Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$89K *

Join a dynamic team to lead clinical operations at a Behavioral Health Urgent Care, ensuring exceptional customer experiences, staff development, and compliance with standards while driving quality in...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$203K - $245K *

Unlock potential by leading a national team of Thought Leader Liaisons to enhance KOL engagement and advocacy in oncology. Drive strategic initiatives, foster collaboration, and ensure compliance whil...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$113K - $188K *

Shape the future of healthcare reimbursement by developing and implementing payment policies that enhance accuracy, compliance, and provider experience in a dynamic payer environment. Collaborate with...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$150K - $206K *

Transform the accounting landscape by leading strategic initiatives that enhance operational efficiency, standardize processes, and drive technology integration, all while ensuring public company read...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$200K - $275K *

Transform financial planning and analysis for diverse divisions, optimize performance insights, and shape executive decisions. Drive accountability through robust forecasting, modeling, and communicat...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$85K *

Champion efficient clinical operations by overseeing nursing staff and ensuring high-quality patient care. Coordinate workflow and manage resources to create a safe, supportive environment, while serv...

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $114K *

Engineer robust full stack enterprise applications in a dynamic AWS environment. Collaborate with cross-functional teams to design, develop, and maintain high-quality solutions while troubleshooting c...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$227K - $341K *

Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $165K *

Shape the future of patient care as a Clinical Pharmacist Practitioner, collaborating with a multidisciplinary team to manage advanced heart failure therapies and enhance patient outcomes through educ...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $205K *

Lead the charge in cybersecurity governance and risk management consulting. Drive client engagements, develop security frameworks, and mentor teams while ensuring alignment with industry standards and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$130K - $160K *

Empower the development of mission-critical applications on the ServiceNow platform, collaborating with stakeholders to deliver scalable solutions while ensuring compliance with federal standards and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$99K - $148K *

Manage and oversee inpatient Care Management and Social Work programs, ensuring compliance and effective care progression. Collaborate with multidisciplinary teams to enhance discharge planning and op...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Empower health systems with your PharmD expertise, driving effective implementations and customer success in our AI-driven pharmacy platform. Shape workflows, maximize ROI, and enhance adoption throug...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Healthcare

$300K - $350K *

Empower the future of reconstructive surgery by joining a collaborative team focused on clinical excellence and education, while having access to comprehensive resources for innovative patient care an...

1 month ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$200K - $278K *

Optimize clinical trial safety oversight, ensuring compliance and excellence in drug development through collaboration and expert medical consultation at every stage of the process...

Cary, NCRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $278K *

Lead the charge in providing medical oversight for clinical trials, ensuring adherence to regulations and safety protocols. Collaborate with teams and clients to enhance drug development processes fro...

Reposted 1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $288K *

Shape the future of finance by leading transformation initiatives, modernizing technology stacks, and integrating AI to enhance operational efficiency across multiple finance domains with measurable b...

Durham, NCRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $190K *

Unlock your potential by engaging key Gastroenterology stakeholders, driving product utilization, and exceeding sales goals through strategic collaboration and compliance in a dynamic healthcare envir...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$168K - $283K *

Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$153K - $268K *

Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $180K *

Champion innovation by developing full-stack web applications using TypeScript. Collaborate in a dynamic, remote-first team to deliver engaging user experiences, streamline operations, and lead techni...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $192K *

Join a team that's dedicated to driving demand in the Neurology Franchise. Collaborate with healthcare professionals and internal partners to achieve sales objectives while ensuring a patient-first ap...

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower clinical development by collaborating with Medical Directors to ensure scientific integrity and data quality in clinical trials. Engage with experts, analyze data, and manage project deliverab...

North Carolina, USRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$154K - $196K *

Unlock potential by leading strategic government programs, managing P&L, and driving operational excellence. Oversee contract delivery, mentor staff, and foster client relationships to ensure growth a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.