Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Staff Engineer, Identity & Access Management (IAM)
$180K - $212K *
Pioneer innovative IAM strategies to enhance security across cloud and on-premise infrastructures. Collaborate with cross-functional teams to implement robust identity governance and access management...
4 weeks ago
Manager, Regulatory Affairs - US
$121K - $161K *
Drive regulatory excellence by managing submissions, guiding teams, and ensuring compliance. Utilize your expertise to support global projects and foster collaboration in a fast-paced environment focu...
Reposted today
$190K - $240K *
Champion the design and engineering of a cutting-edge perfusion system, leading a team to innovate and scale operations while ensuring quality and reliability in medical device manufacturing...
2 weeks ago
$110K - $130K *
Lead the charge in total rewards management, overseeing payroll and benefits operations while enhancing employee experience through effective process improvements and cross-functional collaboration...
6 days ago
Executive Director, Clinical Supply Management
$280K - $300K *
Shape the future of clinical supply management by leading strategy and execution for transformative therapies. Collaborate cross-functionally to ensure timely delivery of investigational products, whi...
3 weeks ago
Senior Manager of Release Train Engineering
$145K - $193K *
Join a high-impact team as you lead and coach TPMs and RTEs, ensuring successful technical program delivery and Agile execution across complex projects, while fostering collaboration and continuous im...
Reposted yesterday
$110K - $159K *
Make your mark at the forefront of innovation as a Senior Technical Project Manager, overseeing proposal development, facilitating cross-functional collaboration, and ensuring successful project execu...
Reposted 2 weeks ago
Sr. Director, Integrated Evidence Generation Lead
$175K - $210K *
Lead pioneering evidence generation initiatives to inform oncology product strategies and lifecycle management through cross-functional collaboration and data-driven decision-making...
Reposted 1 week ago
Managing Director, Assessment & Human Capital
$170K - $230K *
Drive strategic growth and innovation in AI-enabled assessment and workforce solutions. Lead high-impact projects, foster collaboration, and enhance AIR's national leadership in education and workforc...
1 week ago
Principal Consultant - Senior SAP Sales Executive
$150K - $180K *
Transform the SAP sales landscape by leveraging your extensive network and expertise to drive new business acquisition in the manufacturing sector. Own the full sales cycle, from lead generation to cl...
1 week ago
$120K - $130K *
Transform your career by designing and delivering complex full-stack solutions using Java, Spring Boot, and Angular. Collaborate with teams to enhance engineering quality and lead technical initiative...
Reposted 5 days ago
Staff Product Manager, Growth & E-commerce Experimentation
$161K - $190K *
Transform the digital commerce experience by owning a high-velocity experimentation roadmap. Collaborate across teams to enhance customer journeys, improve conversion rates, and establish a robust exp...
3 weeks ago
$162K - $243K *
Join a team that's dedicated to advancing clinical trials through strategic oversight and collaboration. Lead project management efforts globally, ensuring quality, cost, and timeline objectives are m...
2 weeks ago
$139K - $209K *
Elevate your career by leveraging scientific expertise to drive sales growth in the life sciences sector. Collaborate with customers to align their research needs with innovative solutions, fostering...
2 weeks ago
FSP Sr Clinical Research Associate
$80K - $95K *
Engage in clinical monitoring and site management, ensuring compliance with protocols and regulations. Collaborate with investigational sites to maintain data integrity and audit readiness while manag...
Today
FSP Sr Clinical Research Associate
$80K - $95K *
Drive clinical monitoring excellence by ensuring compliance with protocols and regulations. Collaborate with investigational sites to enhance data integrity and subject safety while managing documenta...
2 days ago
Associate Medical Director, Clinical Research
$225K - $281K *
Join a team that's pushing the boundaries of oncology research! This key role involves designing and leading clinical trials, ensuring data integrity, and collaborating with global experts to advance...
Reposted 5 days ago
$90K - $113K *
Engage in clinical monitoring and site management, ensuring compliance with protocols and regulations. Collaborate with investigative sites and internal teams to uphold data integrity and subject safe...
1 week ago
$85K - $100K *
Deliver advanced field service support for Promega instrumentation, ensuring installation, training, and repairs meet customer service standards. Collaborate with teams to enhance service documentatio...
1 week ago
Principal Portfolio Manager, Infrastructure Development
$175K - $210K *
Lead the execution of energy infrastructure investments, managing complex programs from development to delivery. Drive governance, cross-functional coordination, and external partnerships to ensure ti...
Today
Director of Business Process Excellence
$155K - $205K *
Champion process excellence by optimizing workflows and driving cross-functional improvements. Collaborate with teams to enhance operational efficiency, reduce costs, and elevate service quality throu...
4 weeks ago
Director, GCP Inspection Management- Americas
$172K - $232K *
Lead the GCP Inspection Management team to ensure inspection readiness and compliance. Oversee strategy development, cross-functional collaboration, and risk mitigation for successful regulatory inspe...
4 weeks ago
$155K - $210K *
Lead complex programs and strategic client engagements, driving technology transformation and sustainable business value. Act as a trusted adviser to C-level stakeholders, shaping program vision and e...
3 weeks ago
Staff Software Engineer, Java Backend
$120K - $170K *
Lead engineering efforts by writing production code and mentoring a team. Drive modernization initiatives through Java microservices while managing performance and growth of engineers. Collaborate wit...
Reposted yesterday
Staff Technical Program Manager
$120K - $145K *
Drive execution of complex technical initiatives, translating business vision into actionable programs. Collaborate with cross-functional teams to ensure alignment with company objectives and measurab...
2 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.