Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Sr. Implementation Engineer (MANTL)
$96K - $120K *
Accelerate progress at the forefront of digital banking by leading complex client implementations, resolving advanced technical issues, and ensuring successful delivery of innovative solutions that al...
3 weeks ago
Director, Engineering- North America
$140K - $218K *
Transform the future of aerospace engineering by leading multi-site teams, enhancing technical capabilities, and driving operational excellence to meet customer demands and improve performance across...
2 weeks ago
$150K - $180K *
Elevate your career by leading infrastructure systems that drive engineering and product success. This hands-on role combines technical expertise with strategic vision, ensuring reliability and scalab...
4 days ago
$113K - $188K *
Join a dynamic team to design and develop high-performance ETL solutions, integrating data from diverse sources. Collaborate with cross-functional teams to optimize data workflows and ensure complianc...
3 weeks ago
Director, Technical Product Management
$150K - $180K *
Pioneer the strategy and execution of data platforms and AI products, leading cross-functional teams to enhance commercial life sciences solutions while driving revenue growth and product adoption in...
Reposted 1 week ago
$80K - $95K *
Empower seamless travel operations by managing critical systems and integrations. Collaborate with cross-functional teams to enhance performance and security of travel platforms, ensuring optimal user...
Today
$68K - $143K *
Support audit and compliance efforts for DoD financial systems, ensuring adherence to GAGAS and federal standards. Collaborate with stakeholders to enhance internal controls and audit readiness, drivi...
6 days ago
Specialist, Software Engineering
$110K - $183K *
Innovate the future of healthcare technology by developing scalable applications that streamline specialty prescriptions. Collaborate with a skilled team to enhance user experience and drive efficienc...
2 weeks ago
Principal Cloud Security Engineer
$159K - $210K *
Unlock potential by leading cloud security architecture and posture management across multi-subscription environments. Drive automation, establish guardrails, and collaborate with teams to ensure secu...
Today
$80K - $95K *
Empower your career by leading engineering projects, coordinating teams, and enhancing technical expertise while ensuring compliance with safety standards and managing project performance effectively...
2 weeks ago
$80K - $95K *
Lead a dynamic team to drive project success, ensuring optimal performance and efficiency while managing timelines, resources, and stakeholder communication throughout the project lifecycle...
2 weeks ago
$150K - $200K *
Transform the security landscape by leading corporate security and compliance initiatives. Own identity infrastructure, manage vendor relationships, and ensure customer trust while implementing robust...
2 weeks ago
$69K - $101K *
Champion the reliability of automated systems by providing expert technical support, troubleshooting complex issues, and collaborating cross-functionally to ensure operational excellence and seamless...
1 week ago
Principal AI Software Engineer
$250K - $300K *
Shape the future of AI-driven platforms by designing scalable applications and intelligent workflows. Lead initiatives that enhance operational efficiency and enable real-time insights, while mentorin...
Reposted 2 weeks ago
$145K - $175K *
Shape the future of software engineering by leading modernization efforts, solving complex technical challenges, and mentoring teams. Collaborate across product boundaries to enhance system architectu...
Yesterday
Senior Staff Platform Engineer
$215K - $307K *
Lead the charge in designing and evolving global cloud infrastructure, leveraging deep Azure expertise to build secure, scalable systems that enhance enterprise SaaS platforms and improve developer ex...
Today
Principal Product Marketing Manager (AI Gateway)
$145K - $175K *
Elevate your career by leading product marketing for AI governance solutions. Drive impactful narratives, engage with analysts, and create high-quality content to enhance visibility and credibility in...
2 weeks ago
$110K - $130K *
Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...
5 days ago
$135K - $145K *
Innovate data solutions by building and maintaining robust pipelines that empower critical processes. Collaborate with engineers and stakeholders to enhance data reliability and efficiency in a high-t...
1 week ago
Director, Information Security
$150K - $175K *
Lead the charge in managing client-facing security operations, overseeing a high-performing team, and acting as a trusted advisor. Drive incident response, tool management, and process improvement to...
2 weeks ago
Technology Services Technical Lead
$200K - $205K *
Drive the expansion of our Data Services & Analytics practice by leading technical delivery, managing client relationships, and overseeing project execution. Empower teams to deliver innovative data i...
3 weeks ago
Senior Project Manager - Data Center Construction
$115K - $201K *
Explore your potential by leading large-scale data center projects from planning to delivery. Manage budgets, schedules, and stakeholder communication while ensuring quality and safety in critical inf...
2 weeks ago
$88K - $105K *
Accelerate progress at customer success by managing a diverse portfolio, ensuring product adoption, and driving retention through proactive engagement and collaboration with cross-functional teams...
6 days ago
$86K - $137K *
Optimize project outcomes as you manage small to medium-sized initiatives. Collaborate across teams, navigate risks, and ensure timely delivery of quality solutions while enhancing communication and s...
Reposted 1 week ago
$116K - $157K *
Drive program success by leading cross-functional teams in executing IRAD efforts, ensuring alignment with technical, cost, and schedule goals from concept to transition, while fostering collaboration...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.