Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$110K - $130K *
Join a team that's dedicated to shaping regulatory documents and medical communications. Play a key role in supporting product development while collaborating with cross-functional teams to ensure com...
Reposted 6 days ago
$170K - $234K *
Drive the architecture and development of audio signal processing technology, leading complex engineering efforts and ensuring high-quality, reusable DSP components across multiple product lines...
2 weeks ago
Director, Clinical Supply Chain (or Senior)
$210K - $230K *
Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...
1 week ago
Principal Structural Engineer, Global
$170K - $175K *
Champion innovative structural design for mission-critical data centers, focusing on prefabricated and modular construction. Lead technical strategy, establish design standards, and ensure safety and...
4 weeks ago
$175K - $218K *
Join a team that's redefining revenue growth through innovative ML solutions. As a Lead Data Scientist, you'll drive impactful monetization strategies for millions of users, collaborating across teams...
4 weeks ago
$120K - $145K *
Champion quality by designing and leading automated testing strategies for diverse products. Collaborate with engineers to enhance test frameworks, mentor teams, and ensure high standards across platf...
1 week ago
Sr. Clinical Research Associate
$91K - $137K *
Drive your career forward as you manage complex clinical sites, ensuring compliance with protocols and regulations. Collaborate with cross-functional teams while mentoring junior staff to enhance stud...
6 days ago
$144K - $200K *
Shape the future of enterprise technology by leading transformative consulting engagements. Collaborate with C-level executives to drive strategic initiatives in AI, cloud, and analytics, ensuring imp...
1 week ago
$180K - $220K *
Drive strategic initiatives within Medical Affairs, enhancing oncology portfolio engagement and collaboration across teams to achieve medical objectives and support clinical trials...
3 days ago
Senior Manager, Integrated Marketing
$114K - $129K *
Unlock your potential by developing integrated marketing strategies that drive demand and engage customers. Collaborate with cross-functional teams to translate business priorities into actionable cam...
2 days ago
$115K - $130K *
Drive client growth by leveraging data-driven insights to enhance strategic relationships and deliver impactful solutions. Collaborate cross-functionally to achieve measurable outcomes and ensure clie...
3 weeks ago
Senior Engineering Consultant - Equity Due Diligence
$110K - $130K *
Unlock potential by leading complex commercial real estate due diligence projects. Collaborate with multidisciplinary teams to provide technical guidance and client leadership, ensuring high-quality d...
1 week ago
Senior Customer Manager - Performance Monomers
$110K - $130K *
Join a team that's driving innovation and sustainability by managing complex accounts, leading negotiations, and executing strategic sales plans to achieve financial targets and foster long-term custo...
Today
Senior Manager, Medical Information and Medical Capabilities
$130K - $155K *
Elevate your career by joining a dynamic Medical Affairs team, where you'll lead Medical Information initiatives, ensure compliance, and drive strategic insights to support our innovative pipeline in...
4 weeks ago
$95K - $115K *
Unlock potential by leveraging data science to drive informed decision-making through advanced analytics, modeling, and collaboration in a dynamic research environment...
1 week ago
Executive Director, Commercial Strategy
$285K - $335K *
Lead the charge in developing and executing commercial strategies that drive brand growth and enhance decision-making capabilities across a dynamic portfolio, focusing on oncology and market insights...
2 days ago
Knowledge & Research Legal Engineer
$68K - $113K *
Transform legal research by partnering with law firm librarians to implement AI solutions, enhance workflows, and drive adoption. Build relationships, provide strategic guidance, and lead training to...
4 days ago
Senior / Principal Consultant - Lab Informatics & Digital Lab Transformation(Remote)
$90K - $150K *
Transform your career by leading digital lab consulting initiatives, driving strategy, and implementing solutions across manufacturing and quality control laboratories. Engage with stakeholders to opt...
Reposted 1 week ago
Manager, People Analytics & Data Science
$128K - $252K *
Drive the evolution of people analytics by building data pipelines, dashboards, and insights that empower leaders with decision-ready information. Collaborate across teams to enhance data usability an...
3 weeks ago
Associate Director/Director, Clinical Program Management
$135K - $160K *
Advance clinical trial execution by leading cross-functional teams, ensuring timely delivery of innovative therapies. Collaborate with stakeholders to navigate product life cycles from concept to comm...
2 days ago
Pharmaceutical/Biotechnology Segment Leader
$119K - $190K *
Champion ABB's growth in the Pharmaceutical & Biotechnology sector by developing strategies, building executive relationships, and identifying market opportunities to drive sales and enhance customer...
2 weeks ago
Senior Engineer, Data Engineering
$144K - $165K *
Unlock potential by owning data architecture and reliability across domains. Collaborate with an AI-first team to design robust data pipelines, enhance analytics, and drive impactful solutions in a dy...
1 week ago
Principal Regulatory Affairs Specialist
$109K - $185K *
Empower innovation in diabetes care by navigating regulatory pathways for cutting-edge medical devices, collaborating globally to ensure compliance and product success while impacting lives positively...
Reposted 3 weeks ago
$110K - $130K *
Join a team that's driving high-impact commercial data center projects from inception to completion, ensuring alignment with strategic goals, timelines, and budgets while fostering collaboration among...
2 weeks ago
$110K - $130K *
Lead the charge in managing high-impact commercial data center projects, ensuring alignment with client goals, timelines, and budgets while fostering collaboration among stakeholders and driving opera...
2 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.