Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$127K - $213K *

Shape the future of data architecture by leading innovative projects, defining standards, and implementing Data Mesh principles to enhance enterprise data products and governance across the organizati...

Lancaster, PARemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Lead the charge in shaping innovative Network Observability products, driving strategy from concept to launch. Collaborate with cross-functional teams to deliver solutions that empower operators to op...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Develop and implement MLOps strategy for enterprise-grade ML systems, driving model lifecycle management. Collaborate with teams to design scalable pipelines and ensure high reliability across ML solu...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead the design and implementation of Customer Order Management solutions, ensuring alignment with global standards while enhancing operational efficiency and stakeholder collaboration across regions...

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead the charge in shaping enterprise data architecture, guiding a team of architects to ensure data integrity and governance. Collaborate across functions to optimize data management practices and dr...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead and execute medical facility construction projects, ensuring compliance and successful delivery through effective team collaboration and project management...

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Shape the future of architectural design by leading a talented team to deliver innovative new construction projects that meet client expectations and adhere to industry standards, ensuring quality and...

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Transform your career by leading Microsoft Cloud security projects, deploying SIEM and XDR solutions, and enhancing customer environments. Collaborate with a dynamic team to drive innovation in Manage...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$250K - $350K *

Transform high-ticket sales by conducting inbound evaluation calls with pre-qualified prospects. Engage in deep discovery conversations, present exclusive membership, and enroll elite real estate prof...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$200K *

Drive your career by leading technical architecture and AI tooling development in a dynamic company transitioning to multi-platform solutions. Collaborate with teams, mentor talent, and engage with en...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$112K - $140K *

Elevate data solutions by building scalable pipelines and data lakes, optimizing analytics for decision-making. Collaborate in an agile environment to enhance data integrity and security while mentori...

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$117K - $158K *

Unlock potential by shaping and delivering AV and meeting room solutions at scale. This role combines technical expertise with project ownership, guiding clients from discovery to implementation while...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Drive the design and delivery of robust Applied AI solutions that transform business challenges into practical, production-ready systems while ensuring scalability, governance, and measurable impact f...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Champion business development to foster strategic partnerships in biotech, leveraging technical expertise and market insights to drive multi-million dollar enterprise revenue while shaping innovative...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$266K - $342K *

Champion innovative security solutions as a Senior Security Solutions Architect, bridging customer challenges with technical excellence. Drive strategic growth and mentor teams while engaging with sen...

4 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$108K - $162K *

Innovate in a strategic sales role, managing key accounts and driving revenue growth. Leverage technical expertise to build relationships and influence decision-making across the F5 solution portfolio...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$141K - $229K *

Unlock the potential of enterprise cloud adoption by leading research on public cloud platforms. Collaborate with technology executives to deliver actionable insights that drive strategic decisions an...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$92K - $122K *

Transform the campus network infrastructure by leading design, implementation, and support efforts. Collaborate with a dynamic IT team to ensure seamless communication and connectivity across a vast 6...

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Unlock potential by designing and managing AWS cloud infrastructure, ensuring high performance and scalability. Collaborate with engineering teams to optimize environments and enhance security, drivin...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Join a team that's shaping the future of Oracle Cloud solutions. As a key architect, you'll design and implement innovative Oracle CX applications, ensuring alignment with business goals while leading...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$111K - $150K *

Join a team that's advancing constructability practices across major projects. Lead the integration of strategies, mentor teams, and ensure consistent standards while driving continuous improvement in...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$164K - $228K *

Transform complex systems into a cohesive architecture by leading end-to-end solutions across CRM, billing, and integrations. Collaborate with stakeholders to address challenges and drive modernizatio...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $150K *

Empower a healthcare association by leading strategic initiatives, fostering partnerships, and driving revenue growth. Collaborate with stakeholders to enhance program excellence and ensure effective...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$110K - $130K *

Drive innovation by leading the design and implementation of complex systems, ensuring reliability and scalability while aligning engineering solutions with business objectives in federal IT moderniza...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$132K - $396K *

Inspire your career by leading transformative infrastructure initiatives for global organizations. Leverage your expertise in engineering and advisory to guide senior executives in optimizing and mode...

Reposted 6 days ago

  •   11 - 15 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.