Principal Scientist Jobs

Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.

What Does a Principal Scientist Do?

Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.

Skills and Qualifications

Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.

Principal Scientist Salary and Career Outlook

Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.

Find Principal Scientist Jobs on Ladders

Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
More
1
caret down

$110K - $130K *

Lead the charge in ensuring compliance of promotional materials with Canadian regulations. Collaborate with cross-functional teams to review and approve content, providing regulatory insights and prac...

Ontario, CARemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Drive revenue growth and customer retention by executing strategic account plans for diagnostic solutions in the Immunodiagnostics Division, fostering partnerships with key stakeholders in healthcare...

Ohio, USRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$128K - $191K *

Join a team that's driving growth in the CBRNe Safety & Security sector. You'll identify new business opportunities, develop strategies, and manage the sales cycle while collaborating with cross-funct...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K *

Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform global CMC regulatory strategies for biologics and vaccines, ensuring compliance and quality in submissions. Collaborate with cross-functional teams to influence outcomes and enhance patient...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in transforming organizational culture and effectiveness by partnering with senior leaders to embed impactful behaviors and practices. Drive measurable change and foster collaboration...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $170K *

Join us to lead demand planning and logistics optimization in Life Sciences. Drive data-driven decisions, enhance capacity strategies, and ensure compliance while collaborating across teams to improve...

Boston, MARemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$173K - $303K *

Join a team that's redefining security solutions by leveraging deep expertise to drive customer success. Collaborate with stakeholders, lead engagements, and innovate to enhance risk management practi...

Chicago, ILRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $262K *

Unlock potential by leading the implementation of ServiceNow's Security and Risk solutions. Collaborate with customers and partners to drive business outcomes, provide architectural guidance, and ment...

Atlanta, GARemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$173K - $303K *

Transform customer outcomes by architecting innovative Security and Risk solutions. Leverage deep expertise to guide implementations, engage with senior leadership, and drive best practices while ment...

Dallas, TXRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$173K - $303K *

Unlock potential by leading the implementation of ServiceNow's Security and Risk solutions. Collaborate with customers and partners to drive business outcomes, provide architectural guidance, and ment...

San Diego, CARemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $160K *

Champion cloud and application security by enhancing AWS practices, collaborating with cross-functional teams, and driving continuous improvement to ensure secure and compliant environments...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $180K *

Lead the development of AI governance solutions, transforming research into market-ready products. Collaborate with cross-functional teams to ensure customer-focused outcomes and drive product success...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$128K - $178K *

Lead the charge in shaping the future of destination marketing through data-driven insights and innovative product strategies. Collaborate with cross-functional teams to enhance customer experiences a...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$255K - $295K *

Lead the technical direction for foundational services, guiding architecture and execution across teams to enhance platform capabilities for customer and partner experiences. Mentor engineers and infl...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive innovative ultrapure water treatment solutions as a key technical leader, collaborating with customers to optimize system design and operation while ensuring compliance with industry standards a...

Houston, TXRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $130K *

Join a team that's redefining ultrapure water treatment solutions. As a key technical leader, you'll leverage your expertise to design and optimize systems for the microelectronics industry, ensuring...

Boise, IDRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$145K - $175K *

Elevate your career by leading product marketing for AI governance solutions. Drive impactful narratives, engage with analysts, and create high-quality content to enhance visibility and credibility in...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$171K - $268K *

Discover your potential as a Principal Engineer/System Architect, driving innovative networking solutions and leading a collaborative team to define complex architecture while engaging with partners t...

New Hampshire, USRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$200K - $250K *

Drive your career with a strategic role that shapes customer growth through data insights. Collaborate with cross-functional teams to optimize the growth funnel, influence product direction, and enhan...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$225K - $265K *

Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$70K - $105K *

Drive sales growth in a newly established territory by building customer relationships, identifying opportunities, and collaborating with internal teams to deliver innovative solutions in life science...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$261K - $308K *

Transform Women's Health engineering by leading a high-impact team to deliver innovative software solutions. Collaborate across functions to shape strategy and drive organizational excellence while en...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$95K - $115K *

Elevate your career by joining our dynamic sales team to drive revenue growth and foster customer relationships. You'll implement strategic sales plans and collaborate with cross-functional teams to d...

North Carolina, USRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$126K - $153K *

Lead the charge in transforming healthcare safety cultures by applying High Reliability Organization principles, enhancing patient trust, and driving data-driven process improvements across clinical s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What does a Principal Scientist do?question toggle

    A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.

  • What qualifications are commonly required for Principal Scientist jobs?question toggle

    Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.

  • How much do Principal Scientists earn?question toggle

    Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.

  • Where do Principal Scientists work?question toggle

    Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.

  • How can I find Principal Scientist jobs on Ladders?question toggle

    Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.