Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$272K - $374K *

Empower our sales team to drive revenue growth by leading strategic engagements with Federal Systems Integrators. Utilize your expertise to craft account plans, build relationships, and navigate compl...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$77K - $101K *

Join a team that's dedicated to optimizing licensing and renewals. Leverage your expertise in VMware/Broadcom to enhance customer retention and drive sales growth through effective account management...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Develop and implement safety policies while ensuring compliance with health and safety regulations across construction projects. Collaborate with multidisciplinary teams to enhance safety measures and...

Dallas, TXRemote

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Unlock potential by leading technology strategy for Facilities Management and Workplace Services. Drive platform governance, lifecycle management, and continuous improvement to enhance operations and...

Indianapolis, INRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $97K *

Join us to enhance healthcare technology by delivering high-quality automated testing solutions. Collaborate with cross-functional teams to ensure secure, compliant applications and APIs in a dynamic...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a team that's dedicated to enhancing technical enablement for sales and engineering roles. You'll develop scalable training programs, manage onboarding, and create hands-on resources to ensure fl...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$135K - $205K *

Lead the charge in delivering client-focused mainframe solutions. Oversee diverse projects, manage teams, and leverage strategic insights to enhance hardware and software lifecycle management while fo...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$95K - $117K *

Drive impactful digital health solutions across multiple countries, enhancing health systems and capacity building. Collaborate with diverse teams to implement strategies that ensure sustainable healt...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$54K - $119K *

Support accreditation readiness by coordinating committees, managing evidence, and tracking performance metrics. Collaborate with cross-functional teams to ensure compliance and enhance quality initia...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $134K *

Shape the future of customer success by leading the deployment of IoT solutions for enterprise clients. Your role will bridge sales and strategy, ensuring clients maximize the value of their technolog...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate project outcomes by leading cross-functional teams to deliver clinical research projects on time and within budget, ensuring compliance with regulatory standards and client expectations while...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$155K - $210K *

Lead complex programs and strategic client engagements, driving technology transformation and sustainable business value. Act as a trusted adviser to C-level stakeholders, shaping program vision and e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Transform the future of supply chain data governance and AI integration. Lead the design and standardization of data models and AI agents, ensuring compliance and interoperability across systems while...

Sandy, UTRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$70K - $126K *

Join our team to identify, assess, and report on enterprise risks while supporting sustainability initiatives. Collaborate across business units to enhance corporate ESG strategies and improve risk ma...

Missouri, USRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Explore the opportunity to tackle complex operational and product challenges with enterprise customers. Collaborate across teams to drive solutions, enhance workflows, and ensure successful implementa...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $173K *

Lead the charge in developing and implementing advanced risk segmentation strategies, leveraging statistical methodologies and machine learning to optimize financial returns and enhance model performa...

Southfield, MIRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$108K - $180K *

Execute complex, cross-functional projects that align with strategic objectives. Collaborate with stakeholders and teams to ensure timely delivery, budget adherence, and successful outcomes while driv...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$120K - $145K *

Transform remote sensing capabilities by architecting advanced exploitation pipelines, leading multi-disciplinary teams, and developing innovative tools that enhance space observation analytics and mi...

Fairborn, OHRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $160K *

Lead the architecture of certificate lifecycle management capabilities that enhance security across complex environments, collaborating with product and engineering teams to build scalable systems tha...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$149K - $201K *

Join a team that's transforming data into impactful AI solutions. As an AI Engineer/Architect, you'll lead innovative projects, collaborate with stakeholders, and drive automation in mission-critical...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $150K *

Shape the future of B2B content marketing by leading strategy, production, and executive voice. Drive impactful narratives that generate pipeline and engage security practitioners through innovative...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$161K - $299K *

Engineer solutions by applying functional knowledge to design and customize SAP or PeopleSoft applications, ensuring alignment with business needs. Collaborate with teams to write requirements, develo...

Fort Worth, TXRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $95K *

Drive innovative system designs for security, video, access, and fire alarm solutions. Collaborate with teams to deliver tailored solutions, support junior members, and ensure project success through...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$95K - $115K *

Join a team that's enhancing enterprise interoperability by designing, building, and supporting integration solutions in healthcare environments. Collaborate with clients to optimize technology usage...

New Haven, CTRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$122K - $227K *

Develop and secure AI/ML evaluation infrastructure, ensuring robust testing and validation of systems. Collaborate with cross-functional teams to enhance security practices and methodologies, driving...

New Jersey, USRemote

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.