Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$110K - $115K *

Join a team that's driving strategic insights in the biopharmaceutical sector. Engage collaboratively and develop analytic tools to support key decision-making while delivering impactful recommendatio...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the charge in optimizing human-system interactions for defense projects, ensuring seamless integration of advanced tools and workflows. Collaborate with multidisciplinary teams to enhance decisio...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$116K *

Lead site activation efforts by coordinating with cross-functional teams to ensure timely and quality delivery of clinical projects. Drive strategic initiatives and mitigate risks while enhancing comm...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's dedicated to enhancing clinical operations through strategic site identification and management. Leverage your expertise to build relationships, track project timelines, and contrib...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$298K - $340K *

Join a dynamic team to lead strategic statistical programming initiatives, ensuring top-quality deliverables and compliance across diverse clinical trials. Collaborate with cross-functional partners t...

United StatesRemote

Reposted 2 weeks ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$81K - $94K *

Champion operational excellence across inpatient oncology services, ensuring seamless coordination and support for clinical teams. Drive process improvements and regulatory readiness while managing st...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing informatics projects from planning to delivery, ensuring timely decision-making and risk management. Collaborate with cross-functional teams to enhance health information e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$68K - $92K *

Join a dedicated Transplant Social Work team to conduct psychosocial assessments, support patients through the transplant process, and collaborate with healthcare professionals to enhance patient care...

6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$285K - $375K *

Champion exceptional patient care as a Nocturnist Physician in a dynamic ED, providing critical support in a fast-paced environment with a focus on quality and collaboration. Join a team dedicated to...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$103K - $161K *

Drive strategic growth by establishing and nurturing key partnerships with Enterprise Claims carriers, ensuring service excellence and collaboration across internal teams to enhance business outcomes...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Analyze geological data and conduct surveys to assess earth's resources. Collaborate with teams to interpret findings and support environmental and land development projects. Stay informed on industry...

3 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$86K - $225K *

Champion patient care by delivering compassionate nursing on a diverse acute medical unit. Collaborate with a supportive team to enhance skills and advance your practice while ensuring high-quality ca...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead the charge in developing robust ML infrastructure and scalable applications, driving solutions for large-scale challenges while ensuring high-quality software design and functionality in a fast-p...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Empower your career by leading IT security initiatives, assessing risks, and driving remediation efforts across the enterprise. Collaborate with cross-functional teams to enhance security posture and...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $105K *

Lead the charge in optimizing on-the-job training programs, ensuring effective, standardized training to enhance safety and performance across operations through rigorous evaluation and continuous imp...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $250K *

Lead innovative drug discovery initiatives, driving strategic direction and scientific excellence. Collaborate across teams to translate complex data into actionable insights, enhancing development pr...

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $170K *

Unlock potential by leading innovative RWE analyses in oncology. Drive insights from complex data, implement advanced statistical methods, and leverage AI tools to enhance research efforts. Collaborat...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $130K *

Lead patient care initiatives by assessing, planning, and implementing individualized care strategies. Collaborate with healthcare teams to enhance patient outcomes and advocate for patient rights in...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $195K *

Lead the charge in providing expert Protection technical support within our engineering team, guiding projects from design to implementation, ensuring quality while fostering client relationships and...

Reposted 2 weeks ago

  •   15+ years exp.  •   Energy & Utilities

$145K - $195K *

Unlock potential by driving innovative Protection solutions for Transmission and Distribution projects. Collaborate with engineering teams, ensuring quality design and client satisfaction while mentor...

Reposted 2 weeks ago

  •   15+ years exp.  •   Energy & Utilities

$145K - $195K *

Empower your career by driving innovative protective relay system designs. Collaborate with a dedicated team to deliver high-quality engineering solutions tailored to client needs in the electric util...

Mansfield, MARemote

Reposted 2 weeks ago

  •   15+ years exp.  •   Energy & Utilities

$120K - $145K *

Join a dynamic team to drive growth in the Life Sciences sector, utilizing industry expertise to enhance client relationships and elevate marketing strategies. Position yourself as a strategic partner...

4 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$108K - $118K *

Join a dynamic team to lead complex programs, ensuring successful execution and alignment with strategic goals. Collaborate with stakeholders, manage resources, and drive quality improvement initiativ...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$349K - $399K *

Lead a high-performing nonclinical development team, shaping strategies for RNA therapeutics. Oversee pharmacology, toxicology, and DMPK, ensuring integration and collaboration across functions to dri...

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$345K - $395K *

Join a team that's shaping global regulatory strategies and CMC initiatives. Lead cross-functional collaboration to drive product development, regulatory approvals, and commercialization, while mentor...

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.