Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Senior Application Engineer - Ultrapure Water & Microelectronics
$109K - $154K *
Lead the design and implementation of innovative Ultra Pure Water solutions, managing client relationships and project lifecycles. Collaborate with cross-functional teams to deliver tailored engineeri...
1 week ago
Senior Application Engineer - Ultrapure Water & Microelectronics
$109K - $154K *
Shape the future of water treatment by leading innovative solutions in ultrapure water systems. Collaborate with global teams to manage proposals and engage clients, ensuring technical excellence and...
1 week ago
$83K - $104K *
Lead the charge in managing complex client programs, driving operational excellence and strategic direction while fostering strong stakeholder relationships and ensuring exceptional service delivery...
1 week ago
$131K - $205K *
Engage in the design and evaluation of electric power generation projects. Provide technical support and owner’s engineering services, focusing on thermal power systems. Collaborate on project develop...
1 month ago
Principal Engineer, Solutions Architecture - Networking
$142K - $203K *
Design and optimize AI-ready networking infrastructures to support high-performance computing and data-intensive workloads. Collaborate with customers to assess, plan, and implement scalable solutions...
Reposted 1 week ago
Senior Director, Field Operations
$229K - $330K *
Join us to redefine revenue operations by leading a dynamic team that transforms GTM strategies into actionable insights, ensuring scalable success across diverse market segments and driving AI-enhanc...
2 days ago
Principal Offensive Security Engineer
$183K - $200K *
Shape the future of offensive security by leading advanced penetration testing, red-team engagements, and AI-assisted workflows. Collaborate with cross-functional teams to enhance security measures an...
2 days ago
Environmental Impact Assessment Professional
$160K - $190K *
Shape environmental impact assessment strategies for major projects. Cultivate stakeholder relationships and lead multidisciplinary teams while driving compliance with regulatory standards to ensure s...
Reposted 6 days ago
Head of Global Environment, Health, & Safety (EHS)
$150K - $180K *
Transform global safety standards by leading the Environment, Health & Safety program. Drive strategic initiatives, foster a culture of compliance, and enhance organizational capability across diverse...
2 weeks ago
Senior Engagement Principal | Software Delivery
$212K - $222K *
Champion client success as you lead Aera solution deployments, building trusted relationships with executives to drive value and Decision Intelligence roadmaps while managing project delivery and fost...
Reposted 5 days ago
$144K - $173K *
Shape the future of pharmaceutical media by leading client strategy and integrated media delivery. Drive audience engagement, manage high-impact relationships, and leverage data insights to achieve me...
3 weeks ago
Advanced Specialist, Technology Solutions
$110K - $120K *
Explore a pivotal role in leading complex analysis across systems, driving alignment among stakeholders, and enhancing technology solutions. Collaborate with diverse teams to translate business needs...
Reposted 6 days ago
Senior Strategic Solutions & Story Architect
$117K - $176K *
Empower your career by leading cross-functional teams to craft compelling narratives that drive strategic pursuits. Utilize your expertise in clinical development and storytelling to enhance customer...
2 days ago
Senior Manager, Workday Absence & Time Tracking
$150K - $189K *
Elevate organizational efficiency by leading Workday Absence and Time Tracking solutions. Collaborate cross-functionally to optimize processes, ensuring compliance and enhancing user experience as the...
4 weeks ago
Senior Supervising Process Engineer
$125K - $225K *
Drive innovation and strategic leadership in wastewater treatment and reuse projects, guiding multidisciplinary teams to deliver sustainable, cutting-edge engineering solutions while fostering client...
Reposted 3 days ago
$133K - $200K *
Accelerate clinical data management processes by leading data entry, ensuring quality, and overseeing database development for clinical trials. Collaborate with cross-functional teams to meet project...
2 days ago
$133K - $200K *
Drive excellence in clinical data management by overseeing data processes, ensuring quality, and leading cross-functional teams to deliver timely and accurate results throughout the clinical trial lif...
2 days ago
Sr. Director - Life Sciences Commercial
$166K - $200K *
Transform your career by driving revenue growth and client engagement in the life sciences sector. Lead strategic initiatives, foster key relationships, and deliver innovative solutions that enhance c...
2 days ago
Sr. Director - Life Sciences Commercial
$170K - $200K *
Elevate your career by driving revenue growth and client engagement in the life sciences sector. Lead strategic initiatives, foster key relationships, and deliver tailored solutions that revolutionize...
2 days ago
Sr. Director - Life Sciences Commercial
$170K - $200K *
Join a team that's revolutionizing healthcare by driving growth in life sciences. You'll lead strategic initiatives, engage key clients, and ensure exceptional customer experiences while achieving amb...
2 days ago
Sr. Director - Life Sciences Commercial
$170K - $200K *
Lead the charge in driving revenue growth and client engagement within the life sciences sector. Utilize consultative sales strategies to expand key accounts and deliver exceptional customer experienc...
2 days ago
Sr. Director - Life Sciences Commercial
$166K - $200K *
Grow your career with a strategic role driving revenue and client engagement in life sciences. Lead consultative sales, manage key accounts, and collaborate across teams to deliver innovative healthca...
3 days ago
Sr. Director - Life Sciences Commercial
$166K - $200K *
Transform the healthcare landscape by driving revenue growth and client engagement in life sciences. Lead strategic initiatives, manage key accounts, and collaborate across teams to deliver innovative...
3 days ago
Sr. Director - Life Sciences Commercial
$166K - $200K *
Unlock potential by leading strategic growth initiatives in life sciences. Drive revenue expansion and client engagement through consultative sales, while collaborating with cross-functional teams to...
3 days ago
$110K - $130K *
Lead the charge in ensuring compliance of promotional materials with Canadian regulations. Collaborate with cross-functional teams to review and approve content, providing regulatory insights and prac...
Today
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.