Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$110K - $130K *

Elevate your career by leading strategic IT solutions and driving software asset management excellence. Collaborate with stakeholders, mentor peers, and influence outcomes through innovative analysis...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$117K - $161K *

Drive enterprise Identity Security solutions in a complex healthcare environment, focusing on secure identity lifecycle management, authentication, and compliance while integrating clinical applicatio...

Kentucky, USRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $148K *

Drive advanced technical support for trading solutions, managing complex incidents, troubleshooting, and collaborating with teams to enhance system performance and ensure exceptional customer experien...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$116K - $192K *

Champion the successful implementation of AI-driven solutions, ensuring timely delivery and stakeholder alignment. Collaborate with customers and partners to drive business value through innovative wo...

Albany, NYRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$132K - $237K *

Join a dynamic team to architect and implement global security compliance frameworks, driving enterprise-wide initiatives and ensuring adherence to regulatory standards across complex cloud environmen...

Cambridge, MARemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$66K - $106K *

Contribute to the modernization of America's airspace by executing software installations and updates for the FAA's Terminal Flight Data Manager program, ensuring operational readiness and compliance...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $110K *

Unlock potential by creating clear, accessible documentation for federal programs. Collaborate with experts to transform complex regulations into user-friendly materials, ensuring compliance and accur...

Virginia, USRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$116K - $192K *

Engage your expertise to lead the successful implementation of innovative AI solutions, ensuring timely delivery and stakeholder satisfaction while managing project resources and fostering collaborati...

San Diego, CARemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$129K - $185K *

Unlock potential by leading the Customer Identity & Access Management function, overseeing CIAM platform operations, and driving identity strategy across global digital ecosystems while collaborating...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $132K *

Join a team that's dedicated to enhancing cybersecurity measures across cloud environments. Lead initiatives in data protection, compliance, and security awareness while mentoring peers and implementi...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$107K - $204K *

Take ownership of complex contract management, ensuring compliance and strategic alignment while advising on contractual matters and mitigating risks. Collaborate with cross-functional teams to drive...

Connecticut, USRemote

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$107K - $204K *

Join a dynamic team as you manage complex government contracts, ensuring compliance and fostering strong relationships. Utilize your negotiation skills to support the P&C Mil Spares EPS aftermarket bu...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$160K - $190K *

Transform security solutions across multiple domains, driving technical direction and collaboration to address high-risk items and enhance Meta's security posture company-wide. Lead cross-functional t...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Drive the evolution of a cutting-edge CI/CD platform, integrating AI tools and leading a team of DevOps engineers. Own production releases and implement modern delivery practices to enhance software d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$180K - $230K *

Lead the charge in designing and delivering innovative Azure data solutions, ensuring technical excellence and client satisfaction while guiding teams through complex implementations and strategic eng...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$93K - $179K *

Contribute to innovative software solutions by designing, developing, and testing applications. Engage in all phases of the software lifecycle while mentoring junior engineers and enhancing operationa...

San Antonio, TXRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $285K *

Transform complex spacecraft systems through leadership in integration, architecture, and verification, ensuring mission success. Collaborate across disciplines to define strategic requirements and fo...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$112K - $179K *

Lead architecture and delivery for a major SaaS/PaaS platform, driving technical vision and agile development. Collaborate with stakeholders to ensure compliance and optimize solutions, while mentorin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Drive the design and enhancement of corporate security infrastructure, improving automation and maintaining strong security posture in a cloud environment. Collaborate with teams to implement controls...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$156K - $258K *

Elevate your career by managing executive relationships and driving strategic initiatives for top-tier clients. Lead virtual teams to deliver tailored ServiceNow solutions, ensuring exceptional custom...

San Diego, CARemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$173K - $259K *

Transform the customer onboarding experience by bridging Product Management and Engineering. Lead initiatives that prioritize seamless integration, scalability, and customer success while ensuring opt...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Unlock new business opportunities within U.S. Federal Government agencies by driving strategic sales initiatives, building executive relationships, and navigating complex procurement processes to enha...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Transform billing operations by leading a team to optimize healthcare revenue cycle processes, ensuring timely and accurate claims submission while driving performance improvements and fostering stron...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Shape the future of enterprise architecture by leading strategic initiatives, translating business goals into scalable solutions, and guiding cross-functional teams in integrating complex healthcare a...

Texas, USRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$385K - $400K *

Lead the charge in driving sales success by mentoring a dynamic team, implementing best practices, and fostering client relationships to exceed quotas in a fast-paced environment...

New York, NYRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.