Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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1
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$85K - $100K *

Empower your career by leading a dynamic team in delivering innovative IT solutions that enhance operational efficiency and support academic and healthcare missions through effective software developm...

South Carolina, USRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$140K - $195K *

Transform your career by leading high-performing incident response teams, managing complex client engagements, and mentoring the next generation of cybersecurity experts while protecting organizations...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$124K - $161K *

Shape the future of clinical supplier quality by leading global oversight and compliance initiatives. Collaborate with cross-functional teams to ensure supplier performance aligns with regulatory stan...

New Jersey, USRemote

Reposted today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock insights by analyzing operational data and developing reporting tools. Collaborate with stakeholders to enhance data quality and streamline processes, delivering polished executive presentation...

Texas, USRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$250K - $275K *

Champion the alignment of technology with business strategy. As a Senior Client Solutions Architect, you will lead solution architecture for complex opportunities, collaborating closely with stakehold...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$127K - $169K *

Lead the charge in risk analysis and control, providing technical expertise to enhance underwriting goals and improve account management through strategic evaluations and recommendations...

Indiana, USRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $160K *

Advance your career by joining a dynamic team focused on delivering innovative enterprise solutions. Engage with a variety of technologies while supporting mission-critical systems. Drive customer suc...

RemoteRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$150K - $220K *

Contribute to corporate security by designing, implementing, and maintaining robust security measures while collaborating with IT, engineering, and business teams to address and mitigate risks across...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$91K - $163K *

Advance your career by leading clinical documentation improvement initiatives, overseeing staff training, and collaborating with healthcare teams to enhance documentation accuracy and compliance in in...

Chandler, AZRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead strategic growth in cyber solutions for defense agencies, enhancing national security through innovative programs and strong partnerships. This role requires expertise in business development, pi...

Virginia, USRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$160K - $200K *

Accelerate growth by leading strategic business development efforts in defense cybersecurity. Engage with senior leaders, cultivate relationships, and manage a robust pipeline to address complex cyber...

Virginia, USRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$140K - $175K *

Transform the marketing landscape by leading strategic initiatives that drive brand authority, generate qualified leads, and accelerate revenue growth in the cybersecurity compliance sector for defens...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Support clinical studies by assisting with scientific conduct, data reconciliation, and protocol management. Engage with stakeholders to ensure compliance and operational excellence across multiple st...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive clinical innovation by supporting the operational delivery of pivotal studies, collaborating cross-functionally, and ensuring compliance with industry standards. Play a key role in the medical m...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's shaping the future of FinTech by developing robust applications. Collaborate with engineers and product managers to deliver high-quality software solutions while ensuring compliance...

California, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by designing and managing Azure infrastructure, ensuring seamless hybrid connectivity and robust disaster recovery. Collaborate across teams to enhance operations, automate processes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$86K - $166K *

Join a dynamic team focused on cybersecurity incident management, where you'll analyze and resolve security incidents, develop proactive strategies, and safeguard sensitive data against evolving cyber...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$244K - $366K *

Transform technology leadership by driving strategic initiatives, enhancing cybersecurity, and fostering innovation across a decentralized organization. Collaborate with stakeholders to align technolo...

Toronto, ONRemote

6 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Champion privacy solutions by engaging with clients, delivering tailored demos, and driving sales success. Leverage your expertise to influence product development and navigate the intersection of AI...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$95K - $140K *

Empower organizations by leading incident response efforts, utilizing advanced forensic techniques to combat sophisticated cyber threats. Collaborate with a dynamic team to deliver impactful solutions...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$95K - $140K *

Empower organizations by leading incident response efforts, utilizing advanced forensic techniques to combat sophisticated cyber threats. Collaborate with a dynamic team to deliver impactful security...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$119K - $179K *

Lead the charge in architecting FHIR-compliant data models to enhance clinical data integration and usability, supporting patient care and research initiatives across the organization...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Champion financial excellence by leading a dynamic team, ensuring compliance, and delivering strategic insights to clients. Drive operational efficiency and foster a collaborative environment while ma...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Legal & Accounting

$63K - $111K *

Manage subcontract administration to ensure compliance and performance across all phases of the Supply Chain process, from proposal development to contract closeout, while fostering strong relationshi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$385K - $400K *

Pioneer a high-performing Sales Team in your region, driving growth through effective methodologies and mentorship. Lead initiatives to exceed quotas while fostering key relationships and ensuring bes...

Seattle, WARemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.