Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$130K - $192K *

Join a team that's implementing robust security controls across multiple brands, safeguarding employees and enhancing productivity through automation and secure practices. Collaborate globally while l...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$240K - $250K *

Lead the charge in designing core Windows components, ensuring performance and stability for millions of users. Collaborate with global teams to innovate and enhance product efficiency while mentoring...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$72K - $100K *

Join our dynamic team as a Sr. Credit Analyst, owning the underwriting cycle from application review to decision-making. Leverage your analytical skills to enhance credit processes and contribute to a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $90K *

Engage in data analysis and communications to support strategic planning and policy review for federal programs. Collaborate with stakeholders to ensure timely responses and effective execution of hig...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Advance operational efficiency by designing and deploying RPA solutions. Collaborate with stakeholders to identify automation opportunities, ensuring performance, security, and compliance in dynamic e...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Elevate data accuracy by analyzing user queries and improving AI responses. Collaborate with Product Management, Data Science, and Engineering to ensure Prism delivers trustworthy insights, enhancing...

Philadelphia, PARemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform data analysis in life sciences by ensuring accurate AI responses. Collaborate with Product Management, Data Science, and Engineering to enhance our conversational analytics platform, driving...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$141K - $212K *

Collaborate with cross-functional teams to drive signal integrity design, simulation, and testing for high-speed products, ensuring exceptional performance throughout product development cycles in var...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$63K - $114K *

Engage with healthcare providers to enhance performance in HEDIS, STARS, and value-based care. Develop contracts and foster partnerships while leveraging data analytics. Travel within territory requir...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive innovation in enterprise Identity and Access Management by designing, implementing, and optimizing IAM platforms. Collaborate across teams to enhance security and user experience while supportin...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $215K *

Innovate by driving real-time communications strategies and partner engagement. Shape impactful narratives during breaking news while building scalable programs that connect communications outcomes to...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$180K *

Drive the development of a cutting-edge platform, enhancing integrations and architecture for payroll and HR systems. Collaborate closely with a small team to ensure a successful launch and ongoing im...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Unlock potential by leading IT operations and identity management, transforming strategy into action. Drive technical excellence in Microsoft Entra ID, endpoint platforms, and SaaS integrations while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Innovate structural designs for light gauge and cold-formed steel systems, ensuring compliance with California codes. Collaborate across teams to enhance manufacturability and efficiency in modular an...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$91K - $194K *

Champion new account acquisition in the enterprise market, driving sales success through collaboration and strategic engagement. Leverage your expertise to achieve sales goals and foster strong relati...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$122K - $423K *

Transform integration solutions and platform architectures to enhance data flow and business processes. As a Director, guide initiatives, mentor leaders, and align technology strategies with enterpris...

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $130K *

Elevate our software engineering capabilities by designing and building modern, cloud-native data pipelines. Collaborate with diverse teams to ensure seamless project delivery and advocate for best pr...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $178K *

Advance your career by leading project management efforts in missile defense. Collaborate with diverse teams to drive technology development, manage budgets, and ensure efficient execution of innovati...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$200K - $250K *

Lead the charge in embedding Domino into complex enterprise IT landscapes. Drive strategic deployments, design robust architectures, and enhance AI/ML integrations while collaborating with cross-funct...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $251K *

Transform complex electrical designs for cutting-edge avionics systems. Collaborate with senior engineers to deliver hardware solutions on time while ensuring compliance with stringent technical requi...

4 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K - $160K *

Lead the charge in driving business development initiatives across the Northeast, fostering client relationships and collaborating with teams to enhance revenue growth in our forensics practice while...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$200K - $215K *

Advance the cloud platform capabilities, ensuring secure, reliable, and scalable product delivery while enhancing developer experience and shaping reliability practices in a mission-driven healthcare...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Drive the design and optimization of Oracle CX data architecture, ensuring effective data conversion and integration. Collaborate with cross-functional teams to enhance customer experience through inn...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$148K - $313K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them in architecting AI-first solutions within the Life Sciences sector, while driving internal initiatives and enhanc...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Champion technology strategy and optimization initiatives to enhance operational efficiency and scalability. Lead AI and automation projects while collaborating with leadership and vendors to align te...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.