Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$134K - $184K *

Shape the future of customer success by leading a high-performing team, optimizing operations, and driving engagement and retention strategies to achieve key performance indicators and enhance client...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $200K *

Unlock potential by driving sales strategies in the healthcare sector. Collaborate with C-Level executives, generate new opportunities, and enhance market presence while navigating complex enterprise...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Explore a unique opportunity to shape a new ambulatory surgery center, collaborating with a skilled team to deliver exceptional patient care and innovate surgical practices in a state-of-the-art facil...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Lead the charge in delivering comprehensive medical care, collaborating with a multidisciplinary team to enhance patient outcomes in both inpatient and outpatient settings while educating future healt...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$172K - $210K *

Transform regulatory operations by leading submission strategies, managing systems, and ensuring compliance across portfolios while collaborating with cross-functional teams for successful outcomes...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$60K - $129K *

Transform behavioral healthcare for children by utilizing clinical expertise to assess and enhance care plans, ensuring effective and culturally competent support that promotes optimal outcomes and re...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Shape the future of semiconductor advisory by leading transformative projects, driving multimillion-dollar sales, and mentoring a dynamic team of consultants to deliver innovative solutions in supply...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Join a dynamic team to optimize clinical operations, ensuring compliance and performance excellence. Lead and develop Clinical Research Associates while managing resources and enhancing training initi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$136K - $204K *

Drive the development of AI and technology certification programs for law schools, enhancing legal education engagement and establishing Clio as a trusted partner in the academic community through inn...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Drive operational excellence by enhancing reliability and performance of a SaaS platform. Collaborate with development teams to implement automation, incident management, and observability practices...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Drive data integrity and operational excellence by resolving complex payer data issues, collaborating across teams, and enhancing data quality for value-based care initiatives. Play a key role in opti...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $98K *

Transform customer experiences by leading complex software implementations, ensuring seamless onboarding, testing, and launch activities. Leverage advanced product knowledge and project coordination s...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$129K - $162K *

Empower healthcare transformation by providing legal support in payor contracting. Collaborate with cross-functional teams to negotiate, draft, and manage contracts, ensuring compliance with regulator...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by driving research in prediction markets, developing alpha signals, and collaborating through the entire model implementation process. Guide projects from data analysis to live tradi...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Elevate patient recruitment strategies across clinical trials. Lead global initiatives, optimize engagement, and ensure compliance through innovative solutions and effective collaboration. Drive enrol...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$79K - $150K *

Elevate billing processes by overseeing design and governance within Oracle, ensuring efficiency and accuracy in invoicing. Collaborate with cross-functional teams to drive improvements and mentor jun...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$190K - $214K *

Champion HCP engagement by leading personal promotion strategies and speaker programs. Collaborate cross-functionally to develop compliant promotional tools that enhance brand objectives and optimize...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $216K *

Advance the deployment of MHS GENESIS across multiple sites, ensuring seamless integration and performance outcomes while managing stakeholder relationships and project deliverables throughout the lif...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$175K - $210K *

Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $110K *

Analyze diverse research projects to provide actionable insights for leadership. Collaborate with a dynamic team, utilizing AI tools and your curiosity to tackle complex questions and deliver clear, c...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $180K *

Analyze consumer behavior and trends to produce engaging stories on technology and culture. Collaborate across various topics, from e-commerce to marketing, while maintaining high journalistic standar...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Media

$80K - $95K *

Drive clinical quality improvements by translating needs into training and processes. Own record audits, partner with Product and Engineering for automation, and support clinical projects to enhance p...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$117K - $161K *

Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$92K - $120K *

Lead a dynamic team of Client Contract Managers to optimize renewal strategies, drive retention, and enhance operational excellence through effective leadership and cross-functional collaboration. Ele...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$85K - $95K *

Unlock potential by providing strategic business analysis and project management expertise. Collaborate with stakeholders to enhance processes, ensure data integrity, and deliver impactful business so...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.