Principal Scientist Jobs

Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.

What Does a Principal Scientist Do?

Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.

Skills and Qualifications

Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.

Principal Scientist Salary and Career Outlook

Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.

Find Principal Scientist Jobs on Ladders

Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.

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$85K - $110K *

Unlock potential by driving payer policy strategies and relationships to enhance reimbursement for genetic testing. Collaborate with internal teams and external stakeholders to navigate complex health...

Burlington, NCRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $120K *

Lead the charge in quality engineering for critical assessment platforms, driving testing excellence and automation maturity. Collaborate with cross-functional teams to ensure reliability and scalabil...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$116K *

Drive impactful site activation strategies, collaborating with cross-functional teams to ensure timely delivery of clinical projects while enhancing communication and mitigating risks throughout the p...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$220K - $275K *

Elevate your career by leading global CMC regulatory strategies for biologics. Collaborate with cross-functional teams, ensure compliance, and drive successful product development while mentoring a hi...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Lead the SAP Analytics strategy and implementation, driving innovation in analytics solutions. Collaborate with stakeholders to deliver insights and manage teams, ensuring successful deployment of SAP...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $160K *

Drive SAP Analytics strategy and implementation, leading teams in deploying solutions across SAP Analytics Cloud, BW, and S/4HANA. Collaborate with stakeholders to deliver insights and manage analytic...

CanadaRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$189K - $246K *

Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$172K - $202K *

Unlock innovative insights and strategies in procurement and supply chain leadership. Collaborate with executives to drive actionable solutions, analyze market trends, and enhance client engagement th...

United StatesRemote

1 month ago

  •   11 - 15 years exp.  •   Business Services

$175K - $210K *

Lead the charge in shaping post-quantum security solutions. Drive partnerships, develop the semiconductor ecosystem, and empower the commercial team with technical insights to create demand and establ...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Empower consumer experiences by leading product strategy and execution for innovative genomics solutions. Collaborate with cross-functional teams to enhance user satisfaction and drive adoption throug...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $175K *

Lead the charge in advancing oncology diagnostics by managing a team of bioinformaticians and data scientists, driving product development, and ensuring high-quality analysis and validation of ctDNA-b...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $242K *

Lead advanced analytics initiatives to enhance MAU insights, driving growth through experimentation and causal inference. Collaborate across teams to establish standards and leverage AI for scalable s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$128K - $254K *

Drive the successful delivery of Phase I-IV clinical trials by leading cross-functional teams, managing project timelines, budgets, and quality standards while fostering strong client relationships an...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$191K - $258K *

Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$123K - $217K *

Drive your career with impactful cross-functional programs, leading initiatives from planning to launch. Collaborate with diverse teams to navigate complexity, ensuring successful delivery and continu...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $240K *

Lead scientific strategy for clinical development of BHB-1893, collaborating with cross-functional teams to ensure data integrity and regulatory compliance. Drive protocol design, data analysis, and e...

San Francisco, CARemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the charge in optimizing operational activities within the DHMS program, ensuring compliance and driving continuous improvement. Collaborate with stakeholders to implement effective strategies an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$201K - $251K *

Engage with Key Opinion Leaders to drive strategic marketing initiatives, leveraging clinical expertise to influence oncologists and enhance brand strategy. Collaborate cross-functionally to execute i...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead the charge in driving growth within the industrial market sector, leveraging client relationships and market intelligence to enhance profitability and pipeline strength across environmental servi...

Austin, TXRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$113K - $142K *

Elevate your career by joining our dynamic team to design, develop, and optimize bioinformatics software tools and systems, ensuring robust functionality and compliance in a fast-paced, innovative env...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Engineer innovative mechanical solutions by translating architectural concepts into practical designs. Collaborate across engineering disciplines while leading HVAC standards and ensuring effective ex...

Fort Worth, TXRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$186K - $233K *

Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in harmonizing product transfers, ensuring compliance and quality across global assignments while collaborating with cross-functional teams to enhance efficiency and product integrity...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $130K *

Unlock the potential of our data governance program by managing the MDM platform, ensuring data integrity, and collaborating with cross-functional teams to drive actionable insights across our expandi...

Jacksonville, FLRemote

2 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Empower business growth by leveraging your scientific expertise and sales acumen. Drive client engagement and forge strategic alliances in the US and Asia, delivering tailored solutions that enhance b...

Milford, MARemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What does a Principal Scientist do?question toggle

    A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.

  • What qualifications are commonly required for Principal Scientist jobs?question toggle

    Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.

  • How much do Principal Scientists earn?question toggle

    Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.

  • Where do Principal Scientists work?question toggle

    Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.

  • How can I find Principal Scientist jobs on Ladders?question toggle

    Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.