Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$87K - $119K *

Transform the landscape of fraud detection by leading a skilled SIU team. Oversee investigations, collaborate with law enforcement, and ensure compliance while mentoring staff to uphold integrity in h...

Newark, NJRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Shape the future of customer success by providing technical guidance and innovative solutions. Act as a trusted advisor, ensuring clients maximize product value while managing complex issues and advoc...

Austin, TXRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the design and implementation of robust security measures to protect sensitive health information, ensuring compliance with HIPAA and other regulations while collaborating with cross-functional t...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in managing IT infrastructure and systems while mentoring a dedicated team. Drive cybersecurity initiatives, oversee technology planning, and ensure seamless end-user support to enhanc...

Ohio, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$160K - $195K *

Create impactful client relationships and drive growth strategies across enterprise accounts. Lead cross-functional teams to deliver exceptional outcomes while aligning solutions with client objective...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $148K *

Unlock potential by managing CA Datacom environments, optimizing databases, and ensuring 24x7 support. Collaborate with vendors, implement best practices, and maintain documentation to enhance client...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $195K *

Shape the future of global security by leading incident response engagements, utilizing advanced forensic techniques, and mentoring teams to protect organizations from sophisticated cyber threats...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$140K - $195K *

Partner with us to lead incident response engagements and protect organizations from advanced threats. Utilize your expertise in forensics and network analysis to drive impactful security solutions an...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$140K - $195K *

Drive impactful incident response initiatives, leading teams to protect organizations from advanced threats. Engage in cutting-edge investigations and develop innovative strategies to enhance global s...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Grow your career with a dynamic team leading threat intelligence and detection engineering. Shape strategies to protect diverse industries from cyber threats, while building a high-impact program that...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $135K *

Join a team that's dedicated to enhancing application services and driving strategic initiatives. Lead a diverse team to improve tax processing and business outcomes while fostering collaboration acro...

Madison, WIRemote

Today

  •   5 - 7 years exp.  •   Business Services

$75K - $100K *

Drive your career forward in a 12-week fellowship, gaining hands-on IT experience, enhancing problem-solving skills, and collaborating on diverse projects within a dynamic team environment...

Coral Gables, FLRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$59K - $106K *

Empower the future of air traffic control by supporting the FAA's Radar Surveillance Replacement initiative. Play a key role in installation and consultation at critical airports, ensuring high-qualit...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$59K - $106K *

Unlock your potential by supporting diverse EOSH programs for the FAA. Collaborate with a dedicated team, conduct inspections, and provide training while ensuring compliance with safety regulations. E...

Boston, MARemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $140K *

Engage in leading complex, cross-functional programs for healthcare clients. Drive strategic initiatives, manage risks, and enhance stakeholder communication while delivering impactful results in a dy...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $153K *

Lead the enhancement and administration of enterprise endpoint security technologies, collaborating with cross-functional teams to optimize security processes and improve detection capabilities in a g...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $140K *

Empower the future of naval supply systems by analyzing, refining, and supporting application engineering and integration. Collaborate with mission partners to enhance system functionality and ensure...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$120K - $150K *

Unlock a seamless end-user experience by overseeing technical support, mentoring, and cross-functional collaboration in a dynamic IT environment dedicated to operational excellence and service improve...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $115K *

Transform federal human capital management by leveraging your HR expertise. Collaborate with a high-performing team to enhance service delivery and drive continuous improvement in HR processes and sys...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$63K - $105K *

Champion the development of AI agents and workflows, leveraging GenAI.mil to create innovative automated solutions. Collaborate with cross-functional teams to enhance processes and deliver high-qualit...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Champion operational excellence by spearheading IT Business Systems processes, ensuring effective training, governance, and budgeting. Analyze user support data to enhance service delivery across dive...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$204K - $220K *

Lead the charge in building a world-class sales enablement function, driving onboarding, training, and content strategy to enhance seller effectiveness and accelerate new hire productivity across a gl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Tackle emerging cybersecurity threats and enhance security measures through advanced threat analysis, vulnerability assessment, and incident response solutions while collaborating with technical teams...

Chattanooga, TNRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$230K - $310K *

Shape the future of IT Infrastructure & Operations by leading strategy and delivery for rapid growth and innovation in a tech-driven environment, ensuring security, scalability, and support across mul...

RemoteRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Transportation

$110K - $130K *

Lead the charge in optimizing ServiceNow solutions, leveraging 5+ years of expertise to enhance ITSM processes and drive efficiency in federal environments. Collaborate with cross-functional teams to...

Houston, TXRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.