Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$222K - $292K *

Elevate patient outcomes by leading global evidence strategies that showcase the value of therapies. Collaborate across functions to drive research programs, influence decision-making, and ensure scie...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Lead the charge in delivering complex federal digital services programs, ensuring strategic direction, operational excellence, and strong customer relationships across multidisciplinary teams while ma...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $125K *

Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$117K - $160K *

Lead the charge in underwriting E&S commercial property and casualty accounts. Manage risk assessments, develop competitive quotes, and collaborate with carriers to optimize profitability while achiev...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Drive operational excellence by developing and maintaining standards, ensuring consistency across markets, and collaborating with cross-functional teams to enhance processes and documentation for opti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $175K *

Shape exceptional user experiences by leading design for a unified legal platform. Drive user-centered solutions through research, collaboration, and design leadership to meet the complex needs of leg...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$204K - $255K *

Grow your career with us by driving innovation in legal services through AI. Collaborate closely with leadership and attorneys to develop transformative solutions that enhance practice efficiency and...

3 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $175K *

Accelerate patient care by optimizing therapy pathways and engaging key stakeholders. Collaborate with healthcare teams to enhance VTE awareness and program development, driving clinical initiatives a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $98K *

Contribute to the operational execution of clinical trials, ensuring compliance and efficiency from start-up to close-out. Collaborate with cross-functional teams to track documentation, manage record...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$103K - $154K *

Unlock advanced data solutions by leveraging Microsoft Azure and Power BI. Collaborate with teams to deliver high-quality analytics and reporting, while enhancing business intelligence capabilities th...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$91K - $112K *

Transform healthcare delivery by engaging with members to create tailored care plans, addressing complex needs, and collaborating with a dedicated team to promote optimal health outcomes and seamless...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $130K *

Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$210K - $250K *

Lead the charge in overseeing clinical trials, ensuring compliance and integrity while collaborating cross-functionally to deliver high-quality data that supports product development and regulatory su...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $173K *

Deliver high-quality emergency care as an Advanced Practice Provider, collaborating with a multidisciplinary team to manage diverse patient needs, perform procedures, and engage in ongoing clinical ed...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Bring your expertise to a senior role driving customer success in Pharmaceutical Regulatory. Lead implementations, manage accounts, and cultivate relationships to ensure long-term client satisfaction...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive the development of innovative RNA therapeutics by designing and executing in vivo studies, coordinating with CROs, and providing expertise in pharmacology to enhance therapeutic efficacy and saf...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$121K - $132K *

Engage as a key technical leader in enterprise AI/ML architecture, collaborating with clients to design scalable solutions. Drive AI development and deployment, ensuring alignment with business needs...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Lead end-to-end client implementations, ensuring timely and impactful project delivery while collaborating across teams to drive exceptional customer experiences and measurable outcomes in a dynamic h...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Champion public safety operations across North America, leading program directors to ensure effective training, deployment, and customer satisfaction while aligning resources and operational prioritie...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$150K - $214K *

Lead complex global regulatory project management activities, ensuring alignment across functions and successful submission milestones. Drive operational excellence and best practices to support a gro...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$178K - $307K *

Join us as a Business Unit Leader to drive national sales strategies and lead the Early Intervention team. Shape the future of Osteoarthritis treatment through impactful leadership, market access stra...

Reposted 4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$199K - $270K *

Tackle the complexities of backend engineering by developing robust API integrations, building ETL pipelines, and collaborating with cross-functional teams to enhance system reliability and performanc...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $160K *

Take ownership of B2B integrations as a key technical leader, collaborating across teams to deliver effective solutions that drive customer success and evolve with innovative IoT technology. Expect a...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$193K - $322K *

Join a team that leads the charge in advancing clinical AI and technology, shaping solutions that enhance clinician experience and patient outcomes while navigating complex healthcare environments...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.