Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$81K - $116K *

Champion patient care by performing C.A.T. scans, ensuring comfort and safety. Collaborate with radiologists to deliver high-quality imaging while adhering to safety protocols and maintaining a clean...

6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Join a team that's dedicated to providing comprehensive healthcare as you deliver expert assessment and support to patients. You'll operate autonomously in a collaborative hospitalist setting to enhan...

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$168K - $231K *

Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$268K - $466K *

Champion early clinical development in a dynamic team. Lead clinical research physician role for first-in-human studies, ensuring compliance and collaboration across scientific and regulatory areas to...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to delivering exceptional nursing care while mentoring staff and ensuring compliance with quality standards. This leadership role focuses on enhancing patient outcomes and...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$92K - $110K *

Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$93K *

Join a team that's dedicated to empowering patients through personalized occupational therapy. As a vital member of our rehab team, you'll implement recovery plans and enhance patient independence in...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$100K - $175K *

Grow expertise in Operational Technology security, leading critical engagements across industrial systems. Collaborate on advanced methodologies while mentoring others and contributing to pivotal rese...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $100K *

Transform patient care by providing 24/7 critical support to Rapid Response Teams, enhancing communication, and ensuring safety through comprehensive assessments and interventions in high-stakes situa...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Shape the future of patient care by leading nursing operations, mentoring staff, and ensuring compliance with quality standards. Drive initiatives for restorative and infection control programs while...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$78K - $100K *

Join our team to inspire and empower clients through personalized fitness programs. You'll develop exceptional relationships while excelling in business management and continuous professional growth—a...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$162K - $271K *

Drive strategic upstream marketing initiatives to shape product portfolios, influence leadership decisions, and foster innovation in a dynamic healthcare environment, ensuring alignment from discovery...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Pioneer in clinical pharmacy services, ensuring evidence-based medication therapy management for home infusion patients, collaborating with healthcare teams to optimize care delivery and patient outco...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$400K - $500K+*

Drive advanced neuroradiology practices in a 100% remote role, collaborating with top specialists while maintaining work-life balance. Enjoy a supportive physician-led environment focused on clinical...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$333K - $450K *

Transform clinical development by creating innovative strategies that enhance efficiency and safety in Phase 2/3 programs while collaborating with discovery teams and ensuring regulatory compliance...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $147K *

Shape your career by leading data integration initiatives that drive enterprise-wide consistency and governance. Collaborate with stakeholders to deliver trusted, scalable data products while ensuring...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$99K - $144K *

Unlock your potential as a Manager in Research Management, overseeing pre and post-award activities, ensuring compliance, and supporting financial operations within a dynamic research environment focu...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$170K - $190K *

Shape the future of our technology landscape by architecting scalable, secure systems that empower a high-growth environment through innovative SaaS and AI strategies. Lead the implementation of best...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$102K - $177K *

Pioneer innovative strategies in Knee Robotics; lead upstream marketing to define technology roadmaps and support new product development by translating clinical insights into actionable growth opport...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Engage in leading a dynamic team dedicated to delivering top-notch offensive security engagements, ensuring delivery quality and client satisfaction, while collaborating with sales to expand accounts...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform enterprise network architecture by leading LAN migration projects, ensuring seamless transitions to Cisco SDA fabric. Collaborate with cross-functional teams to execute plans, manage changes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $220K *

Engage with healthcare services and technology leaders to drive new business growth. Leverage a robust support system to build relationships, execute territory plans, and expand existing accounts whil...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $190K *

Join us to develop and execute innovative HCP marketing strategies for a groundbreaking autoimmune myositis launch, enhancing customer engagement across multiple channels and driving brand success in...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$200K - $290K *

Drive your career forward as a strategic leader in diabetes research, leveraging deep scientific expertise to guide innovative programs and enhance the drug discovery portfolio. Collaborate cross-func...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $95K *

Join as a critical team member to manage and enhance productivity platforms, ensuring stability, security, and user satisfaction. Collaborate across teams to drive operational maturity and navigate co...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.