Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$90K - $110K *

Shape the future of HR technology by managing and optimizing our HRIS. Serve as a vital expert, collaborating across departments to enhance system performance, streamline processes, and ensure data in...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$185K - $235K *

Lead the charge in enhancing behavioral health services by providing clinical leadership, oversight, and consultation. Collaborate with teams to ensure high-quality care and compliance while driving c...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Lead comprehensive patient care as a Registered Nurse in a dynamic rehabilitation setting, collaborating with an interdisciplinary team to promote recovery and independence for patients with complex m...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $348K *

Transform clinical research through expert medical management and support. Collaborate with teams to ensure protocol integrity, provide training, and contribute to business development while maintaini...

Durham, NCRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Lead the charge in architecting innovative End User Computing solutions, collaborating with account teams and clients to drive strategy, deliver presentations, and enhance customer experiences while e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $124K *

Grow your career with a pivotal role in clinical oversight, mentorship, and training of BCBAs. Lead a dedicated team, enhance service delivery, and foster professional development within a supportive...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$195K - $341K *

Engage in clinical oversight and support staff training while ensuring adherence to quality standards and regulatory compliance in a collaborative healthcare environment focused on member care and ope...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Champion operational excellence in clinical trials by leading a team of Clinical Trial Managers. Drive strategic initiatives, ensure compliance, and enhance sponsor relationships while delivering stud...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Support patient evaluations by conducting psychological assessments and collaborating with a clinical team to enhance diagnostic outcomes and treatment plans. Leverage expertise in standardized testin...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$107K - $150K *

Engage with clients to design and implement advanced Physical Security Systems. Collaborate with top engineers on complex projects, ensuring high-quality solutions and customer satisfaction while mana...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$72K - $99K *

Empower students with exceptional needs by implementing tailored IEPs, collaborating with educational teams, and fostering an inclusive learning environment. Shape the future of special education thro...

1 week ago

  •   Less than 5 years exp.  •   Staffing

$180K - $215K *

Elevate regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability and...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$126K - $140K *

Shape the future of customer success by owning technical onboarding, guiding clients through implementation, optimizing deployments, and ensuring adherence to best practices for optimal use of the pla...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Lead the charge in delivering quality pediatric healthcare, establishing trust with families, and effectively diagnosing and treating childhood illnesses while promoting preventive care and healthy de...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$250K - $300K *

Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $130K *

Champion change in healthcare IT consulting by leading enterprise software projects and enhancing organizational workflows. Collaborate with leadership, drive client success, and deliver impactful res...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $300K *

Unlock potential by providing high-quality psychiatric care remotely. Enjoy clinical autonomy with robust support, flexible scheduling, and collaboration with leading mental health professionals. Grow...

RemoteRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $141K *

Pioneer excellence in program management by leading large-scale Healthcare IT initiatives. Collaborate with C-suite stakeholders to ensure strategic delivery, financial performance, and risk managemen...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$190K - $225K *

Shape the future of healthcare by driving strategic KOL engagement and insight generation in rare neurology. Collaborate with thought leaders to influence brand strategy and enhance patient outcomes t...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $108K *

Empower patient care by delivering compassionate nursing in a dynamic inpatient psychiatric setting. Collaborate with a dedicated team to ensure high-quality treatment and support for individuals in n...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$136K - $187K *

Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$280K - $340K *

Transform regulatory strategy and operations across CMC and clinical activities, leading a high-performing team to ensure compliance and successful product approvals from development through post-appr...

United StatesRemote

3 weeks ago

  •   15+ years exp.  •   Information Technology

$85K - $95K *

Transform the lives of children with autism as a Board Certified Assistant Behavior Analyst. Collaborate with a multidisciplinary team to create impactful behavior plans and support families in a nurt...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $95K *

Engage with children and families as a Board Certified Assistant Behavior Analyst, providing 1:1 ABA therapy, conducting assessments, and collaborating with a multidisciplinary team to enhance client...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Innovate clinical quality systems for scalable care delivery, ensuring standards meet payer expectations and driving measurable performance improvements across independent health providers...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.