Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$85K - $110K *
Unlock potential by driving payer policy strategies and relationships to enhance reimbursement for genetic testing. Collaborate with internal teams and external stakeholders to navigate complex health...
Yesterday
$110K - $120K *
Lead the charge in quality engineering for critical assessment platforms, driving testing excellence and automation maturity. Collaborate with cross-functional teams to ensure reliability and scalabil...
Reposted 5 days ago
Clinical Lead - Senior Site Activation Lead
$116K *
Drive impactful site activation strategies, collaborating with cross-functional teams to ensure timely delivery of clinical projects while enhancing communication and mitigating risks throughout the p...
2 weeks ago
Senior Director, Regulatory CMC
$220K - $275K *
Elevate your career by leading global CMC regulatory strategies for biologics. Collaborate with cross-functional teams, ensure compliance, and drive successful product development while mentoring a hi...
Reposted 4 weeks ago
Principal Consultant - SAP Analytics Solution Lead/Architect
$135K - $160K *
Lead the SAP Analytics strategy and implementation, driving innovation in analytics solutions. Collaborate with stakeholders to deliver insights and manage teams, ensuring successful deployment of SAP...
4 weeks ago
Principal Consultant - SAP Analytics Solution Lead/Architect
$135K - $160K *
Drive SAP Analytics strategy and implementation, leading teams in deploying solutions across SAP Analytics Cloud, BW, and S/4HANA. Collaborate with stakeholders to deliver insights and manage analytic...
3 weeks ago
Director, Clinical Pharmacology
$189K - $246K *
Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...
1 week ago
Sr Director Analyst, Direct Procurement
$172K - $202K *
Unlock innovative insights and strategies in procurement and supply chain leadership. Collaborate with executives to drive actionable solutions, analyze market trends, and enhance client engagement th...
1 month ago
$175K - $210K *
Lead the charge in shaping post-quantum security solutions. Drive partnerships, develop the semiconductor ecosystem, and empower the commercial team with technical insights to create demand and establ...
3 days ago
Senior Product Manager, Consumer
$120K - $145K *
Empower consumer experiences by leading product strategy and execution for innovative genomics solutions. Collaborate with cross-functional teams to enhance user satisfaction and drive adoption throug...
2 weeks ago
Manager of Bioinformatics (Oncology Product Development)
$140K - $175K *
Lead the charge in advancing oncology diagnostics by managing a team of bioinformaticians and data scientists, driving product development, and ensuring high-quality analysis and validation of ctDNA-b...
1 week ago
Staff Decision Scientist, Advanced Analytics
$130K - $242K *
Lead advanced analytics initiatives to enhance MAU insights, driving growth through experimentation and causal inference. Collaborate across teams to establish standards and leverage AI for scalable s...
1 week ago
Senior Project Manager - CNS (North America)
$128K - $254K *
Drive the successful delivery of Phase I-IV clinical trials by leading cross-functional teams, managing project timelines, budgets, and quality standards while fostering strong client relationships an...
Reposted 2 weeks ago
Director Global Safety- Global Periodic Aggregate Safety Reports
$191K - $258K *
Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...
1 week ago
Senior Technical Program Manager
$123K - $217K *
Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...
Reposted 2 days ago
Associate Director, Clinical Science
$180K - $240K *
Lead scientific strategy for clinical development of BHB-1893, collaborating with cross-functional teams to ensure data integrity and regulatory compliance. Drive protocol design, data analysis, and e...
3 weeks ago
$95K - $115K *
Lead the charge in optimizing operational activities within the DHMS program, ensuring compliance and driving continuous improvement. Collaborate with stakeholders to implement effective strategies an...
1 week ago
Regional Insights and Engagement Director, PDAC, Southeast
$201K - $251K *
Engage with Key Opinion Leaders to drive strategic marketing initiatives, leveraging clinical expertise to influence oncologists and enhance brand strategy. Collaborate cross-functionally to execute i...
6 days ago
VP, Industrial Market Sector Leader - Environment
$175K - $210K *
Lead the charge in driving growth within the industrial market sector, leveraging client relationships and market intelligence to enhance profitability and pipeline strength across environmental servi...
2 weeks ago
Senior Bioinformatics & Genomics Data System Engineer
$113K - $142K *
Elevate your career by joining our dynamic team to design, develop, and optimize bioinformatics software tools and systems, ensuring robust functionality and compliance in a fast-paced, innovative env...
1 week ago
Principal Engineer, Mechanical Innovation
$130K - $155K *
Engineer innovative mechanical solutions by translating architectural concepts into practical designs. Collaborate across engineering disciplines while leading HVAC standards and ensuring effective ex...
Reposted 3 weeks ago
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
4 weeks ago
$110K - $130K *
Lead the charge in harmonizing product transfers, ensuring compliance and quality across global assignments while collaborating with cross-functional teams to enhance efficiency and product integrity...
Reposted 4 days ago
Manager, Enterprise Data Management
$108K - $130K *
Unlock the potential of our data governance program by managing the MDM platform, ensuring data integrity, and collaborating with cross-functional teams to drive actionable insights across our expandi...
2 days ago
Business Development Manager (CRO)
$110K - $130K *
Empower business growth by leveraging your scientific expertise and sales acumen. Drive client engagement and forge strategic alliances in the US and Asia, delivering tailored solutions that enhance b...
6 days ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.