Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$115K - $120K *

Transform mental health care by delivering remote therapy services in a structured, outcome-focused environment. Collaborate with care teams to provide effective treatment and maintain high clinical s...

North Carolina, USRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $148K *

Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$82K - $136K *

Lead the charge in optimizing advisor referral programs, ensuring high service levels and consistent advisor experiences while transforming operational workflows into scalable, repeatable processes...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $110K *

Contribute to exceptional patient care by providing orthopedic services in collaboration with physicians. This role involves direct patient interaction, clinical assessments, and coordination of care...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$74K - $137K *

Engage stakeholders to deliver innovative training programs on Direct Tax Compliance solutions. Collaborate with teams to enhance learning experiences through various formats, ensuring alignment with...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Media

$74K - $137K *

Elevate your career by delivering expert training in Direct Tax Compliance solutions, enhancing customer success through engaging learning experiences. Collaborate with teams to create impactful conte...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Media

$128K - $254K *

Drive the successful delivery of Phase I-IV clinical trials by leading cross-functional teams, managing project timelines, budgets, and quality standards while fostering strong client relationships an...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$98K - $163K *

Champion transformative financial management solutions by optimizing processes, enhancing efficiency, and implementing intelligent automation. Collaborate with clients and teams to drive impactful cha...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Elevate the clinical research field by leading technical teams, managing complex studies, and ensuring compliance with regulatory guidelines while delivering statistical programming excellence...

1 month ago

  •   Less than 5 years exp.  •   Staffing

$80K - $115K *

Empower individuals by providing therapeutic support to diverse populations. Shape treatment plans and foster growth in clients while collaborating with a dedicated clinical team. Drive positive outco...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Shape the future of geriatric care by providing clinical leadership and oversight. Drive quality improvement initiatives, mentor medical staff, and ensure exceptional outcomes for older adults in a co...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$79K - $97K *

Join a team that's dedicated to optimizing HR operations through hands-on support of Dayforce HCM and iCIMS. Leverage your expertise in HRIS to enhance processes, troubleshoot issues, and drive compli...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$125K - $150K *

Transform technology operations by leading IT and cybersecurity strategies, ensuring secure, scalable systems while enhancing employee support in a dynamic, remote-first environment. Collaborate acros...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$186K - $250K *

Unlock potential by leading a high-performing HEOR team to drive payer engagement and market access strategies, translating complex data into actionable insights that enhance patient access to innovat...

Raleigh, NCRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$96K - $207K *

Lead the charge in managing complex credit liquidations and rehabilitations. Collaborate with Portfolio Managers to optimize returns while ensuring compliance and risk management, fostering a positive...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$250K - $300K *

Transform patient care by joining a dynamic team of cardiologists, providing comprehensive outpatient services. Engage with patients through direct care, diagnostics, and management plans in a modern...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $180K *

Champion innovative oncology strategies by coordinating pre-award activities, enhancing client relations, and collaborating with global teams to drive successful outcomes in clinical research and busi...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Lead the charge in developing competitive oncology strategies, ensuring client needs are met through collaboration and expertise. Drive business development and enhance client relations while overseei...

Raleigh, NCRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$134K - $230K *

Pioneer a transformative training and quality organization, leading a diverse team to enhance utilization management operations across a vast healthcare network, ensuring high standards and continuous...

Charlotte, NCRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Join a team that's shaping innovative healthcare projects, guiding design excellence from concept to construction. Leverage your expertise to foster collaboration, mentor others, and ensure project su...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$88K - $105K *

Lead the charge in delivering innovative healthcare projects, guiding design excellence from concept to construction. Collaborate with teams, manage quality assurance, and mentor staff to achieve proj...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $115K *

Partner with us to enhance pediatric care by providing expert support in clinical settings. Utilize your skills to manage acute and chronic health conditions, ensuring quality service for children and...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Transform patient care by joining our dedicated team, fostering collaboration and community engagement while ensuring a safe, inclusive environment for all. Your commitment to quality and teamwork wil...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $106K *

Transform patient care by developing and implementing comprehensive nursing plans in home health settings, ensuring high-quality clinical coordination and compliance with regulations while collaborati...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion the development and execution of mission command training, mentoring unit leaders to enhance operational proficiency across various training domains. Collaborate with senior staff to ensure e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.