Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$285K - $296K *

Elevate clinical data systems and programming by leading strategic initiatives, ensuring compliance, and optimizing technology platforms for efficient clinical trials. Collaborate across teams to driv...

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$126K - $173K *

Champion the development of Provider Direct Connect capabilities, driving product vision and strategy while collaborating with cross-functional teams to enhance provider engagement and deliver scalabl...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $127K *

Champion optimal patient care by evaluating and treating diverse orthopedic and physical disorders. Collaborate with an interdisciplinary team to achieve rehabilitation goals while ensuring compliance...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$125K - $150K *

Transform healthcare service delivery by leading teams to optimize client satisfaction, compliance, and operational efficiency in a dynamic, growth-oriented environment focused on best practices and c...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Manage customer expectations by designing and scoping vulnerability management solutions, acting as the technical bridge between client security teams and engineering to ensure successful implementati...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$143K - $200K *

Innovate solutions as a Senior Appian Developer, tackling complex BPM challenges. Collaborate with teams to design, implement, and optimize high-performance applications while mentoring junior develop...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Champion patient safety by monitoring neuromuscular function during surgeries. Collaborate with surgical teams to ensure optimal outcomes through real-time data analysis and communication, making a si...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $170K *

Elevate client relationships and drive agency success by leading teams, coordinating strategic plans, and fostering collaboration across departments to create impactful healthcare solutions that reson...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $165K *

Join us to drive the adoption of a groundbreaking product in cardiovascular care. This dynamic role requires strong sales skills and a commitment to enhancing patient outcomes through collaboration wi...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$87K - $130K *

Manage comprehensive care for pregnant members, ensuring timely interventions, care coordination, and support for optimal maternal-fetal wellness through effective communication and collaboration with...

Massachusetts, USRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $140K *

Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $160K *

Join a dynamic team to lead large-scale NetSuite projects, enhancing client experiences through strategic project management and collaboration. Utilize your expertise in pre-sales and implementation t...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $245K *

Advance clinical excellence by leading hematology studies, ensuring data integrity and patient safety. Collaborate with cross-functional teams to design and execute clinical programs, driving innovati...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$127K - $160K *

Join a team that's dedicated to advancing patient care through expert pharmacotherapy in cardiothoracic transplant. Collaborate with interdisciplinary teams to optimize medication therapy and enhance...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$77K - $83K *

Champion skilled nursing services by delivering patient care, educating families, and collaborating with healthcare teams to ensure adherence to physician orders and care plans, enhancing patient outc...

6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$77K - $83K *

Drive impactful nursing care by administering skilled services to patients. Collaborate with healthcare teams to educate families and ensure adherence to care plans, enhancing patient outcomes through...

6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Drive impactful data science solutions by leveraging machine learning and causal inference expertise. Collaborate with multidisciplinary teams to design effective algorithms, analyze complex datasets...

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$300K - $375K *

Lead the charge in shaping actuarial strategies for Health Solutions, driving profitable growth through innovative insights and operational excellence while mentoring a high-performing team in a hybri...

Reposted today

  •   11 - 15 years exp.  •   Finance & Insurance

$120K - $140K *

Elevate healthcare consulting by leading complex actuarial projects, developing financial models, and advising clients on policy impacts. Collaborate with teams to analyze data, mentor analysts, and e...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$170K - $200K *

Lead and develop a high-performing field Medical Affairs team, translating strategy into actionable objectives. Engage with healthcare professionals and stakeholders to drive scientific exchange and e...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Join a team that's pioneering surgical robotic software solutions. Lead design and development efforts while mentoring engineers in a dynamic environment. Drive innovation and ensure high-quality perf...

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$136K - $214K *

Join a team that's redefining healthcare marketing by crafting compelling narratives and driving innovative go-to-market strategies for AI Care solutions across the Payor ecosystem. Leverage your expe...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $165K *

Lead the charge in managing strategic healthcare programs, enhancing integrated delivery systems through innovative project solutions and stakeholder engagement while mentoring junior analysts and ove...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $180K *

Drive corporate security initiatives by overseeing operations, compliance, and incident response. Leverage your expertise to enhance security posture, mentor teams, and align security strategies with...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $161K *

Join a team that's dedicated to ensuring drug safety, evaluating adverse events, and managing risk. Collaborate with cross-functional experts to uphold compliance while driving safety monitoring and p...

Waltham, MARemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.