Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$130K *

Shape the future of IT security by enhancing compliance and risk management. Collaborate with cross-functional teams to identify risks and implement effective solutions, ensuring the organization meet...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $200K *

Drive portfolio strategy and execution by transforming market needs into profitable offers. Collaborate across teams to ensure alignment and operational readiness, enhancing sales confidence and optim...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Drive strategic capture initiatives to expand federal market presence, managing the full lifecycle from opportunity qualification to proposal submission. Collaborate with leadership and teams to devel...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$107K - $173K *

Lead the charge in optimizing SAP FICO systems, collaborating with Finance teams to enhance financial processes, ensuring compliance, and driving impactful projects on the SAP S4 HANA platform for imp...

Pennsylvania, USRemote

Today

  •   8 - 10 years exp.  •   Business Services

$135K - $216K *

Drive successful IT program delivery and customer relationships while managing financial performance and team leadership. Engage with stakeholders to identify growth opportunities and ensure high-qual...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$130K - $160K *

Engineer robust security solutions to protect users and partners. Collaborate with a dynamic team to enhance security across infrastructure, applications, and compliance, while writing production code...

New York City, NYRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$230K - $273K *

Transform the mobile integration landscape by spearheading the deployment of secure, efficient systems that enable seamless operation of USPS and Government Agency applications across Android devices...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$200K *

Drive your career by leading technical architecture and AI tooling development in a dynamic company transitioning to multi-platform solutions. Collaborate with teams, mentor talent, and engage with en...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$119K - $136K *

Unlock your potential by leading workforce transformation solutions that align business priorities with technology ecosystems. Engage with executives to design impactful strategies and drive measurabl...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $100K *

Contribute to the development and integration of mission-critical systems, applying systems engineering principles to ensure high reliability and security. Collaborate across teams to support the enti...

Pittsfield, MARemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $120K *

Help us optimize system solutions by analyzing user needs, documenting requirements, and bridging the gap between IT and business. You will play a key role in driving system development and implementa...

Washington, DCRemote

4 weeks ago

  •   8 - 10 years exp.  •   Staffing

$150K - $180K *

Transform client relationships by engaging with C-suite executives to drive strategic account growth. Collaborate on tailored solutions and industry insights, ensuring alignment with client goals and...

Mississauga, ONRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$95K - $115K *

Champion innovative solutions as a Business Solutions Analyst, collaborating with healthcare organizations to drive strategic initiatives and operational excellence across diverse projects and deliver...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $160K *

Join a dynamic team to build and enhance security practices, ensuring robust protection of sensitive data. Collaborate across engineering to create secure frameworks, manage identities, and fortify cl...

San Francisco, CARemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform customer success by leading strategic post-sales initiatives, fostering C-level partnerships, and driving business transformation. Ensure predictable renewals and maximize value through coll...

Addison, TXRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Lead the CDI Department by acting as a clinical and technical resource, facilitating communication between customers and leadership, and ensuring operational standards are met through effective workfl...

New Orleans, LARemote

Today

  •   Less than 5 years exp.  •   Healthcare

$111K - $206K *

Drive effective contract management by collaborating across functions to ensure compliance, negotiate terms, and support business objectives. Lead audits and training while maintaining strong relation...

Three Mile Bay, NYRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$89K - $165K *

Empower your career by managing contracts from proposal to administration. Collaborate across functions to ensure compliance and build strong customer relationships while leading audits and training i...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$85K - $95K *

Elevate K-12 assessment programs by leading content development, ensuring quality and operational excellence. Collaborate cross-functionally, manage client relationships, and leverage AI tools to enha...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Lead the charge in enhancing partner experiences through strategic digital initiatives. Drive the evolution of a comprehensive partner portal, ensuring seamless engagement and measurable outcomes whil...

Overland Park, KSRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Empower top-tier enterprise customers by architecting secure development practices and guiding complex DevSecOps transformations. Serve as a trusted advisor to drive adoption, retention, and measurabl...

Boston, MARemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$116K - $210K *

Transform environmental remediation projects as a technical leader, guiding multidisciplinary teams through complex regulatory challenges, and fostering collaboration with stakeholders to ensure compl...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Elevate clinical research by assisting with study design, medical monitoring, and compliance to ensure effective execution of clinical trials and contribute positively to patient outcomes in alignment...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower healthcare interoperability by providing technical support and troubleshooting for integration services. Collaborate with cross-functional teams to resolve issues effectively and enhance syste...

Dallas, TXRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Engage with clients to transform complex Enterprise Architecture needs into actionable solutions. Manage implementation workstreams, ensuring effective onboarding and training while fostering strong r...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.