Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$125K - $220K *

Drive security excellence by leading a dynamic team to enhance our cloud platform's security posture. Collaborate across departments to ensure compliance, resilience, and customer trust while fosterin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $192K *

Join a team that's implementing robust security controls across multiple brands, safeguarding employees and enhancing productivity through automation and secure practices. Collaborate globally while l...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$240K - $250K *

Lead the charge in designing core Windows components, ensuring performance and stability for millions of users. Collaborate with global teams to innovate and enhance product efficiency while mentoring...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$72K - $100K *

Join our dynamic team as a Sr. Credit Analyst, owning the underwriting cycle from application review to decision-making. Leverage your analytical skills to enhance credit processes and contribute to a...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Shape the future of defense programs by managing technology initiatives, supporting federal acquisitions, and driving business development efforts. Collaborate with diverse teams to translate complex...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$150K - $215K *

Innovate by driving real-time communications strategies and partner engagement. Shape impactful narratives during breaking news while building scalable programs that connect communications outcomes to...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$180K *

Drive the development of a cutting-edge platform, enhancing integrations and architecture for payroll and HR systems. Collaborate closely with a small team to ensure a successful launch and ongoing im...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Unlock potential by leading IT operations and identity management, transforming strategy into action. Drive technical excellence in Microsoft Entra ID, endpoint platforms, and SaaS integrations while...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $100K *

Innovate structural designs for light gauge and cold-formed steel systems, ensuring compliance with California codes. Collaborate across teams to enhance manufacturability and efficiency in modular an...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Elevate our software engineering capabilities by designing and building modern, cloud-native data pipelines. Collaborate with diverse teams to ensure seamless project delivery and advocate for best pr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$200K - $250K *

Lead the charge in embedding Domino into complex enterprise IT landscapes. Drive strategic deployments, design robust architectures, and enhance AI/ML integrations while collaborating with cross-funct...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Drive the design and optimization of Oracle CX data architecture, ensuring effective data conversion and integration. Collaborate with cross-functional teams to enhance customer experience through inn...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

$133K - $262K *

Unlock potential by developing AI-driven solutions that enhance business processes and integrate with enterprise systems. Collaborate with clients and teams to shape the future of finance and accounti...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Legal & Accounting

$148K - $313K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them in architecting AI-first solutions within the Life Sciences sector, while driving internal initiatives and enhanc...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $150K *

Champion innovative data solutions by architecting scalable cloud data pipelines and lakes. Leverage deep financial services expertise to drive technical product management and ensure seamless data in...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$130K - $145K *

Lead the development and enhancement of modern web applications using Java, Spring, and Angular. Collaborate with cross-functional teams in an Agile environment to deliver reliable solutions while men...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $160K *

Transform enterprise solutions as a Salesforce Solution Architect, leading teams to deliver innovative, scalable projects. Drive presales, guide architecture, and leverage cutting-edge AI capabilities...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $170K *

Lead strategic contracts management, overseeing development and negotiation of federal contracts. Collaborate cross-functionally to ensure compliance and risk management while driving organizational g...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by designing intuitive AI experiences for diverse construction teams, blending interaction and visual design. You'll create mobile-first solutions for Superintendents and DCOs, ensuri...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $170K *

Shape the future of enterprise infrastructure by leading design, implementation, and optimization of systems. Drive automation, enhance security, and mentor junior staff while collaborating on strateg...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$82K - $172K *

Empower mission success by establishing automated testing frameworks and executing comprehensive test plans. Collaborate with teams to enhance IT service delivery and ensure high-quality performance a...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$88K - $154K *

Advance your career by leading process engineering for semiconductor projects. Collaborate with cross-functional teams to optimize systems, ensuring compliance with industry standards while mentoring...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $121K *

Join us to drive sales growth by identifying new business opportunities and nurturing client relationships. Leverage your technical and business acumen to influence stakeholders and close deals while...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Help us drive growth by identifying and closing automation opportunities. Collaborate with technical teams to deliver tailored solutions, build lasting customer relationships, and exceed sales targets...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$128K - $160K *

Empower federal agencies by delivering tailored data governance solutions, ensuring compliance and driving measurable outcomes. Collaborate cross-functionally to enhance customer success and expand Co...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.