Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$130K - $195K *
Accelerate advertiser impact measurement by leading incrementality studies and analytics. Collaborate cross-functionally to refine methodologies and translate insights into actionable strategies for c...
2 weeks ago
$190K - $240K *
Transform the Human Data Trial lifecycle by leading product vision and execution. Collaborate with cross-functional teams to deliver innovative solutions, mentor junior members, and drive impactful da...
2 weeks ago
$95K - $115K *
Empower growth by driving sales of lab supplies and diagnostics. Build strong customer relationships, develop strategic sales plans, and ensure market penetration while achieving sales forecasts in a...
3 weeks ago
$126K - $160K *
Drive impactful software solutions by collaborating with sales teams, leading demos, and managing technical inquiries. Leverage your expertise to enhance customer experiences and support enterprise tr...
2 weeks ago
Director, Business Improvement
$150K - $180K *
Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...
2 weeks ago
Vice President Research & Development
$120K - $140K *
Empower the R&D organization by leading technology strategy, engineering execution, and team development across a diverse healthcare software portfolio, ensuring alignment with market needs and operat...
3 weeks ago
$145K - $180K *
Transform infrastructure operations by leading technical strategy and architecture. Collaborate with executives and teams to design secure, scalable solutions across data centers and cloud environment...
3 days ago
Senior Director, Product Management, Digital AI
$223K - $293K *
Transform the future of R&D by leading digital product strategy and execution, enhancing study budget management and resource forecasting through innovative technology solutions and cross-functional c...
Today
Senior AI Engineer (CCC Auto / Agentic)
$180K - $225K *
Elevate the future of AI systems by architecting LLM-powered workflows that enhance customer interactions, ensuring security and performance while guiding teams through complex challenges and deliveri...
Today
Senior Manager, Insights, Amazon Focus
$105K - $125K *
Join as a hands-on analytics specialist, leveraging Amazon data to drive insights and support decision-making for clients. Collaborate with teams to optimize performance and enhance reporting across v...
2 days ago
Research Scientist - Personalization
$133K - $190K *
Innovate in machine learning and AI by conducting research on large-scale models, developing methodologies, and collaborating with teams to enhance personalization systems and user experiences...
2 weeks ago
$105K - $130K *
Empower your career by leading hydrogeology and environmental projects. Collaborate with multidisciplinary teams to tackle complex groundwater challenges, ensuring technical excellence and client sati...
1 month ago
Senior Director, Delivery Excellence
$207K - $277K *
Lead the charge in enhancing global ERP delivery excellence, driving governance, quality, and continuous improvement across teams. Foster collaboration and optimize resource utilization to ensure pred...
4 weeks ago
Regulatory Strategy Senior Associate
$95K - $115K *
Champion regulatory strategy initiatives to advance patient treatments. Collaborate with cross-functional teams to develop regulatory pathways, support agency engagement, and ensure compliance, all wh...
3 weeks ago
Associate Director, Drug Product, Pulmovant
$130K - $160K *
Lead the technical direction for inhaled dry powder products, ensuring product performance and manufacturability while collaborating with cross-functional teams to navigate development and regulatory...
3 weeks ago
$120K - $145K *
Lead the charge in advancing AI applications in healthcare by developing intelligent agents that uncover financial opportunities within complex datasets, transforming manual analyses into scalable wor...
2 days ago
Head of AI & Business Transformation
$150K - $180K *
Transform your career by leading AI initiatives that drive business growth and operational efficiency. Collaborate across functions to embed AI into Rho's core operations, shaping a future where AI en...
2 weeks ago
Associate Director, Business Improvement
$130K - $160K *
Reimagine business improvement strategies as a senior contributor, leading high-impact initiatives across functions. Drive alignment, governance, and measurable outcomes while influencing stakeholders...
3 weeks ago
Field Application Scientist II, Cell Therapy
$67K - $101K *
Join a dynamic team to provide scientific support and training for cell therapy solutions. Build relationships with customers, optimize workflows, and collaborate across teams to drive technology adop...
1 week ago
Sr. Solutions Sales Manager, Research & Analytics
$110K - $138K *
Optimize sales strategies and drive growth in the US Academic market by partnering with teams to deliver innovative research solutions, enhance customer relationships, and achieve sales targets while...
4 weeks ago
Principal Customer Success Executive - Manufacturing Vertical
$162K - $283K *
Optimize customer success by driving growth and retention for high-value manufacturing accounts. Engage with C-suite executives to co-develop digital transformation strategies, ensuring measurable out...
1 week ago
Senior Financial Analyst - Strategic Finance
$109K - $173K *
Elevate your career by partnering with us to enhance financial forecasting and reporting processes. Leverage your analytical skills to improve business intelligence systems and drive key performance i...
Reposted 1 week ago
$155K - $165K *
Join a team that's redefining enterprise architecture to enhance logistics and installation management. Leverage your expertise to drive compliance and modernization initiatives while collaborating wi...
1 month ago
$130K - $160K *
Join a team that's driving innovative launch campaigns, managing complex schedules, and enhancing internal processes. This role requires a proactive leader to oversee launch operations and foster rela...
1 month ago
Product Manager (CMC expertise)
$100K - $120K *
Drive product strategy by leveraging CMC expertise to translate customer needs into actionable requirements, collaborating with cross-functional teams to deliver user-focused solutions in an agile env...
2 days ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.