Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Senior Project Manager, Marketing PMO
$110K - $130K *
Lead complex, cross-functional marketing initiatives from planning to execution, driving accountability and collaboration across teams while enhancing project management processes and methodologies fo...
3 weeks ago
$145K - $165K *
Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...
1 week ago
Principal Strategic Researcher
$173K - $290K *
Join a team that's redefining strategic research by tackling complex, ambiguous challenges. Collaborate with product, design, and engineering leaders to shape impactful insights that drive business de...
3 weeks ago
$130K - $160K *
Lead all HR functions in a dynamic biotech environment, enhancing employee experience and compliance while driving scalable processes and supporting leadership. Engage with teams to foster growth and...
1 week ago
$175K - $185K *
Unlock potential by leading global product strategies that drive growth and innovation. Collaborate cross-functionally to prioritize customer needs, enhance product performance, and support internatio...
1 week ago
$150K - $180K *
Shape the future of AI engineering by leading technical outcomes, architecting production systems, and mentoring teams. Collaborate with stakeholders to drive innovation and ensure operational excelle...
2 weeks ago
$80K - $95K *
Join a team that's driving strategic sourcing initiatives, managing supplier relationships, and optimizing procurement processes to deliver significant value across multiple categories in a dynamic en...
1 week ago
Manager, CMC Quality, Pulmovant
$110K - $130K *
Lead quality oversight for drug manufacturing, ensuring compliance with cGMPs. Collaborate with vendors on batch record review and product disposition for global clinical programs, thriving in a dynam...
2 weeks ago
$72K - $110K *
Champion environmental project success by managing scopes, schedules, and budgets. Collaborate with multi-disciplinary teams and clients to deliver high-quality solutions while mentoring junior staff...
Reposted 6 days ago
Global Lead Project Manager (FSP), US (remote)
$120K - $145K *
Drive project success as a Global Lead Project Manager, overseeing cross-functional teams to ensure timely, quality delivery of clinical trials while managing customer expectations and financial stewa...
Reposted 2 weeks ago
Business Performance Manager, Human Genetics
$104K - $141K *
Lead the charge in transforming Human Genetics strategy into actionable plans, ensuring measurable progress across R&D. Collaborate with cross-functional teams to align priorities and drive successful...
1 week ago
Senior Product Manager, AI Operations
$150K - $200K *
Unlock potential by transforming workflows and enhancing team capabilities through AI. Collaborate across departments to implement innovative solutions that streamline operations and drive sustained a...
Reposted today
$120K - $160K *
Unlock potential by leading complex federal contract negotiations and management. Collaborate with cross-functional teams, ensuring compliance and driving strategic solutions to support business growt...
Reposted 3 weeks ago
$125K - $150K *
Oversee large-scale Federal contracts, ensuring compliance and strategic alignment. Leverage expertise in negotiation and federal regulations to enhance program execution, drive business growth, and e...
Reposted 3 weeks ago
Program Executive, Early Phase
$300K - $350K *
Join a team that's driving innovation in early clinical development. Lead cross-functional strategies and execution for a high-priority program, ensuring alignment and decision-making to advance a pot...
3 weeks ago
$135K - $160K *
Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...
1 week ago
FSP - Sr Regulatory Program Manager - client dedicated
$120K - $145K *
Join a team that's redefining regulatory excellence by leading global strategies for product development and post-marketing. Drive cross-functional collaboration and ensure timely execution of regulat...
Reposted 3 weeks ago
$160K - $190K *
Empower your career by partnering with the Science Leadership Team to drive strategic initiatives, enhance operational effectiveness, and translate scientific vision into impactful outcomes across div...
2 weeks ago
$127K - $203K *
Champion the AI Center of Excellence by managing the roadmap, prioritizing initiatives, and ensuring alignment with corporate goals. Drive stakeholder engagement and deliver measurable business outcom...
Today
Senior Director, Clinical Diagnostics and Precision Medicine
$242K - $403K *
Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...
3 weeks ago
Translational AI Scientist/Engineer
$150K - $185K *
Unlock potential by designing and deploying AI systems that enhance translational science, enabling evidence-based recommendations for drug discovery and target validation through innovative technolog...
3 weeks ago
$128K - $184K *
Empower sales growth by driving strategic account management and territory development in the biopharmaceutical sector, fostering relationships and delivering innovative solutions to enhance client su...
1 week ago
Lead Bioinformatics & Machine Learning Scientist (Epigenomics)
$146K - $180K *
Advance your career by leading innovative bioinformatics projects focused on machine learning for early cancer detection. Collaborate with experts to develop cutting-edge methods and mentor a dynamic...
Today
Senior Manager, Evidence & Insights (RWE & HEOR)
$90K - $110K *
Join a team that's shaping evidence strategies and insights in health economics and outcomes research. Lead client engagements, oversee analytics, and drive impactful decision-making in biopharma and...
1 week ago
21GRAMS- Senior Delivery Manager
$95K - $100K *
Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...
1 week ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.