Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$100K - $115K *

Advance the payroll function for a diverse workforce, ensuring compliance and accuracy across multiple states. This hands-on role requires expertise in payroll systems and regulations, driving process...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$120K - $145K *

Drive excellence by leading model audits and mentoring a dynamic team. Collaborate on complex financial models, ensuring accuracy and strategic growth, while enhancing methodologies to deliver top-not...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$40K - $200K *

Join a dynamic team to drive business growth through consultative sales, building lasting client relationships, and delivering innovative payment solutions. This role offers uncapped earnings and oppo...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in managing complex public safety projects, ensuring timely delivery and high customer satisfaction. Oversee a diverse portfolio while collaborating with cross-functional teams to driv...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$205K - $231K *

Drive your career with impactful security initiatives that enhance product safety and foster responsible AI development. Collaborate across teams to elevate security practices and implement robust gua...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $180K *

Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $180K *

Transform digital services by collaborating on Azure cloud engineering, CI/CD, and observability. Support mission-aligned platform capabilities while ensuring secure, reliable, and maintainable soluti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $157K *

Shape impactful software solutions by bridging commerce and lab operations. Leverage AI tools to enhance workflows, design cloud-native services, and drive initiatives from concept to production in a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$161K - $242K *

Join a team that's driving strategic initiatives and digital transformation. Collaborate with senior leaders to tackle complex challenges, influence decision-making, and ensure successful execution of...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$75K - $158K *

Elevate your career as a Senior Business Systems Analyst, driving modernization initiatives in federal financial systems. Collaborate with teams to analyze data, implement solutions, and lead developm...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Drive enterprise-level technical solutions by analyzing system needs, coordinating design activities, and ensuring compliance with governance processes. Leverage your expertise to enhance performance...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Lead the charge in engineering and implementing a robust Intune solution for enterprise endpoint management, ensuring seamless integration and security across diverse devices within a mission-critical...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Drive provider network excellence by managing data integrity, overseeing contract configurations, and leading cross-functional teams to enhance operational efficiency and compliance in a dynamic TPA e...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $105K *

Join a team that's dedicated to enhancing system reliability and performance for critical defense projects. Leverage your engineering expertise to implement best practices and drive data-driven improv...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$86K - $138K *

Transform cloud financial operations in a mission-critical role, managing AWS costs and optimizing resources for a large-scale federal modernization initiative. Collaborate with diverse teams to enhan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$75K - $107K *

Drive strategic customer relationships and revenue growth for complex Public Sector and Education accounts, managing renewals, retention, and expansion opportunities while navigating intricate procure...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Join a team that's dedicated to delivering successful projects on time and on budget. As a key player, you'll drive project planning, coordinate with stakeholders, and ensure effective communication t...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $240K *

Lead the charge in enterprise sales by acquiring new logos and building strategic relationships. Drive growth in a competitive market, leveraging your expertise to navigate complex sales cycles and de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $125K *

Develop and execute strategies to enhance client engagement in the Military, Aerospace, and Government sectors, driving new business opportunities and managing key accounts to maximize value and foste...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $230K *

Drive impactful AI threat research marketing by transforming technical insights into compelling narratives. Collaborate with experts to enhance Cyera's authority and visibility in data security, while...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Elevate client success by managing complex projects, ensuring timely delivery, and maintaining budget integrity. Collaborate with diverse teams to drive engagement and optimize project outcomes from i...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $215K *

Lead innovative PR strategies to elevate brand visibility through dynamic storytelling, leveraging data insights and engaging fan experiences within a premier partnership, all in a fast-paced environm...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$168K - $281K *

Architect cutting-edge AI solutions as the design authority for Cyber Architecture. Lead a team of architects to define agentic frameworks and data fabric, ensuring robust AI/ML implementations across...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$198K - $205K *

Join a team that's shaping security strategies and solutions to protect digital landscapes. Lead the design and implementation of advanced security controls while mentoring engineers and driving impac...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.