Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Staff Technical Program Manager
$120K - $145K *
Drive execution of complex technical initiatives, translating business vision into actionable programs. Collaborate with cross-functional teams to ensure alignment with company objectives and measurab...
2 weeks ago
Neuroscience Specialist, Health and Science Professional - Melbourne, FL
$76K - $199K *
Drive your career with a dynamic role focused on sales growth and customer engagement in the healthcare sector. Utilize your analytical skills and product knowledge to develop strategies that enhance...
Reposted today
$130K - $165K *
Lead clinical data management efforts by overseeing project timelines, ensuring quality deliverables, and facilitating communication among stakeholders. Drive data integrity and compliance while mento...
2 weeks ago
Senior Regulatory Affairs Consultant - Regulatory Project Manager
$120K - $145K *
Join a team that shapes global regulatory strategy in a fast-paced environment. You will lead comprehensive regulatory plans, ensuring alignment and execution from development to post-marketing, impac...
Reposted 1 week ago
Senior Clinical Operations Manager, Canada/USA, remote
$110K - $130K *
Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...
3 weeks ago
Specialist, Product Program Management
$85K - $95K *
Drive the end-to-end delivery of complex curriculum projects, collaborating across teams to ensure high-quality outcomes that meet business and learner needs while managing risks and stakeholder expec...
2 days ago
Associate Director, Study Operations Manager - Nonclinical Toxicology
$129K - $231K *
Elevate nonclinical toxicology operations by managing study execution, ensuring compliance, and fostering collaboration across teams to advance innovative therapies for sleep-wake disorders. Drive acc...
Reposted today
Principal Group Product Manager- AL Labs
$170K - $243K *
Transform product innovation by leading AI-driven strategies and experiments, collaborating across teams to enhance software solutions and improve employee experiences in a dynamic, fast-paced environ...
2 weeks ago
$80K - $95K *
Lead the charge in program management excellence, ensuring seamless operations and compliance across diverse teams while supporting critical Air Force contract initiatives and rapid-response readiness...
2 weeks ago
Principal Financial Analyst, OCI Virtual Networking
$84K - $187K *
Unlock potential by partnering with engineering and finance teams to drive financial strategy, optimize investments, and deliver actionable insights that enhance product performance and operational ef...
4 weeks ago
Sr. Software Integration Engineer
$120K - $160K *
Empower your career by designing and building automated solutions for software integration and deployment. Collaborate across teams to create a structured knowledge base and enhance software managemen...
Today
Sr Account Director, Business Development (Bioanalytical Labs) -US -San Francisco
$160K - $185K *
Unlock growth through consultative sales in clinical research. Collaborate with biotech leaders to enhance global health by managing strategic accounts and delivering innovative solutions that advance...
Reposted 2 weeks ago
Senior Principal -Western Markets and Regulatory Policy
$95K *
Drive the transition to clean energy by leading advocacy for western wholesale electricity market development. Collaborate with utilities and policymakers to shape an efficient market strategy that su...
Reposted today
Senior Clinical Scientist - Oncology - Home Based
$110K - $130K *
Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...
2 weeks ago
Drug Discovery Resource Outsourcing Manager
$110K - $130K *
Engage in early-stage drug discovery by triaging research requests, managing CRO partnerships, and ensuring seamless execution of outsourced projects. Leverage scientific expertise and Mandarin fluenc...
3 weeks ago
$120K - $145K *
Shape the future of digital transformation by leading a dynamic team to deliver innovative solutions that enhance business efficiency and customer experience across multi-functional AWS programs...
2 weeks ago
Director, Global Corporate Learning Management Systems
$211K - $264K *
Transform learning experiences by leading the strategy and operations of our enterprise learning technology ecosystem, ensuring effective governance and seamless integration across platforms to enhanc...
3 days ago
Senior Clinical Trial Manager - Metabolic - U.S.
$112K - $222K *
Lead clinical site management teams through project lifecycle, ensuring effective monitoring and communication. Drive project deliverables, budget management, and sponsor engagement to achieve impactf...
Reposted 2 weeks ago
Research Engineer, Remote Sensing
$115K - $172K *
Transform cutting-edge remote sensing technologies through collaborative research, algorithm development, and sensor data analysis. Contribute to innovative projects while shaping future research dire...
1 week ago
Group Project Manager, Healthcare and Pharmaceutical Advertising
$120K - $150K *
Champion integrated project management for complex pharmaceutical advertising, leading cross-functional teams to ensure timely delivery within scope and budget while mentoring junior staff and enhanci...
2 weeks ago
FSP Associate Manager Clinical Operations
$95K - $115K *
Drive operational excellence by leading clinical teams, ensuring effective training, resource allocation, and performance management. Collaborate with senior management to enhance project delivery and...
Reposted 1 week ago
Senior Technical Program Manager
$125K - $150K *
Transform complex customer implementations into seamless successes by owning the delivery lifecycle, driving technical discussions, and ensuring stakeholder satisfaction from kickoff to go-live. Your...
1 week ago
Project Management Lead, Science
$110K - $130K *
Drive project delivery excellence by architecting frameworks, managing resources, and synchronizing teams. Lead cross-functional initiatives, optimize processes, and mentor project managers to ensure...
2 weeks ago
Sr Dir Regulatory Intelligence & FDA Engagement
$203K - $305K *
Transform regulatory intelligence by leading a global strategy that identifies and implements evolving regulatory requirements across diverse healthcare sectors, ensuring compliance and strategic alig...
2 days ago
Business Development Manager (BioPharma Partnerships)
$92K - $139K *
Join a team that's driving growth by expanding biopharma collaborations. You'll identify opportunities, negotiate agreements, and manage partnerships to enhance market share and revenue, contributing...
2 days ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.