Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$115K - $130K *

Transform the contracting process by managing the lifecycle of agreements, ensuring efficient execution while balancing risk and compliance. Collaborate with cross-functional teams to support business...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$185K - $231K *

Join a team that's redefining digital experiences by architecting scalable, resilient systems. Collaborate across teams to enhance performance and reliability while leveraging AI tools to drive innova...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $200K *

Manage compliance and regulatory functions for a global SaaS provider, advising on laws impacting enterprise clients. Collaborate cross-functionally to ensure timely compliance and develop best practi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Elevate customer success by implementing privacy-first healthcare marketing solutions. As an Implementation Engineer, you'll guide clients through technical setups, ensuring optimal performance and co...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$157K - $192K *

Develop and enhance a cloud-native agent harness, ensuring secure, reliable, and efficient operations. Collaborate with a dynamic team to deliver features, fix bugs, and innovate using AI throughout t...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $195K *

Unlock your potential by building advanced entity matching solutions. Collaborate with a dedicated team to transform complex data into actionable insights, ensuring transparency and accuracy in every...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Transform patient access by optimizing Epic Cadence workflows. Collaborate with clinical teams to enhance scheduling efficiency and support system improvements, ensuring seamless operations and superi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Shape the future of security by engineering robust controls for endpoints and email. As a Staff Security Engineer, you'll enhance our security posture, mentor peers, and ensure compliance in a regulat...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$93K - $150K *

Support and optimize cloud-based contact center platforms, ensuring service availability and excellent customer experience. Collaborate with teams to troubleshoot complex issues and enhance operationa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $266K *

Elevate your career by joining a dynamic team focused on innovative reporting solutions. Collaborate with business users and technical experts to design impactful dashboards and dataflows, driving suc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $190K *

Transform security solutions across multiple domains, driving technical direction and collaboration to address high-risk items and enhance Meta's security posture company-wide. Lead cross-functional t...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$108K - $251K *

Empower customer success by leading the design and implementation of AI and CCaaS solutions. Collaborate with cross-functional teams to create scalable architectures that enhance customer experience a...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Consumer Technology

$110K - $130K *

Transform enterprise VoIP infrastructure by leading design, engineering, and compliance efforts. Manage complex incidents, mentor technicians, and drive modernization projects while ensuring optimal p...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$121K - $164K *

Champion a team of analysts to enhance enterprise infrastructure services, ensuring reliable support and operational excellence. Collaborate with cross-functional teams to align priorities and drive c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $158K *

Innovate solutions by leveraging your expertise in data automation and systems engineering to enhance operational efficiency and support enterprise financial management systems...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $135K *

Unlock excellence in PCB design and manufacturing by leading DFM initiatives, developing complex multilayer layouts, and shaping best practices across engineering teams to enhance product performance...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$279K - $349K *

Drive the strategy and execution of dedicated infrastructure engineering, leading a high-performing team to enhance enterprise SaaS offerings, ensure compliance, and deliver exceptional customer exper...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a dynamic team as a SOC Engineer, where you'll onboard customers into managed security services, configure Microsoft security tools, and ensure reliable telemetry across diverse environments, all...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Transform customer engagement by leading a team of Solutions Architects, driving technical strategy and operational excellence across the India region while ensuring alignment with cross-functional pa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$115K - $117K *

Join a team that's dedicated to enhancing privacy compliance and cybersecurity. Collaborate with stakeholders to assess risks, develop training, and ensure adherence to federal regulations while prote...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$75K - $126K *

Innovate with us to enhance network security platforms, ensuring robust protection and operational efficiency. As a key engineer, you'll tackle complex challenges, automate processes, and collaborate...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$104K - $259K *

Engage in cutting-edge adversary research to lead a team in identifying and analyzing sophisticated cyber threats. Drive strategic initiatives, enhance security outcomes, and communicate findings to d...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$135K - $160K *

Unlock the potential of NetBox Delivery by leading software design, enhancing production reliability, and mentoring engineers. Shape the technical direction and ensure seamless deployment on Cloud and...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$165K - $195K *

Engage in strategic solution development for Federal Government initiatives, translating client needs into innovative technical strategies. Collaborate with cross-functional teams to deliver compellin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $253K *

Champion automation excellence by leading a team to design and implement robust automation strategies, ensuring reliability and security across systems while driving innovation in cloud and applicatio...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.