Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$110K - $130K *
Lead the charge in ensuring compliance of promotional materials with Canadian regulations. Collaborate with cross-functional teams to review and approve content, providing regulatory insights and prac...
Today
$95K - $115K *
Drive revenue growth and customer retention by executing strategic account plans for diagnostic solutions in the Immunodiagnostics Division, fostering partnerships with key stakeholders in healthcare...
Reposted 1 week ago
Senior Sales Development Representative
$128K - $191K *
Join a team that's driving growth in the CBRNe Safety & Security sector. You'll identify new business opportunities, develop strategies, and manage the sales cycle while collaborating with cross-funct...
Yesterday
$110K *
Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...
Reposted 1 week ago
Regulatory Affairs Consultant - CMC US/EU - Mature Biological products
$110K - $130K *
Transform global CMC regulatory strategies for biologics and vaccines, ensuring compliance and quality in submissions. Collaborate with cross-functional teams to influence outcomes and enhance patient...
2 weeks ago
Director, Organizational Effectiveness & Culture Transformation
$150K - $180K *
Lead the charge in transforming organizational culture and effectiveness by partnering with senior leaders to embed impactful behaviors and practices. Drive measurable change and foster collaboration...
3 days ago
Logistics & Demand Planning Director
$150K - $170K *
Join us to lead demand planning and logistics optimization in Life Sciences. Drive data-driven decisions, enhance capacity strategies, and ensure compliance while collaborating across teams to improve...
1 week ago
Senior Principal Solution Architect, Security and Risk
$173K - $303K *
Join a team that's redefining security solutions by leveraging deep expertise to drive customer success. Collaborate with stakeholders, lead engagements, and innovate to enhance risk management practi...
3 days ago
Senior Principal Solution Architect, Security and Risk
$150K - $262K *
Unlock potential by leading the implementation of ServiceNow's Security and Risk solutions. Collaborate with customers and partners to drive business outcomes, provide architectural guidance, and ment...
3 days ago
Senior Principal Solution Architect, Security and Risk
$173K - $303K *
Transform customer outcomes by architecting innovative Security and Risk solutions. Leverage deep expertise to guide implementations, engage with senior leadership, and drive best practices while ment...
3 days ago
Senior Principal Solution Architect, Security and Risk
$173K - $303K *
Unlock potential by leading the implementation of ServiceNow's Security and Risk solutions. Collaborate with customers and partners to drive business outcomes, provide architectural guidance, and ment...
2 weeks ago
$150K - $160K *
Champion cloud and application security by enhancing AWS practices, collaborating with cross-functional teams, and driving continuous improvement to ensure secure and compliant environments...
Reposted 6 days ago
$160K - $180K *
Lead the development of AI governance solutions, transforming research into market-ready products. Collaborate with cross-functional teams to ensure customer-focused outcomes and drive product success...
2 days ago
$128K - $178K *
Lead the charge in shaping the future of destination marketing through data-driven insights and innovative product strategies. Collaborate with cross-functional teams to enhance customer experiences a...
4 weeks ago
Principal Backend Engineer, Enterpise Platform
$255K - $295K *
Lead the technical direction for foundational services, guiding architecture and execution across teams to enhance platform capabilities for customer and partner experiences. Mentor engineers and infl...
2 days ago
Microelectronics Ultrapure Water (UPW) Senior Process Engineer
$110K - $130K *
Drive innovative ultrapure water treatment solutions as a key technical leader, collaborating with customers to optimize system design and operation while ensuring compliance with industry standards a...
1 week ago
Microelectronics Ultrapure Water (UPW) Senior Process Engineer
$110K - $130K *
Join a team that's redefining ultrapure water treatment solutions. As a key technical leader, you'll leverage your expertise to design and optimize systems for the microelectronics industry, ensuring...
1 week ago
Principal Product Marketing Manager (AI Gateway)
$145K - $175K *
Elevate your career by leading product marketing for AI governance solutions. Drive impactful narratives, engage with analysts, and create high-quality content to enhance visibility and credibility in...
3 weeks ago
Principal Engineer - Networking
$171K - $268K *
Discover your potential as a Principal Engineer/System Architect, driving innovative networking solutions and leading a collaborative team to define complex architecture while engaging with partners t...
Reposted 1 week ago
Senior Data Scientist - Growth
$200K - $250K *
Drive your career with a strategic role that shapes customer growth through data insights. Collaborate with cross-functional teams to optimize the growth funnel, influence product direction, and enhan...
3 weeks ago
$225K - $265K *
Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...
1 week ago
Bioscience Account Manager, Illinois
$70K - $105K *
Drive sales growth in a newly established territory by building customer relationships, identifying opportunities, and collaborating with internal teams to deliver innovative solutions in life science...
Reposted 1 week ago
Senior Director of Engineering
$261K - $308K *
Transform Women's Health engineering by leading a high-impact team to deliver innovative software solutions. Collaborate across functions to shape strategy and drive organizational excellence while en...
1 week ago
$95K - $115K *
Elevate your career by joining our dynamic sales team to drive revenue growth and foster customer relationships. You'll implement strategic sales plans and collaborate with cross-functional teams to d...
4 weeks ago
Senior Consultant, Safety and Reliability
$126K - $153K *
Lead the charge in transforming healthcare safety cultures by applying High Reliability Organization principles, enhancing patient trust, and driving data-driven process improvements across clinical s...
2 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.