Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Staff Technical Program Manager, Enterprise AI
$168K - $231K *
Lead enterprise-wide AI programs, driving operational frameworks and cross-functional collaboration to enhance efficiency and deliver impactful results across the organization...
6 days ago
Director/Sr. Director, Patient Support Programs
$150K - $180K *
Join a team that's dedicated to enhancing patient access through strategic design and management of support programs. Oversee vendor relationships and ensure compliance while driving initiatives that...
4 weeks ago
Sr Director Analyst, Data Management Platforms
$172K - $202K *
Elevate your career by leading innovative insights and strategies for clients. As a Senior Director, you'll leverage your expertise to drive impactful research, engage with executives, and mentor team...
3 weeks ago
Director of Probes Field Service
$183K - $240K *
Lead a global field service organization, driving strategy and operational excellence to enhance customer satisfaction and service delivery for Probe Card products across multiple regions...
1 week ago
Senior Product Manager, Analytics & Insights
$115K - $125K *
Drive the vision and strategy for analytics products, enhancing client insights and program value. Collaborate across teams to deliver AI-enabled solutions, ensuring seamless integration and measurabl...
1 week ago
$105K - $127K *
Champion the management of SR&ED programs, ensuring compliance and maximizing tax credits. Collaborate with cross-functional teams to streamline processes, support audits, and drive financial reportin...
Reposted today
Global Program Manager, Customer Experience Center
$100K - $150K *
Unlock your potential by leading the operational backbone of a new Customer Experience Center. Drive launch readiness, manage vendor relationships, and ensure seamless program execution to deliver exc...
1 week ago
Senior Software Engineer II - Agentic SDLC
$170K - $185K *
Champion innovative software solutions by leading complex projects, mentoring engineers, and driving technical excellence across teams. Collaborate on strategic initiatives to enhance reliability and...
2 weeks ago
Senior DoD Biomanufacturing Project Manager - Telework
$110K - $130K *
Unlock your potential by managing complex DoD biomanufacturing projects. Collaborate with diverse stakeholders, oversee performance metrics, and develop impactful briefings for leadership in a dynamic...
1 week ago
$120K - $145K *
Lead the charge in transforming data analytics for critical enterprise systems. Drive innovative solutions, manage complex data architectures, and collaborate with diverse teams to enhance data-driven...
1 week ago
$120K - $140K *
Help us lead HR integration for M&A projects, managing due diligence to execution. Collaborate with HR teams to mitigate risks, enhance strategies, and ensure smooth transitions for acquired employees...
Yesterday
$88K - $105K *
Transform the landscape of biostatistics by leading project teams, ensuring compliance, and mentoring junior statisticians while delivering high-quality statistical analyses and documentation...
Reposted today
Executive Director, Evidence Generation and Scientific Communications
$175K - $210K *
Lead evidence generation and scientific communications to support innovative gene therapy initiatives. Collaborate with cross-functional teams to identify evidence gaps and execute strategic plans, en...
3 weeks ago
Principal Software Architect (Graph Architect)
$150K - $180K *
Lead the architectural vision for scalable Identity Resolution platforms, driving innovation in enterprise applications and data processing. Collaborate with engineering teams to ensure robust, high-p...
3 weeks ago
VPP - Lead Field Project Engineer
$100K - $120K *
Take ownership of critical VPP projects; manage field operations, partner support, and technical training while leading a team of engineers to ensure top-tier service and product quality within the re...
Reposted 3 weeks ago
ED/VP - Medical Science & Strategy - Oncology(Mandarin Proficiency)
$200K - $400K *
Unlock potential by driving strategic outcomes in Oncology, leveraging extensive expertise to support proposals, engage clients, and mentor teams, ensuring high-quality input for clinical research suc...
Reposted 2 weeks ago
$215K - $269K *
Transform your career by architecting scalable systems in a dynamic engineering environment. As a technical leader, you will guide innovative solutions across multiple teams, ensuring high-performance...
Reposted 3 weeks ago
Project Manager- CARDIOVASCULAR (US/CANADA)
$112K - $222K *
Shape your career by leading clinical project management for global trials. Drive cross-functional collaboration, ensure compliance, and meet project deliverables while fostering effective teamwork an...
Reposted 2 weeks ago
$95K - $115K *
Lead the charge in managing client projects, ensuring high-quality delivery on time and within budget while fostering excellent customer service and collaboration across teams...
1 week ago
Senior Manager, Precision Medicine - Clinical Diagnostics
$150K - $245K *
Drive the execution of companion diagnostics strategy, managing cross-functional teams and partnerships to ensure successful assay development and regulatory compliance, ultimately enhancing patient o...
3 weeks ago
Market Research & Analytics Senior Manager
$162K - $203K *
Drive impactful market research initiatives by collaborating with cross-functional teams to translate business needs into actionable insights, ensuring high-quality execution and strategic decision-ma...
2 days ago
$150K - $180K *
Contribute to the design and execution of clinical studies, ensuring data integrity and quality. Collaborate cross-functionally to drive study activities and support regulatory efforts, while enhancin...
3 weeks ago
Manager, Clinical Data Management Study Lead
$114K - $187K *
Optimize clinical data management processes by leading teams and ensuring compliance with standards. Collaborate with stakeholders to enhance data quality and streamline operations across multiple com...
1 week ago
Senior Specialist, Technical Evaluations & Proposals
$80K - $117K *
Elevate proposal development by collaborating with global teams to create high-quality, tailored proposals for Biologics and Drug Product offerings, ensuring alignment with customer needs and driving...
3 weeks ago
Sr Account Director, Business Development (Biotech CDSD) -US -West Coast Region
$128K - $190K *
Shape the future of biotech by driving strategic sales and fostering key client relationships. Leverage your expertise to maximize revenue growth and enhance client satisfaction in a dynamic, fast-pac...
1 month ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.