Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Oncologist Jobs in South Dakota

Sort By: Relevance

$110K - $130K *

Elevate your career by supporting clinical studies through scientific expertise, operational delivery, and compliance. Collaborate with cross-functional teams and stakeholders to ensure successful tri...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Join a dynamic team as you manage oncology product promotions, build relationships with key stakeholders, and drive brand value through strategic engagement and innovative solutions in a competitive b...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Transform oncology care by driving product adoption and building relationships with key stakeholders. Leverage your expertise to exceed performance goals and ensure patient access to innovative therap...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Transform patient care by providing comprehensive oncology navigation and support. Collaborate with a multidisciplinary team to enhance patient experiences and outcomes through effective communication...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $230K *

Pioneer innovative oncology solutions by building strong relationships with key stakeholders, driving product adoption, and exceeding performance goals in a dynamic biopharma environment focused on pa...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Collaborate with healthcare professionals to enhance patient access and exceed performanc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand success in a competitive market. Leverage clinical ex...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by joining a dynamic Clinical Oncology Team, where you'll leverage your oncology and genomics expertise to enhance point-of-care products, drive clinical workflows, and support person...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Empower oncology practices by driving product adoption and building relationships with key stakeholders. Lead strategic initiatives to enhance patient access and optimize territory management while ex...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion statistical programming excellence in oncology clinical trials. Lead programming activities, collaborate with cross-functional teams, and ensure high-quality deliverables from study start-up...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Engage with key stakeholders to promote oncology products, build relationships, and drive brand value. Utilize market insights to develop strategic plans, ensuring patient access and exceeding perform...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$228K - $342K *

Elevate oncology project management by leading a high-performing team, ensuring operational excellence, and driving global programs through the development lifecycle while fostering strategic partners...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Transform the future of oncology care by driving product success and building strong relationships with key stakeholders. Lead initiatives that enhance patient access and deliver innovative solutions...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Elevate patient care by driving oncology product success through strategic relationships and innovative solutions. Lead efforts in territory management, market analysis, and collaborative engagement t...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand value in a competitive market. Lead strategic initiat...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$186K - $233K *

Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$156K - $235K *

Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$150K - $230K *

Lead the charge in oncology sales by building strong relationships with key stakeholders, driving product adoption, and ensuring patient access to innovative therapies. Collaborate with internal teams...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$235K - $270K *

Transform the landscape of oncology sales by driving growth within your territory. Collaborate with sales teams to identify opportunities, engage with key accounts, and promote cutting-edge diagnostic...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Transform the oncology landscape by driving product success and building strong relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Lead the charge in promoting innovative oncology solutions while building strong relationships with healthcare professionals. Drive performance goals and enhance patient access through strategic engag...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Empower your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovative...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$54K - $155K *

Lead the charge in telephonic case management, collaborating with patients and care teams to support quality healthcare delivery. Use clinical expertise to assess needs, implement strategies, and ensu...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $165K *

Drive customer success in Cancer Registry by building relationships, enhancing retention, and translating insights into actionable solutions. Collaborate across teams to improve outcomes and shape bus...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.