Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$104K - $143K *

Unlock your potential by leading strategic initiatives that drive measurable business results. Collaborate with senior leaders to solve complex problems, evaluate opportunities, and translate strategy...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$121K - $240K *

Architect and evolve enterprise Salesforce architecture, driving scalable solutions aligned with commercial strategy, managing integration with Certinia, and leading AI inclusion for Sales, Marketing...

Durham, NCRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Unlock the potential of implementation science as a Senior Program Analyst, driving quality improvement and program evaluation initiatives. Manage processes, databases, and reporting to enhance projec...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Optimize client success by leading strategic relationships and enhancing revenue cycle performance. Drive measurable improvements, manage escalations, and ensure value realization across healthcare so...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$114K - $140K *

Engineer innovative health care delivery policies through quantitative analysis, leading projects that influence Medicare and Medicaid systems. Collaborate with multidisciplinary teams to evaluate and...

Durham, NCRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$130K - $155K *

Lead the charge in driving end-to-end strategy and discovery for complex client engagements. Collaborate with cross-functional teams to deliver actionable insights, build trusted relationships, and na...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $195K *

Elevate client relationships by managing key accounts, driving satisfaction and growth. Collaborate with internal teams to deliver tailored solutions, ensuring long-term success and measurable ROI for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$210K - $250K *

Drive clinical excellence and lead strategic initiatives in House Calls and GUIDE programs, ensuring alignment with value-based care standards and operational goals while fostering a culture of collab...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Champion innovative growth in surgical sales. Drive digital chest drainage adoption, develop U.S. strategies, and lead a high-performing team to expand market share in a dynamic, evolving environment...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$74K - $87K *

Transform customer experiences by leading Unanet ERP implementations, ensuring successful configurations and training for Government Contracting clients. Manage multiple projects, driving adoption and...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $106K *

Analyze and optimize Amazon DSP and paid search campaigns to drive results across Retail Media. Leverage data insights to enhance performance, ensuring KPI excellence while managing fast-paced, multif...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$225K - $275K *

Elevate healthcare standards by guiding medical policy and coding within a collaborative team. Leverage your expertise to enhance client relationships, improve payment accuracy, and drive strategic in...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join us in leading a dynamic clinic focused on improving the lives of children with Autism. You'll mentor clinicians, manage operations, and drive high-quality care while fostering a collaborative env...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Advance your career by providing vital engineering and consulting services across diverse projects. Engage in field investigations, engineering analyses, and client collaboration to ensure project suc...

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$126K - $173K *

Champion the development of Provider Direct Connect capabilities, driving product vision and strategy while collaborating with cross-functional teams to enhance provider engagement and deliver scalabl...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$106K - $155K *

Contribute to innovative radiation oncology treatments by developing precise dosimetry plans. Collaborate with a multidisciplinary team to enhance patient care in cancer management through effective t...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$143K - $219K *

Explore innovative AI solutions by designing and evaluating ML models for endpoint management and security. Collaborate with cross-functional teams to translate research into scalable product features...

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Transform healthcare service delivery by leading teams to optimize client satisfaction, compliance, and operational efficiency in a dynamic, growth-oriented environment focused on best practices and c...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Manage customer expectations by designing and scoping vulnerability management solutions, acting as the technical bridge between client security teams and engineering to ensure successful implementati...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$143K - $200K *

Innovate solutions as a Senior Appian Developer, tackling complex BPM challenges. Collaborate with teams to design, implement, and optimize high-performance applications while mentoring junior develop...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Champion patient safety by monitoring neuromuscular function during surgeries. Collaborate with surgical teams to ensure optimal outcomes through real-time data analysis and communication, making a si...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$122K - $204K *

Transform enterprise identity management by leading IAM architecture for AI workloads, ensuring secure access and integration across platforms. Collaborate with engineering teams to design and impleme...

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $165K *

Join us to drive the adoption of a groundbreaking product in cardiovascular care. This dynamic role requires strong sales skills and a commitment to enhancing patient outcomes through collaboration wi...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $140K *

Create innovative telecommunications designs that shape infrastructure across diverse building types, collaborating with multidisciplinary teams from concept through construction to enhance user exper...

1 month ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $140K *

Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.