Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Clinical Trial Manager/Senior Clinical Trial Manager
$110K - $200K *
Transform clinical research by leading operational oversight of studies, ensuring compliance with protocols and regulations. Collaborate with teams to drive site feasibility, manage budgets, and enhan...
1 week ago
Clinical Trial Manager/Senior Clinical Trial Manager
$110K - $200K *
Join a team that's dedicated to advancing clinical research by leading operational aspects of trials, ensuring compliance with protocols and regulations, and fostering collaboration among stakeholders...
1 week ago
$80K - $95K *
Join a team that's dedicated to transforming data into actionable insights. As a Senior Analyst, you'll tackle complex challenges, support strategic initiatives, and collaborate with experts to enhanc...
2 days ago
Senior Technical Program Manager
$128K - $214K *
Empower cross-functional teams to deliver complex technical programs, ensuring alignment with business goals. Lead planning, execution, and stakeholder communication while fostering a collaborative en...
2 weeks ago
Senior Strategy & Decision Analyst
$120K - $145K *
Help us ensure high-quality decision-making by collaborating with leaders to frame strategies and analyze options, driving impactful decisions that align with organizational goals and values while fos...
1 week ago
Executive Director, Pharmaceutical Development, Small Molecule
$247K - $337K *
Lead CMC Pharmaceutical Development for small molecules, driving innovation and strategy from early development to commercialization while ensuring regulatory compliance and operational excellence...
Reposted 6 days ago
$250K - $290K *
Accelerate progress at our East Region by leading strategic growth initiatives, mentoring managers, and driving profitable operations within a high-performing team dedicated to environmental consultin...
Reposted 6 days ago
$135K - $160K *
Transform product security by leading strategy, conducting threat modeling, and collaborating across teams to ensure secure design and compliance. Drive innovation in security practices while mentorin...
3 weeks ago
Senior Project Manager, Scrum Master
$130K - $140K *
Lead the charge in delivering enterprise data platform initiatives, managing Agile processes, and ensuring effective collaboration across teams. Drive project execution from discovery to deployment wh...
Yesterday
Senior Director, Portfolio Strategy, Analytics & Enablement, Cardiometabolic Research
$160K - $235K *
Join a dynamic team to shape and implement cardiometabolic research strategies, driving high-impact initiatives that foster growth and operational excellence while collaborating across therapeutic are...
Yesterday
$104K - $131K *
Transform oncology marketing operations by leading systems, processes, and planning. Collaborate with cross-functional teams to ensure compliance and efficiency while managing a dedicated team and opt...
3 days ago
Physical Scientist for High-Resolution Regional Modeling for Atmospheric Rivers
$95K - $115K *
Unlock potential by conducting high-resolution modeling for atmospheric rivers, enhancing predictive capabilities within the Unified Forecast System, and collaborating on innovative parameterization m...
4 weeks ago
Senior Director, Regulatory CMC (remote)
$175K - $283K *
Champion regulatory excellence by leading CMC strategies for small molecule programs, ensuring compliance and driving successful submissions from early development through commercialization in a dynam...
1 week ago
$110K - $166K *
Lead the charge in managing site contract negotiations and agreements, ensuring alignment with clinical study timelines. Collaborate with cross-functional teams to enhance contract processes and mento...
Reposted 6 days ago
$162K - $190K *
Lead the charge in developing scalable analytics and KPI frameworks, ensuring trusted metrics drive impactful business decisions. Collaborate cross-functionally to standardize measurement and enhance...
2 weeks ago
Senior AI Transformation Analyst
$90K - $110K *
Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...
Reposted 2 days ago
Senior Manager, Regulatory Affairs Labeling
$150K - $189K *
Transform global labeling strategies into actionable regional plans, ensuring compliance and quality. Oversee document preparation, vendor management, and cross-functional approvals to deliver timely...
2 days ago
$113K - $125K *
Drive product strategy and outcomes in a senior role, focusing on educational equity and data-driven impact. Collaborate with cross-functional teams to shape product direction, prioritize initiatives...
1 week ago
Project Manager, Congress Planning
$110K - $148K *
Transform global congress planning by leading cross-functional teams, managing timelines, and ensuring quality execution. Drive strategic alignment and operational excellence to deliver impactful cong...
Today
Program Manager, Client Services, Clinical Trial Support
$88K - $105K *
Lead the charge in managing client relationships and program performance, ensuring timely delivery of medications. Oversee budgets, facilitate communication between stakeholders, and drive successful...
2 weeks ago
Senior Principal, Business Management
$135K - $160K *
Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...
Reposted 4 days ago
Senior Structural Engineer -- S&L Consulting
$118K - $180K *
Unlock potential by leading structural engineering reviews for renewable energy projects. Collaborate with multi-discipline teams to optimize design, support financing, and deliver actionable insights...
1 week ago
$110K - $130K *
Drive efficient order management and logistics operations, ensuring compliance with pharmaceutical regulations while collaborating with internal teams and 3PL partners to optimize product flow and per...
Reposted today
Product Manager, National Center for Clinical Trials (NCCT)
$122K - $183K *
Transform how we operate by leading technology-driven initiatives that enhance business capabilities. Collaborate with cross-functional teams to define product strategies and drive measurable outcomes...
6 days ago
$110K - $130K *
Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...
Reposted 2 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.