated to ensuring reliability at scale. You'll manage compute, networking, and storage, driving performance and stability while adapting to rapid changes in production environme...
1 week ago
$65K - $108K *
Unlock potential by providing advanced technical support and engineering expertise to resolve complex production issues. Manage end-to-end case ownership while collaborating with teams to enhance serv...
4 weeks ago
$160K - $200K *
Elevate the future of travel by leading AI-driven hotel booking innovations. Collaborate closely with the CEO to shape product direction, enhance existing platforms, and build a dynamic team focused o...
1 week ago
Principal Engineer, Engineering Core Services
$208K - $244K *
Accelerate progress at a leading multi-product company by owning the architecture of shared services. Drive innovation in customer identity, commerce, and billing platforms while mentoring senior engi...
1 week ago
$116K - $174K *
Elevate regulatory strategies for global product approvals and compliance. Lead negotiations with authorities, manage complex projects, and drive innovative solutions to ensure successful market intro...
4 weeks ago
Senior Gen AI Applications Architect
$126K - $189K *
Accelerate progress at the forefront of AI/ML innovation by designing and deploying advanced generative and agentic AI solutions. Lead cross-functional teams to enhance grid automation and drive effic...
2 weeks ago
Director of US Government Engagement
$210K - $260K *
Advance your career by leading US government engagement initiatives, shaping policy and funding strategies, and building bipartisan relationships to enhance quantum technology adoption and support nat...
3 weeks ago
Lead Product Manager, NetSuite Order-to-Cash
$100K - $140K *
Champion the modernization of Order-to-Cash processes, driving efficiency and accuracy in billing and collections. Collaborate with cross-functional teams to optimize NetSuite ERP, enhancing financial...
4 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.