Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$180K - $258K *

Advance business growth by driving strategic sales across regions, nurturing client partnerships, and orchestrating multi-functional solutions to enhance value and performance in the biopharmaceutical...

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $190K *

Unlock end-to-end software solutions by designing and developing scalable features at the intersection of healthcare and technology. Collaborate with cross-functional teams to rapidly deploy impactful...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$189K - $246K *

Join a team that's shaping the future of metabolic health by leading a national field medical strategy. Drive cross-functional collaboration, manage a team of experts, and ensure compliance while achi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Lead engineering efforts by writing production code and mentoring a team. Drive modernization initiatives through Java microservices while managing performance and growth of engineers. Collaborate wit...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Transform your career by driving strategic partnerships in healthcare. Leverage your extensive relationships within benefits consulting to influence and expand business opportunities while collaborati...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$75K - $105K *

Tackle comprehensive project management for onboarding HME providers, driving digital transformation across healthcare. Collaborate strategically, enhance platform adoption, and leverage data insights...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $105K *

Take ownership of client assessments and treatment plans while supervising a team of behavior technicians. Collaborate with professionals to ensure effective care and stay current with ABA practices...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Transform lives as a Board Certified Behavior Analyst, leading assessments, crafting tailored treatment plans, and guiding a dedicated team. Collaborate with professionals to enhance care and stay at...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$116K *

Lead site activation efforts by coordinating with cross-functional teams to ensure timely and quality delivery of clinical projects. Drive strategic initiatives and mitigate risks while enhancing comm...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's dedicated to enhancing clinical operations through strategic site identification and management. Leverage your expertise to build relationships, track project timelines, and contrib...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$298K - $340K *

Join a dynamic team to lead strategic statistical programming initiatives, ensuring top-quality deliverables and compliance across diverse clinical trials. Collaborate with cross-functional partners t...

United StatesRemote

Reposted 3 weeks ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in managing informatics projects from planning to delivery, ensuring timely decision-making and risk management. Collaborate with cross-functional teams to enhance health information e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$240K - $339K *

Drive patient engagement by leading innovative strategies for the immunology portfolio. Oversee the patient journey, enhance support operations, and collaborate across teams to optimize outcomes and e...

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$103K - $161K *

Drive strategic growth by establishing and nurturing key partnerships with Enterprise Claims carriers, ensuring service excellence and collaboration across internal teams to enhance business outcomes...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$250K - $300K *

Join a team that's dedicated to providing exceptional pediatric anesthesia care while maintaining adult skills. Enjoy a collaborative environment, diverse case mix, and a flexible schedule with partne...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Empower your career by leading IT security initiatives, assessing risks, and driving remediation efforts across the enterprise. Collaborate with cross-functional teams to enhance security posture and...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Join a team that's dedicated to providing compassionate palliative care in a hospital setting. You'll collaborate with an interdisciplinary team to enhance patient quality of life and support families...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $220K *

Lead the charge in delivering exceptional neurology care as Section Chief, ensuring compliance, quality, and patient satisfaction while collaborating with healthcare teams to enhance service delivery...

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Advance your career with a remote role leading a claims team. Oversee investigations, manage workloads, and drive success while ensuring compliance with company standards and fostering team developmen...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$82K - $115K *

Innovate faculty management and student engagement strategies while coaching and supporting educators. Drive academic excellence and uphold performance standards within a dynamic educational environme...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Unlock potential by joining a global team focused on clinical research compliance. You will negotiate and interpret informed consent for biospecimens, shaping the future of precision medicine and ensu...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $135K *

Shape the future of clinical trials by leading site monitoring efforts, ensuring compliance, and fostering collaboration across teams. Drive quality and efficiency in trial execution while mentoring j...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to crafting persuasive copy across diverse marketing channels. Collaborate with creative minds to elevate brand messaging and engage audiences through innovative content t...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by driving strategic insights and operational excellence in a dynamic environment. Collaborate across teams to analyze complex problems, shape pricing strategies, and support market e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$133K - $210K *

Lead the charge in shaping security operations by architecting SIEM, driving automation, and mentoring a dedicated team. Your expertise will enhance threat detection and incident response, ensuring ro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.